TY  - JOUR
AU  - Dobričić, Vladimir
AU  - Francuski, Bojana M.
AU  - Jaćević, Vesna
AU  - Rodić, Marko V.
AU  - Vladimirov, Sote
AU  - Čudina, Olivera
AU  - Francuski, Đorđe D.
PY  - 2015
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/866
AB  - The L-phenylalanine methyl ester derivative of dexamethasone-derived cortienic acid (DF) was synthesized and its crystal structure characterized by the X-ray diffraction method. The crystal system is orthorhombic with space group P2(1)2(1)2(1) and cell constants a = 8.2969(3) angstrom, b = 18.9358(8) angstrom, c = 20.0904(6) angstrom, V = 3156.4(2) angstrom(3) and Z = 4. Ring A of the steroid nucleus and phenyl ring in the 17 beta-side chain are almost planar. Rings B and C have a slightly distorted chair conformation, whereas ring D has an envelope conformation. The packing of DF is characterized by a network of intermolecular hydrogen bonds involving the O4 atom from one side of the steroid nucleus and O1 and F1 atoms from the other side as hydrogen bond acceptors. Apart from the intermolecular hydrogen bonds in the crystal packing, there are also numerous intramolecular hydrogen bonds of the N-H center dot center dot center dot O, C-H center dot center dot center dot O and C-H center dot center dot center dot F type. The local anti-inflammatory activity of DF was evaluated using the croton oil-induced ear oedema test. This derivative achieved maximal inhibition of ear oedema at significantly lower concentration in comparison with dexamethasone.
T2  - Journal of the Serbian Chemical Society
T1  - Synthesis, crystal structure and local anti-inflammatory activity of the L-phenylalanine methyl ester derivative of dexamethasone-derived cortienic acid
VL  - 80
IS  - 12
SP  - 1481
EP  - 1488
DO  - 10.2298/JSC150505067D
ER  - 

@article{
author = "Dobričić, Vladimir and Francuski, Bojana M. and Jaćević, Vesna and Rodić, Marko V. and Vladimirov, Sote and Čudina, Olivera and Francuski, Đorđe D.",
year = "2015",
abstract = "The L-phenylalanine methyl ester derivative of dexamethasone-derived cortienic acid (DF) was synthesized and its crystal structure characterized by the X-ray diffraction method. The crystal system is orthorhombic with space group P2(1)2(1)2(1) and cell constants a = 8.2969(3) angstrom, b = 18.9358(8) angstrom, c = 20.0904(6) angstrom, V = 3156.4(2) angstrom(3) and Z = 4. Ring A of the steroid nucleus and phenyl ring in the 17 beta-side chain are almost planar. Rings B and C have a slightly distorted chair conformation, whereas ring D has an envelope conformation. The packing of DF is characterized by a network of intermolecular hydrogen bonds involving the O4 atom from one side of the steroid nucleus and O1 and F1 atoms from the other side as hydrogen bond acceptors. Apart from the intermolecular hydrogen bonds in the crystal packing, there are also numerous intramolecular hydrogen bonds of the N-H center dot center dot center dot O, C-H center dot center dot center dot O and C-H center dot center dot center dot F type. The local anti-inflammatory activity of DF was evaluated using the croton oil-induced ear oedema test. This derivative achieved maximal inhibition of ear oedema at significantly lower concentration in comparison with dexamethasone.",
journal = "Journal of the Serbian Chemical Society",
title = "Synthesis, crystal structure and local anti-inflammatory activity of the L-phenylalanine methyl ester derivative of dexamethasone-derived cortienic acid",
volume = "80",
number = "12",
pages = "1481-1488",
doi = "10.2298/JSC150505067D"
}

Dobričić, V., Francuski, B. M., Jaćević, V., Rodić, M. V., Vladimirov, S., Čudina, O.,& Francuski, Đ. D.. (2015). Synthesis, crystal structure and local anti-inflammatory activity of the L-phenylalanine methyl ester derivative of dexamethasone-derived cortienic acid. in Journal of the Serbian Chemical Society, 80(12), 1481-1488.
https://doi.org/10.2298/JSC150505067D

Dobričić V, Francuski BM, Jaćević V, Rodić MV, Vladimirov S, Čudina O, Francuski ĐD. Synthesis, crystal structure and local anti-inflammatory activity of the L-phenylalanine methyl ester derivative of dexamethasone-derived cortienic acid. in Journal of the Serbian Chemical Society. 2015;80(12):1481-1488.
doi:10.2298/JSC150505067D .

Dobričić, Vladimir, Francuski, Bojana M., Jaćević, Vesna, Rodić, Marko V., Vladimirov, Sote, Čudina, Olivera, Francuski, Đorđe D., "Synthesis, crystal structure and local anti-inflammatory activity of the L-phenylalanine methyl ester derivative of dexamethasone-derived cortienic acid" in Journal of the Serbian Chemical Society, 80, no. 12 (2015):1481-1488,
https://doi.org/10.2298/JSC150505067D . .

TY  - JOUR
AU  - Brborić, Jasmina
AU  - Jovanovic, M. S.
AU  - Vranješ-Đurić, Sanja
AU  - Čudina, Olivera
AU  - Marković, Bojan D.
AU  - Vladimirov, Sote
PY  - 2013
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/5394
AB  - The partition coefficients (log P) of theoretically possible alkyliodinated iminodiacetic acid (IDA) derivatives and commercial IDA derivatives were calculated using two computer programs: ChemSketch Log P and ChemOffice Ultra. Newly synthesized ligands (DIETHYLIODIDA and DIISOPROPYLIODIDA) with the highest calculated log P were labeled with technetium-99m. The biodistribution and the influence of bilirubin on their biokinetics were investigated in rats and compared to corresponding results for commercial Tc-99m-BROMIDA. Log P of Tc-99m-complexes of synthesized ligands were determined experimentally as well as the protein binding. In comparison to Tc-99m-BROMIDA, Tc-99m-DIETHYLIODIDA has: (a) better biliary excretion (2.76 +/- 0.15%ID/g versus 1.83 +/- 0.10%ID/g); (b) faster hepatic clearance (2.90 +/- 0.21%ID/g versus 7.47 +/- 0.70%ID/g) and decreased biliary excretion (for 14% versus 22%) in conditions of hyperbilirubinemia after 15 min. It is proved that Tc-99m-DIISOPROPYLIODIDA has a prolonged hepatic transit time and decreased biliary excretion. (c) 2012 Elsevier Ltd. All rights reserved.
T2  - Applied Radiation and Isotopes
T1  - The effect of lipophilicity on the hepatobiliary properties of iminodiacetic acid derivatives in the conditions of hyperbilirubinemia
VL  - 74
SP  - 31
EP  - 35
DO  - 10.1016/j.apradiso.2012.12.014
ER  - 

@article{
author = "Brborić, Jasmina and Jovanovic, M. S. and Vranješ-Đurić, Sanja and Čudina, Olivera and Marković, Bojan D. and Vladimirov, Sote",
year = "2013",
abstract = "The partition coefficients (log P) of theoretically possible alkyliodinated iminodiacetic acid (IDA) derivatives and commercial IDA derivatives were calculated using two computer programs: ChemSketch Log P and ChemOffice Ultra. Newly synthesized ligands (DIETHYLIODIDA and DIISOPROPYLIODIDA) with the highest calculated log P were labeled with technetium-99m. The biodistribution and the influence of bilirubin on their biokinetics were investigated in rats and compared to corresponding results for commercial Tc-99m-BROMIDA. Log P of Tc-99m-complexes of synthesized ligands were determined experimentally as well as the protein binding. In comparison to Tc-99m-BROMIDA, Tc-99m-DIETHYLIODIDA has: (a) better biliary excretion (2.76 +/- 0.15%ID/g versus 1.83 +/- 0.10%ID/g); (b) faster hepatic clearance (2.90 +/- 0.21%ID/g versus 7.47 +/- 0.70%ID/g) and decreased biliary excretion (for 14% versus 22%) in conditions of hyperbilirubinemia after 15 min. It is proved that Tc-99m-DIISOPROPYLIODIDA has a prolonged hepatic transit time and decreased biliary excretion. (c) 2012 Elsevier Ltd. All rights reserved.",
journal = "Applied Radiation and Isotopes",
title = "The effect of lipophilicity on the hepatobiliary properties of iminodiacetic acid derivatives in the conditions of hyperbilirubinemia",
volume = "74",
pages = "31-35",
doi = "10.1016/j.apradiso.2012.12.014"
}

Brborić, J., Jovanovic, M. S., Vranješ-Đurić, S., Čudina, O., Marković, B. D.,& Vladimirov, S.. (2013). The effect of lipophilicity on the hepatobiliary properties of iminodiacetic acid derivatives in the conditions of hyperbilirubinemia. in Applied Radiation and Isotopes, 74, 31-35.
https://doi.org/10.1016/j.apradiso.2012.12.014

Brborić J, Jovanovic MS, Vranješ-Đurić S, Čudina O, Marković BD, Vladimirov S. The effect of lipophilicity on the hepatobiliary properties of iminodiacetic acid derivatives in the conditions of hyperbilirubinemia. in Applied Radiation and Isotopes. 2013;74:31-35.
doi:10.1016/j.apradiso.2012.12.014 .

Brborić, Jasmina, Jovanovic, M. S., Vranješ-Đurić, Sanja, Čudina, Olivera, Marković, Bojan D., Vladimirov, Sote, "The effect of lipophilicity on the hepatobiliary properties of iminodiacetic acid derivatives in the conditions of hyperbilirubinemia" in Applied Radiation and Isotopes, 74 (2013):31-35,
https://doi.org/10.1016/j.apradiso.2012.12.014 . .

TY  - CONF
AU  - Čudina, Olivera
AU  - Janković, Ivana A.
AU  - Brborić, Jasmina
AU  - Karljiković-Rajić, Katarina
AU  - Vladimirov, Sote
PY  - 2008
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9370
AB  - The interaction of valsartan (VAL), an angiotensin II receptor antagonist, with cationic surfactant cetyltrimethylammonium bromide (CTAB) was investigated. To quantify the degree of VAL/CTAB interactions, two constants were calculated by using mathematical models: micelle/water partition coefficient and drug/micelle binding constant.
PB  - Society of Physical Chemists of Serbia
C3  - Physical chemistry 2008 : 9th international conference on fundamental and applied aspects of physical chemistry
T1  - Study of valsartan interaction with micelles as a model system for biomembrane
VL  - 1
SP  - 366
EP  - 368
UR  - https://hdl.handle.net/21.15107/rcub_vinar_9370
ER  - 

@conference{
author = "Čudina, Olivera and Janković, Ivana A. and Brborić, Jasmina and Karljiković-Rajić, Katarina and Vladimirov, Sote",
year = "2008",
abstract = "The interaction of valsartan (VAL), an angiotensin II receptor antagonist, with cationic surfactant cetyltrimethylammonium bromide (CTAB) was investigated. To quantify the degree of VAL/CTAB interactions, two constants were calculated by using mathematical models: micelle/water partition coefficient and drug/micelle binding constant.",
publisher = "Society of Physical Chemists of Serbia",
journal = "Physical chemistry 2008 : 9th international conference on fundamental and applied aspects of physical chemistry",
title = "Study of valsartan interaction with micelles as a model system for biomembrane",
volume = "1",
pages = "366-368",
url = "https://hdl.handle.net/21.15107/rcub_vinar_9370"
}

Čudina, O., Janković, I. A., Brborić, J., Karljiković-Rajić, K.,& Vladimirov, S.. (2008). Study of valsartan interaction with micelles as a model system for biomembrane. in Physical chemistry 2008 : 9th international conference on fundamental and applied aspects of physical chemistry
Society of Physical Chemists of Serbia., 1, 366-368.
https://hdl.handle.net/21.15107/rcub_vinar_9370

Čudina O, Janković IA, Brborić J, Karljiković-Rajić K, Vladimirov S. Study of valsartan interaction with micelles as a model system for biomembrane. in Physical chemistry 2008 : 9th international conference on fundamental and applied aspects of physical chemistry. 2008;1:366-368.
https://hdl.handle.net/21.15107/rcub_vinar_9370 .

Čudina, Olivera, Janković, Ivana A., Brborić, Jasmina, Karljiković-Rajić, Katarina, Vladimirov, Sote, "Study of valsartan interaction with micelles as a model system for biomembrane" in Physical chemistry 2008 : 9th international conference on fundamental and applied aspects of physical chemistry, 1 (2008):366-368,
https://hdl.handle.net/21.15107/rcub_vinar_9370 .

TY  - JOUR
AU  - Čudina, Olivera
AU  - Brborić, Jasmina
AU  - Janković, Ivana A.
AU  - Karljiković-Rajić, Katarina.
AU  - Vladimirova, S.
PY  - 2008
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/3494
AB  - In this study, the interaction of valsartan (VAL), an angiotensin II receptor antagonist, with cationic surfactant cetyltrimethylammonium bromide (CTAB) was investigated. The effect of cationic micelles on spectroscopic and acid-base properties of VAL was carried out using UV spectrophotometry at physiological conditions (pH 7.4). The binding of VAL to CTAB micelles implied a shift in drug acidity constant (pK(a)(water) - pK(a)(micelle) = 1.69) proving the great affinity of VAL dianion for the positively charged CTAB micelle surface. To quantify the degree of VAL/CTAB interaction, two constants were calculated by using mathematical models: micelle/water partition coefficient (K-x) and drug/micelle binding constant (K-b). The decrease of K-x with VAL concentration, obtained by using pseudo-phase model, is consistent with an adsorption-like phenomenon. From the dependence of differential absorbance at lambda = 295 nm on CTAB concentration, by using mathematical model that treats the solubilization of VAL dianion as its binding to specific sites in the micelles (Langmuir adsorption isotherm), the binding constant (K-b = (2.50 +/- 10.49) x 10(4) M-1) was obtained. Binding constant VAL/CTAB was also calculated using micellar liquid chromatography (MLC). (C) 2008 Elsevier B.V. All rights reserved.
T2  - Colloids and Surfaces. B: Biointerfaces
T1  - Study of valsartan interaction with micelles as a model system for biomembranes
VL  - 65
IS  - 1
SP  - 80
EP  - 84
DO  - 10.1016/j.colsurfb.2008.03.002
ER  - 

@article{
author = "Čudina, Olivera and Brborić, Jasmina and Janković, Ivana A. and Karljiković-Rajić, Katarina. and Vladimirova, S.",
year = "2008",
abstract = "In this study, the interaction of valsartan (VAL), an angiotensin II receptor antagonist, with cationic surfactant cetyltrimethylammonium bromide (CTAB) was investigated. The effect of cationic micelles on spectroscopic and acid-base properties of VAL was carried out using UV spectrophotometry at physiological conditions (pH 7.4). The binding of VAL to CTAB micelles implied a shift in drug acidity constant (pK(a)(water) - pK(a)(micelle) = 1.69) proving the great affinity of VAL dianion for the positively charged CTAB micelle surface. To quantify the degree of VAL/CTAB interaction, two constants were calculated by using mathematical models: micelle/water partition coefficient (K-x) and drug/micelle binding constant (K-b). The decrease of K-x with VAL concentration, obtained by using pseudo-phase model, is consistent with an adsorption-like phenomenon. From the dependence of differential absorbance at lambda = 295 nm on CTAB concentration, by using mathematical model that treats the solubilization of VAL dianion as its binding to specific sites in the micelles (Langmuir adsorption isotherm), the binding constant (K-b = (2.50 +/- 10.49) x 10(4) M-1) was obtained. Binding constant VAL/CTAB was also calculated using micellar liquid chromatography (MLC). (C) 2008 Elsevier B.V. All rights reserved.",
journal = "Colloids and Surfaces. B: Biointerfaces",
title = "Study of valsartan interaction with micelles as a model system for biomembranes",
volume = "65",
number = "1",
pages = "80-84",
doi = "10.1016/j.colsurfb.2008.03.002"
}

Čudina, O., Brborić, J., Janković, I. A., Karljiković-Rajić, Katarina.,& Vladimirova, S.. (2008). Study of valsartan interaction with micelles as a model system for biomembranes. in Colloids and Surfaces. B: Biointerfaces, 65(1), 80-84.
https://doi.org/10.1016/j.colsurfb.2008.03.002

Čudina O, Brborić J, Janković IA, Karljiković-Rajić K, Vladimirova S. Study of valsartan interaction with micelles as a model system for biomembranes. in Colloids and Surfaces. B: Biointerfaces. 2008;65(1):80-84.
doi:10.1016/j.colsurfb.2008.03.002 .

Čudina, Olivera, Brborić, Jasmina, Janković, Ivana A., Karljiković-Rajić, Katarina., Vladimirova, S., "Study of valsartan interaction with micelles as a model system for biomembranes" in Colloids and Surfaces. B: Biointerfaces, 65, no. 1 (2008):80-84,
https://doi.org/10.1016/j.colsurfb.2008.03.002 . .

TY  - CONF
AU  - Čudina, Olivera
AU  - Vladimirov, S.
AU  - Čomor, Mirjana
AU  - Janković, Ivana A.
PY  - 2006
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9423
AB  - The interaction of the anion of quinapril (QUIN), angiotensin converting enzyme (ACE) inhibitor, with cationic surfactant cetyltrimethylammonium bromide (CTAB) was studied as a model system for drug/membrane interactions. From the dependence of differential absorbance at λ=272 nm on CTAB concentration, by using mathematical model that treats the solubilization of QUIN anion as its binding to specific sites in the micelles (Langmuir adsorption isotherm), the binding constant Kb was obtained.
PB  - Society of Physical Chemists of Serbia
C3  - Physical chemistry 2006: 8th international conference on fundemental and applied aspract of physical chemistry
T1  - Partitioning of quinapril anion between cetyltrimethylammonium bromide micelles and water
SP  - 353
EP  - 355
UR  - https://hdl.handle.net/21.15107/rcub_vinar_9423
ER  - 

@conference{
author = "Čudina, Olivera and Vladimirov, S. and Čomor, Mirjana and Janković, Ivana A.",
year = "2006",
abstract = "The interaction of the anion of quinapril (QUIN), angiotensin converting enzyme (ACE) inhibitor, with cationic surfactant cetyltrimethylammonium bromide (CTAB) was studied as a model system for drug/membrane interactions. From the dependence of differential absorbance at λ=272 nm on CTAB concentration, by using mathematical model that treats the solubilization of QUIN anion as its binding to specific sites in the micelles (Langmuir adsorption isotherm), the binding constant Kb was obtained.",
publisher = "Society of Physical Chemists of Serbia",
journal = "Physical chemistry 2006: 8th international conference on fundemental and applied aspract of physical chemistry",
title = "Partitioning of quinapril anion between cetyltrimethylammonium bromide micelles and water",
pages = "353-355",
url = "https://hdl.handle.net/21.15107/rcub_vinar_9423"
}

Čudina, O., Vladimirov, S., Čomor, M.,& Janković, I. A.. (2006). Partitioning of quinapril anion between cetyltrimethylammonium bromide micelles and water. in Physical chemistry 2006: 8th international conference on fundemental and applied aspract of physical chemistry
Society of Physical Chemists of Serbia., 353-355.
https://hdl.handle.net/21.15107/rcub_vinar_9423

Čudina O, Vladimirov S, Čomor M, Janković IA. Partitioning of quinapril anion between cetyltrimethylammonium bromide micelles and water. in Physical chemistry 2006: 8th international conference on fundemental and applied aspract of physical chemistry. 2006;:353-355.
https://hdl.handle.net/21.15107/rcub_vinar_9423 .

Čudina, Olivera, Vladimirov, S., Čomor, Mirjana, Janković, Ivana A., "Partitioning of quinapril anion between cetyltrimethylammonium bromide micelles and water" in Physical chemistry 2006: 8th international conference on fundemental and applied aspract of physical chemistry (2006):353-355,
https://hdl.handle.net/21.15107/rcub_vinar_9423 .

TY  - JOUR
AU  - Čudina Olivera
AU  - Janković, Ivana A.
AU  - Čomor, Mirjana
AU  - Vladimirov, Sote
PY  - 2006
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/3070
AB  - In this study, the interaction of the anion of quinapril (QUIN), angiotensin converting enzyme (ACE) inhibitor, with cationic surfactant cetyltrimethylammonium bromide (CTAB) was investigated. The effect of cationic micelles on the spectroscopic and acid-base properties of QUIN was studied at pH 8. The binding of QUIN anion to CTAB micelles implied a shift in drug acidity constant (pK(a)(water) - pK(a)(micelle) = 1.39) proving the great affinity of negatively charged QUIN ion for the positively charged CTAB micelle surface. The strong dependence of the partition coefficient K-x on QUIN concentration, obtained by using pseudo-phase model, is consistent with an adsorption-like phenomenon. From the dependence of differential absorbance at lambda = 272 nm on CTAB concentration, by using mathematical model that treats the solubilization of QUIN anion as its binding to specific sites in the micelles (Langmuir adsorption isotherm), the binding constant K-b = (2.3 +/- 0.4) x 10(3) mol(-1) dm(3) was obtained. QUIN-CTAB binding constant was also calculated from micellar liquid chromatography (MLC) and this method was found to be not accurate enough for its determination. (c) 2006 Elsevier Inc. All rights reserved.
T2  - Journal of Colloid and Interface Science
T1  - Interaction of quinapril anion with cationic surfactant micelles of cetyltrimethylammonium bromide
VL  - 301
IS  - 2
SP  - 692
EP  - 696
DO  - 10.1016/j.jcis.2006.05.025
ER  - 

@article{
author = "Čudina Olivera and Janković, Ivana A. and Čomor, Mirjana and Vladimirov, Sote",
year = "2006",
abstract = "In this study, the interaction of the anion of quinapril (QUIN), angiotensin converting enzyme (ACE) inhibitor, with cationic surfactant cetyltrimethylammonium bromide (CTAB) was investigated. The effect of cationic micelles on the spectroscopic and acid-base properties of QUIN was studied at pH 8. The binding of QUIN anion to CTAB micelles implied a shift in drug acidity constant (pK(a)(water) - pK(a)(micelle) = 1.39) proving the great affinity of negatively charged QUIN ion for the positively charged CTAB micelle surface. The strong dependence of the partition coefficient K-x on QUIN concentration, obtained by using pseudo-phase model, is consistent with an adsorption-like phenomenon. From the dependence of differential absorbance at lambda = 272 nm on CTAB concentration, by using mathematical model that treats the solubilization of QUIN anion as its binding to specific sites in the micelles (Langmuir adsorption isotherm), the binding constant K-b = (2.3 +/- 0.4) x 10(3) mol(-1) dm(3) was obtained. QUIN-CTAB binding constant was also calculated from micellar liquid chromatography (MLC) and this method was found to be not accurate enough for its determination. (c) 2006 Elsevier Inc. All rights reserved.",
journal = "Journal of Colloid and Interface Science",
title = "Interaction of quinapril anion with cationic surfactant micelles of cetyltrimethylammonium bromide",
volume = "301",
number = "2",
pages = "692-696",
doi = "10.1016/j.jcis.2006.05.025"
}

Čudina Olivera, Janković, I. A., Čomor, M.,& Vladimirov, S.. (2006). Interaction of quinapril anion with cationic surfactant micelles of cetyltrimethylammonium bromide. in Journal of Colloid and Interface Science, 301(2), 692-696.
https://doi.org/10.1016/j.jcis.2006.05.025

Čudina Olivera, Janković IA, Čomor M, Vladimirov S. Interaction of quinapril anion with cationic surfactant micelles of cetyltrimethylammonium bromide. in Journal of Colloid and Interface Science. 2006;301(2):692-696.
doi:10.1016/j.jcis.2006.05.025 .

Čudina Olivera, Janković, Ivana A., Čomor, Mirjana, Vladimirov, Sote, "Interaction of quinapril anion with cationic surfactant micelles of cetyltrimethylammonium bromide" in Journal of Colloid and Interface Science, 301, no. 2 (2006):692-696,
https://doi.org/10.1016/j.jcis.2006.05.025 . .

TY  - JOUR
AU  - Čudina, Olivera
AU  - Čomor, Mirjana
AU  - Janković, Ivana A.
PY  - 2005
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/2880
AB  - A simple, precise and sensitive reverse-phase high performance liquid chromatographic (RP-HPLC) method has been developed for the quantitation of bifonazole, an imidazole antifungal, simultaneously with benzyl alcohol, used as preservative, in pharmaceutical formulations. Method employed Zorbax Eclipse XDB-C18 (250x4.6 mm i.d., 5 mu m) column, methanol-ammonium acetate (pH 2; 65 mM) (65:35, v/v, pH(*) 3.6) as mobile phase with flow rate of 1 mL min(-1) and variable UV detection at 220 and 252 nm. The proposed method was validated by testing its linearity, selectivity, recovery, repeatability, LOD/LOQ values and it was successfully employed for the determination of bifonazole and benzyl alcohol in pharmaceutical cream-based formulations.
T2  - Chromatographia
T1  - Simultaneous determination of bifonazole and benzyl alcohol in pharmaceutical formulations by reverse-phase HPLC
VL  - 61
IS  - 7-8
SP  - 415
EP  - 418
DO  - 10.1365/s10337-005-0524-9
ER  - 

@article{
author = "Čudina, Olivera and Čomor, Mirjana and Janković, Ivana A.",
year = "2005",
abstract = "A simple, precise and sensitive reverse-phase high performance liquid chromatographic (RP-HPLC) method has been developed for the quantitation of bifonazole, an imidazole antifungal, simultaneously with benzyl alcohol, used as preservative, in pharmaceutical formulations. Method employed Zorbax Eclipse XDB-C18 (250x4.6 mm i.d., 5 mu m) column, methanol-ammonium acetate (pH 2; 65 mM) (65:35, v/v, pH(*) 3.6) as mobile phase with flow rate of 1 mL min(-1) and variable UV detection at 220 and 252 nm. The proposed method was validated by testing its linearity, selectivity, recovery, repeatability, LOD/LOQ values and it was successfully employed for the determination of bifonazole and benzyl alcohol in pharmaceutical cream-based formulations.",
journal = "Chromatographia",
title = "Simultaneous determination of bifonazole and benzyl alcohol in pharmaceutical formulations by reverse-phase HPLC",
volume = "61",
number = "7-8",
pages = "415-418",
doi = "10.1365/s10337-005-0524-9"
}

Čudina, O., Čomor, M.,& Janković, I. A.. (2005). Simultaneous determination of bifonazole and benzyl alcohol in pharmaceutical formulations by reverse-phase HPLC. in Chromatographia, 61(7-8), 415-418.
https://doi.org/10.1365/s10337-005-0524-9

Čudina O, Čomor M, Janković IA. Simultaneous determination of bifonazole and benzyl alcohol in pharmaceutical formulations by reverse-phase HPLC. in Chromatographia. 2005;61(7-8):415-418.
doi:10.1365/s10337-005-0524-9 .

Čudina, Olivera, Čomor, Mirjana, Janković, Ivana A., "Simultaneous determination of bifonazole and benzyl alcohol in pharmaceutical formulations by reverse-phase HPLC" in Chromatographia, 61, no. 7-8 (2005):415-418,
https://doi.org/10.1365/s10337-005-0524-9 . .

TY  - JOUR
AU  - Čudina, Olivera
AU  - Karljiković-Rajić, Katarina
AU  - Ruvarac-Bugarčić, Ivanka A.
AU  - Janković, Ivana A.
PY  - 2005
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/2878
AB  - In this study, the interaction of hydrochlorothiazide (HCT), benzothiadiazine diuretic, with cationic surfactant cetyltrimethylammonium bromide (CTAB) was investigated. The effect of cationic micelles on the spectroscopic and acid-base properties of HCT was studied at pH 10.5. The binding of HCT to CTAB micelles implied a shift in drug acidity constant (pK(a)(water) - pK(a)(micelle) =0.46) proving the greater affinity of HCT dianion for the positively charged CTAB micelle surface. From the dependence of differential absorbance at lambda = 355 nm on CTAB concentration, by using mathematical model that treats the solubilization of HCT dianion as its binding to specific sites in the micelles (Langmuir adsorption isotherm), the binding constant K-b = (1.17 +/- 0.16) x 10(4) mol(-1) dm(3) was obtained. By using pseudo-phase model, the partition coefficient between the bulk water and CTAB micelles, K-x, was calculated from both differential absorbance Delta A(355), K-x =(6.18 +/- 0.64) x 10(4) mol((1) dm(3), and first-order derivative amplitude D-1(250.1), K-x =(5.47 +/- 0.56) x 10(4) mol((1) dm(3). (c) 2005 Elsevier B.V. All rights reserved.
T2  - Colloids and Surfaces. A: Physicochemical and Engineering Aspects
T1  - Interaction of hydrochlorothiazide with cationic surfactant micelles of cetyltrimethylammonium bromide
VL  - 256
IS  - 2-3
SP  - 225
EP  - 232
DO  - 10.1016/j.colsurfa.2005.01.023
ER  - 

@article{
author = "Čudina, Olivera and Karljiković-Rajić, Katarina and Ruvarac-Bugarčić, Ivanka A. and Janković, Ivana A.",
year = "2005",
abstract = "In this study, the interaction of hydrochlorothiazide (HCT), benzothiadiazine diuretic, with cationic surfactant cetyltrimethylammonium bromide (CTAB) was investigated. The effect of cationic micelles on the spectroscopic and acid-base properties of HCT was studied at pH 10.5. The binding of HCT to CTAB micelles implied a shift in drug acidity constant (pK(a)(water) - pK(a)(micelle) =0.46) proving the greater affinity of HCT dianion for the positively charged CTAB micelle surface. From the dependence of differential absorbance at lambda = 355 nm on CTAB concentration, by using mathematical model that treats the solubilization of HCT dianion as its binding to specific sites in the micelles (Langmuir adsorption isotherm), the binding constant K-b = (1.17 +/- 0.16) x 10(4) mol(-1) dm(3) was obtained. By using pseudo-phase model, the partition coefficient between the bulk water and CTAB micelles, K-x, was calculated from both differential absorbance Delta A(355), K-x =(6.18 +/- 0.64) x 10(4) mol((1) dm(3), and first-order derivative amplitude D-1(250.1), K-x =(5.47 +/- 0.56) x 10(4) mol((1) dm(3). (c) 2005 Elsevier B.V. All rights reserved.",
journal = "Colloids and Surfaces. A: Physicochemical and Engineering Aspects",
title = "Interaction of hydrochlorothiazide with cationic surfactant micelles of cetyltrimethylammonium bromide",
volume = "256",
number = "2-3",
pages = "225-232",
doi = "10.1016/j.colsurfa.2005.01.023"
}

Čudina, O., Karljiković-Rajić, K., Ruvarac-Bugarčić, I. A.,& Janković, I. A.. (2005). Interaction of hydrochlorothiazide with cationic surfactant micelles of cetyltrimethylammonium bromide. in Colloids and Surfaces. A: Physicochemical and Engineering Aspects, 256(2-3), 225-232.
https://doi.org/10.1016/j.colsurfa.2005.01.023

Čudina O, Karljiković-Rajić K, Ruvarac-Bugarčić IA, Janković IA. Interaction of hydrochlorothiazide with cationic surfactant micelles of cetyltrimethylammonium bromide. in Colloids and Surfaces. A: Physicochemical and Engineering Aspects. 2005;256(2-3):225-232.
doi:10.1016/j.colsurfa.2005.01.023 .

Čudina, Olivera, Karljiković-Rajić, Katarina, Ruvarac-Bugarčić, Ivanka A., Janković, Ivana A., "Interaction of hydrochlorothiazide with cationic surfactant micelles of cetyltrimethylammonium bromide" in Colloids and Surfaces. A: Physicochemical and Engineering Aspects, 256, no. 2-3 (2005):225-232,
https://doi.org/10.1016/j.colsurfa.2005.01.023 . .

TY  - CONF
AU  - Čudina, Olivera
AU  - Karljiković-Rajić, Katarina
AU  - Ruvarac-Bugarčić, Ivanka A.
AU  - Janković, Ivana A.
PY  - 2004
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9604
AB  - The interaction of hydrochlorothiazide (HCT), benzothiadiazine diuretic, with cationic surfactant cetyltrimethylammonium bromide (CTAB) was studied as a model system for drug/membrane interactions. From the dependence of first order derivative amplitude 1 D250.1 on CTAB concentration, by using mathematical models based on the partition of the drug between micellar and aqueous pseudo-phase, CTAB/water partition coefficient Kp was calculated.
PB  - Society of Physical Chemists of Serbia
C3  - Physical chemistry 2004: 7th international conference on fundemental and applied aspract of physical chemistry
T1  - Derivative spectrophotometric determination of partition coefficient of hydrochlorothiazide between cetyltrimethylammonium bromide micelles and water
VL  - 2
SP  - 853
EP  - 855
UR  - https://hdl.handle.net/21.15107/rcub_vinar_9604
ER  - 

@conference{
author = "Čudina, Olivera and Karljiković-Rajić, Katarina and Ruvarac-Bugarčić, Ivanka A. and Janković, Ivana A.",
year = "2004",
abstract = "The interaction of hydrochlorothiazide (HCT), benzothiadiazine diuretic, with cationic surfactant cetyltrimethylammonium bromide (CTAB) was studied as a model system for drug/membrane interactions. From the dependence of first order derivative amplitude 1 D250.1 on CTAB concentration, by using mathematical models based on the partition of the drug between micellar and aqueous pseudo-phase, CTAB/water partition coefficient Kp was calculated.",
publisher = "Society of Physical Chemists of Serbia",
journal = "Physical chemistry 2004: 7th international conference on fundemental and applied aspract of physical chemistry",
title = "Derivative spectrophotometric determination of partition coefficient of hydrochlorothiazide between cetyltrimethylammonium bromide micelles and water",
volume = "2",
pages = "853-855",
url = "https://hdl.handle.net/21.15107/rcub_vinar_9604"
}

Čudina, O., Karljiković-Rajić, K., Ruvarac-Bugarčić, I. A.,& Janković, I. A.. (2004). Derivative spectrophotometric determination of partition coefficient of hydrochlorothiazide between cetyltrimethylammonium bromide micelles and water. in Physical chemistry 2004: 7th international conference on fundemental and applied aspract of physical chemistry
Society of Physical Chemists of Serbia., 2, 853-855.
https://hdl.handle.net/21.15107/rcub_vinar_9604

Čudina O, Karljiković-Rajić K, Ruvarac-Bugarčić IA, Janković IA. Derivative spectrophotometric determination of partition coefficient of hydrochlorothiazide between cetyltrimethylammonium bromide micelles and water. in Physical chemistry 2004: 7th international conference on fundemental and applied aspract of physical chemistry. 2004;2:853-855.
https://hdl.handle.net/21.15107/rcub_vinar_9604 .

Čudina, Olivera, Karljiković-Rajić, Katarina, Ruvarac-Bugarčić, Ivanka A., Janković, Ivana A., "Derivative spectrophotometric determination of partition coefficient of hydrochlorothiazide between cetyltrimethylammonium bromide micelles and water" in Physical chemistry 2004: 7th international conference on fundemental and applied aspract of physical chemistry, 2 (2004):853-855,
https://hdl.handle.net/21.15107/rcub_vinar_9604 .

TY  - JOUR
AU  - Vladimirov, Sote
AU  - Čudina, Olivera
AU  - Agbaba, Danica
AU  - Jovanovic, M
AU  - Živanov-Stakić, Dobrila
PY  - 1996
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/7217
AB  - The proposed method is based on coloured hydrazone formation with 1,4-dihydrazinophthalazine as a reagent. Heating at 85 degrees C for 2 h was found necessary to ensure optimal hydrazone formation in the presence of hydrochloric acid. The yellow hydrazone product has an absorption maximum at 380 nm. A linear relationship between absorbance and concentration was established in the concentration range 3.19 x 10(-6)-3.19 x 10(-5) mol l(-1) (the regression equation was y = 0.013 167 3 + 0.019 025 9x; correlation coefficient r = 0.9991; n = 6). The detection limit was 1.2 mu g ml(-1) (molar absorptivity found was 1.97 x 10(4) l mol(-1) cm(-1)). The reliability of the proposed method was checked at three different concentrations; the relative standard deviation (RSD) varied from 1.03 to 2.01%. The described method applied to the determination of desoximetasone in ointment gave precise and reproducible results; the recovery was 98.55% with RSD = 2.40% (n = 10).
T2  - Journal of Pharmaceutical and Biomedical Analysis
T1  - Spectrophotometric determination of desoximetasone in ointment using 1,4-dihydrazinophthalazine
VL  - 14
IS  - 8-10
SP  - 947
EP  - 950
DO  - 10.1016/0731-7085(95)01681-3
ER  - 

@article{
author = "Vladimirov, Sote and Čudina, Olivera and Agbaba, Danica and Jovanovic, M and Živanov-Stakić, Dobrila",
year = "1996",
abstract = "The proposed method is based on coloured hydrazone formation with 1,4-dihydrazinophthalazine as a reagent. Heating at 85 degrees C for 2 h was found necessary to ensure optimal hydrazone formation in the presence of hydrochloric acid. The yellow hydrazone product has an absorption maximum at 380 nm. A linear relationship between absorbance and concentration was established in the concentration range 3.19 x 10(-6)-3.19 x 10(-5) mol l(-1) (the regression equation was y = 0.013 167 3 + 0.019 025 9x; correlation coefficient r = 0.9991; n = 6). The detection limit was 1.2 mu g ml(-1) (molar absorptivity found was 1.97 x 10(4) l mol(-1) cm(-1)). The reliability of the proposed method was checked at three different concentrations; the relative standard deviation (RSD) varied from 1.03 to 2.01%. The described method applied to the determination of desoximetasone in ointment gave precise and reproducible results; the recovery was 98.55% with RSD = 2.40% (n = 10).",
journal = "Journal of Pharmaceutical and Biomedical Analysis",
title = "Spectrophotometric determination of desoximetasone in ointment using 1,4-dihydrazinophthalazine",
volume = "14",
number = "8-10",
pages = "947-950",
doi = "10.1016/0731-7085(95)01681-3"
}

Vladimirov, S., Čudina, O., Agbaba, D., Jovanovic, M.,& Živanov-Stakić, D.. (1996). Spectrophotometric determination of desoximetasone in ointment using 1,4-dihydrazinophthalazine. in Journal of Pharmaceutical and Biomedical Analysis, 14(8-10), 947-950.
https://doi.org/10.1016/0731-7085(95)01681-3

Vladimirov S, Čudina O, Agbaba D, Jovanovic M, Živanov-Stakić D. Spectrophotometric determination of desoximetasone in ointment using 1,4-dihydrazinophthalazine. in Journal of Pharmaceutical and Biomedical Analysis. 1996;14(8-10):947-950.
doi:10.1016/0731-7085(95)01681-3 .

Vladimirov, Sote, Čudina, Olivera, Agbaba, Danica, Jovanovic, M, Živanov-Stakić, Dobrila, "Spectrophotometric determination of desoximetasone in ointment using 1,4-dihydrazinophthalazine" in Journal of Pharmaceutical and Biomedical Analysis, 14, no. 8-10 (1996):947-950,
https://doi.org/10.1016/0731-7085(95)01681-3 . .