TY  - JOUR
AU  - Tomić, Simonida Lj.
AU  - Mićić, Maja M.
AU  - Krezović, Bojana D.
AU  - Dobić, Sava N.
AU  - Suljovrujić, Edin H.
AU  - Filipović, Jovanka M.
PY  - 2009
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/3967
AB  - pH and temperature sensitive hydrogels, based on 2-hydroxyethyl methacrylate (HEMA) and itaconic acid (IA) copolymers, were prepared by gamma irradiation and characterized in order to examine their potential use in biomedical applications. The influence of comonomer ratio in these smart copolymers on their morphology, mechanical properties, biocompatibility and microbe penetration capability was investigated. The mechanical properties of copolymers were investigated using the dynamic mechanical analysis (DMA), while their morphology was examined by scanning electron microscopy (SEM). The morphology and mechanical properties of these hydrogels were found to be suitable for most requirements of biomedical applications. The in vitro study of P(HEMA/IA) biocompatibility showed no evidence of cell toxicity nor any considerable hemolytic activity. Furthermore, the microbe penetration test showed that neither Staphylococcus aureus nor Escherichia coli passed through the hydogel dressing; thus the P(HEMA/IA) dressing could be considered a good barrier against microbes. All results indicate that stimuli-responsive P(HEMA/IA) hydrogels have great potential for biomedical applications, especially for skin treatment and wound dressings.
T2  - Hemijska industrija
T1  - Smart Hydrogels Based on Itaconic Acid for Biomedical Application
VL  - 63
IS  - 6
SP  - 603
EP  - 610
DO  - 10.2298/HEMIND0906603T
ER  - 

@article{
author = "Tomić, Simonida Lj. and Mićić, Maja M. and Krezović, Bojana D. and Dobić, Sava N. and Suljovrujić, Edin H. and Filipović, Jovanka M.",
year = "2009",
abstract = "pH and temperature sensitive hydrogels, based on 2-hydroxyethyl methacrylate (HEMA) and itaconic acid (IA) copolymers, were prepared by gamma irradiation and characterized in order to examine their potential use in biomedical applications. The influence of comonomer ratio in these smart copolymers on their morphology, mechanical properties, biocompatibility and microbe penetration capability was investigated. The mechanical properties of copolymers were investigated using the dynamic mechanical analysis (DMA), while their morphology was examined by scanning electron microscopy (SEM). The morphology and mechanical properties of these hydrogels were found to be suitable for most requirements of biomedical applications. The in vitro study of P(HEMA/IA) biocompatibility showed no evidence of cell toxicity nor any considerable hemolytic activity. Furthermore, the microbe penetration test showed that neither Staphylococcus aureus nor Escherichia coli passed through the hydogel dressing; thus the P(HEMA/IA) dressing could be considered a good barrier against microbes. All results indicate that stimuli-responsive P(HEMA/IA) hydrogels have great potential for biomedical applications, especially for skin treatment and wound dressings.",
journal = "Hemijska industrija",
title = "Smart Hydrogels Based on Itaconic Acid for Biomedical Application",
volume = "63",
number = "6",
pages = "603-610",
doi = "10.2298/HEMIND0906603T"
}

Tomić, S. Lj., Mićić, M. M., Krezović, B. D., Dobić, S. N., Suljovrujić, E. H.,& Filipović, J. M.. (2009). Smart Hydrogels Based on Itaconic Acid for Biomedical Application. in Hemijska industrija, 63(6), 603-610.
https://doi.org/10.2298/HEMIND0906603T

Tomić SL, Mićić MM, Krezović BD, Dobić SN, Suljovrujić EH, Filipović JM. Smart Hydrogels Based on Itaconic Acid for Biomedical Application. in Hemijska industrija. 2009;63(6):603-610.
doi:10.2298/HEMIND0906603T .

Tomić, Simonida Lj., Mićić, Maja M., Krezović, Bojana D., Dobić, Sava N., Suljovrujić, Edin H., Filipović, Jovanka M., "Smart Hydrogels Based on Itaconic Acid for Biomedical Application" in Hemijska industrija, 63, no. 6 (2009):603-610,
https://doi.org/10.2298/HEMIND0906603T . .