TY  - JOUR
AU  - Jovanović, Ivana
AU  - Jordović, Branka
AU  - Petković, Marijana
AU  - Ignjatović, Nenad L.
AU  - Uskoković, Dragan
PY  - 2008
UR  - http://dais.sanu.ac.rs/123456789/177
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/7360
AB  - Biodegradable microspheres such as those made of poly-D,L-lactide (PDLLA) are widely investigated delivery systems for drugs or antigens. The aim of this study was to examine experimental conditions in order to produce PDLLA microspheres with the best properties for controlled and sustained drug delivery by the modified precipitation method. For this purpose, the following parameters were varied: co-solvent (methanol or ethanol), the concentration of stabilizer polyvinyl alcohol (PVA), chloroform-to-water ratio and the speed and time of homogenization. Scanning electron microscopy (SEM) and stereological analysis were used to characterize the particles. The average size and morphology of the microspheres varied substantially with preparation conditions from 8.44–1.25 μm. Results showed that the smallest particles were obtained with methanol, 1% PVA and with 10 min of homogenization at 21,000 rpm. Microsc. Res. Tech., 2008. © 2007 Wiley-Liss, Inc.
PB  - Wiley
T2  - Microscopy Research and Technique
T1  - Preparation of smallest microparticles of poly-D,L-lactide by modified precipitation method: Influence of the process parameters
SP  - 86
EP  - 92
DO  - 10.1002/jemt.20529
ER  - 

@article{
author = "Jovanović, Ivana and Jordović, Branka and Petković, Marijana and Ignjatović, Nenad L. and Uskoković, Dragan",
year = "2008",
abstract = "Biodegradable microspheres such as those made of poly-D,L-lactide (PDLLA) are widely investigated delivery systems for drugs or antigens. The aim of this study was to examine experimental conditions in order to produce PDLLA microspheres with the best properties for controlled and sustained drug delivery by the modified precipitation method. For this purpose, the following parameters were varied: co-solvent (methanol or ethanol), the concentration of stabilizer polyvinyl alcohol (PVA), chloroform-to-water ratio and the speed and time of homogenization. Scanning electron microscopy (SEM) and stereological analysis were used to characterize the particles. The average size and morphology of the microspheres varied substantially with preparation conditions from 8.44–1.25 μm. Results showed that the smallest particles were obtained with methanol, 1% PVA and with 10 min of homogenization at 21,000 rpm. Microsc. Res. Tech., 2008. © 2007 Wiley-Liss, Inc.",
publisher = "Wiley",
journal = "Microscopy Research and Technique",
title = "Preparation of smallest microparticles of poly-D,L-lactide by modified precipitation method: Influence of the process parameters",
pages = "86-92",
doi = "10.1002/jemt.20529"
}

Jovanović, I., Jordović, B., Petković, M., Ignjatović, N. L.,& Uskoković, D.. (2008). Preparation of smallest microparticles of poly-D,L-lactide by modified precipitation method: Influence of the process parameters. in Microscopy Research and Technique
Wiley., 86-92.
https://doi.org/10.1002/jemt.20529

Jovanović I, Jordović B, Petković M, Ignjatović NL, Uskoković D. Preparation of smallest microparticles of poly-D,L-lactide by modified precipitation method: Influence of the process parameters. in Microscopy Research and Technique. 2008;:86-92.
doi:10.1002/jemt.20529 .

Jovanović, Ivana, Jordović, Branka, Petković, Marijana, Ignjatović, Nenad L., Uskoković, Dragan, "Preparation of smallest microparticles of poly-D,L-lactide by modified precipitation method: Influence of the process parameters" in Microscopy Research and Technique (2008):86-92,
https://doi.org/10.1002/jemt.20529 . .

TY  - CONF
AU  - Jovanović, Ivana
AU  - Petković, Marijana
AU  - Vujčić, Zoran
AU  - Jordović, Branka
AU  - Ignjatović, Nenad L.
AU  - Uskoković, Dragan
PY  - 2007
UR  - http://dais.sanu.ac.rs/123456789/319
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/7397
AB  - Poster presented at the 9th Conference of the Yugoslav Materials Research Society - YUCOMAT 2007, Herceg Novi, Crna Gora, September 10-14, 2007.
T1  - PDLLA Microparticles Containing BSA: Effect of Formulation Variables on Size Distribution
UR  - https://hdl.handle.net/21.15107/rcub_vinar_7397
ER  - 

@conference{
author = "Jovanović, Ivana and Petković, Marijana and Vujčić, Zoran and Jordović, Branka and Ignjatović, Nenad L. and Uskoković, Dragan",
year = "2007",
abstract = "Poster presented at the 9th Conference of the Yugoslav Materials Research Society - YUCOMAT 2007, Herceg Novi, Crna Gora, September 10-14, 2007.",
title = "PDLLA Microparticles Containing BSA: Effect of Formulation Variables on Size Distribution",
url = "https://hdl.handle.net/21.15107/rcub_vinar_7397"
}

Jovanović, I., Petković, M., Vujčić, Z., Jordović, B., Ignjatović, N. L.,& Uskoković, D.. (2007). PDLLA Microparticles Containing BSA: Effect of Formulation Variables on Size Distribution. .
https://hdl.handle.net/21.15107/rcub_vinar_7397

Jovanović I, Petković M, Vujčić Z, Jordović B, Ignjatović NL, Uskoković D. PDLLA Microparticles Containing BSA: Effect of Formulation Variables on Size Distribution. 2007;.
https://hdl.handle.net/21.15107/rcub_vinar_7397 .

Jovanović, Ivana, Petković, Marijana, Vujčić, Zoran, Jordović, Branka, Ignjatović, Nenad L., Uskoković, Dragan, "PDLLA Microparticles Containing BSA: Effect of Formulation Variables on Size Distribution" (2007),
https://hdl.handle.net/21.15107/rcub_vinar_7397 .

TY  - CONF
AU  - Jovanović, Ivana
AU  - Stevanović, Magdalena
AU  - Mitrić, Miodrag
AU  - Jordović, Branka
AU  - Ignjatović, Nenad L.
AU  - Uskoković, Dragan
PY  - 2006
UR  - http://dais.sanu.ac.rs/123456789/327
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/7403
AB  - Poster presented at the 8th Conference of Yugoslav Materials Research Society – YUCOMAT 2006, Herceg Novi, Montenegro, September 4-8, 2006.
T1  - The Effect of Processing Parameters on Characteristics of Plla Microspheres
UR  - https://hdl.handle.net/21.15107/rcub_vinar_7403
ER  - 

@conference{
author = "Jovanović, Ivana and Stevanović, Magdalena and Mitrić, Miodrag and Jordović, Branka and Ignjatović, Nenad L. and Uskoković, Dragan",
year = "2006",
abstract = "Poster presented at the 8th Conference of Yugoslav Materials Research Society – YUCOMAT 2006, Herceg Novi, Montenegro, September 4-8, 2006.",
title = "The Effect of Processing Parameters on Characteristics of Plla Microspheres",
url = "https://hdl.handle.net/21.15107/rcub_vinar_7403"
}

Jovanović, I., Stevanović, M., Mitrić, M., Jordović, B., Ignjatović, N. L.,& Uskoković, D.. (2006). The Effect of Processing Parameters on Characteristics of Plla Microspheres. .
https://hdl.handle.net/21.15107/rcub_vinar_7403

Jovanović I, Stevanović M, Mitrić M, Jordović B, Ignjatović NL, Uskoković D. The Effect of Processing Parameters on Characteristics of Plla Microspheres. 2006;.
https://hdl.handle.net/21.15107/rcub_vinar_7403 .

Jovanović, Ivana, Stevanović, Magdalena, Mitrić, Miodrag, Jordović, Branka, Ignjatović, Nenad L., Uskoković, Dragan, "The Effect of Processing Parameters on Characteristics of Plla Microspheres" (2006),
https://hdl.handle.net/21.15107/rcub_vinar_7403 .