TY  - JOUR
AU  - Veljković, Veljko
AU  - Glišić, Sanja
AU  - Perović, Vladimir R.
AU  - Veljković, Milena
AU  - Paessler, Slobodan
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10295
AB  - A novel human coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become the leading threat to global health. An effective antiviral could not only help those still vulnerable to the virus but could be a critical treatment if a virus emerges toward evading coronavirus disease 2019 (COVID-19) vaccines. Despite the significant efforts to test already-approved drugs for their potential to kill the virus, researchers found very few actually worked. Methods: The present report uses the electronic molecular descriptors, the quasi-valence number (AQVN), and the electron-ion interaction potential (EIIP), for the analysis of natural compounds with proven therapeutic activity against the COVID-19. Results: Based on the analysis of the electronic properties of natural compounds which are effective against SARS-CoV-2 virus the simple theoretical criterion for the selection of candidate compounds for the treatment of COVID-19 is proposed. Conclusions: The proposed theoretical criterion can be used for the identification and optimization of new lead compounds for the treatment of the COVID-19 disease and for the selection of the food and food supplements which could have a beneficial effect on COVID-19 patients.
T2  - Frontiers in Bioscience - Landmark
T1  - Simple Theoretical Criterion for Selection of Natural Compounds with Anti-COVID-19 Activity
VL  - 27
IS  - 5
SP  - 152
DO  - 10.31083/j.fbl2705152
ER  - 

@article{
author = "Veljković, Veljko and Glišić, Sanja and Perović, Vladimir R. and Veljković, Milena and Paessler, Slobodan",
year = "2022",
abstract = "A novel human coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become the leading threat to global health. An effective antiviral could not only help those still vulnerable to the virus but could be a critical treatment if a virus emerges toward evading coronavirus disease 2019 (COVID-19) vaccines. Despite the significant efforts to test already-approved drugs for their potential to kill the virus, researchers found very few actually worked. Methods: The present report uses the electronic molecular descriptors, the quasi-valence number (AQVN), and the electron-ion interaction potential (EIIP), for the analysis of natural compounds with proven therapeutic activity against the COVID-19. Results: Based on the analysis of the electronic properties of natural compounds which are effective against SARS-CoV-2 virus the simple theoretical criterion for the selection of candidate compounds for the treatment of COVID-19 is proposed. Conclusions: The proposed theoretical criterion can be used for the identification and optimization of new lead compounds for the treatment of the COVID-19 disease and for the selection of the food and food supplements which could have a beneficial effect on COVID-19 patients.",
journal = "Frontiers in Bioscience - Landmark",
title = "Simple Theoretical Criterion for Selection of Natural Compounds with Anti-COVID-19 Activity",
volume = "27",
number = "5",
pages = "152",
doi = "10.31083/j.fbl2705152"
}

Veljković, V., Glišić, S., Perović, V. R., Veljković, M.,& Paessler, S.. (2022). Simple Theoretical Criterion for Selection of Natural Compounds with Anti-COVID-19 Activity. in Frontiers in Bioscience - Landmark, 27(5), 152.
https://doi.org/10.31083/j.fbl2705152

Veljković V, Glišić S, Perović VR, Veljković M, Paessler S. Simple Theoretical Criterion for Selection of Natural Compounds with Anti-COVID-19 Activity. in Frontiers in Bioscience - Landmark. 2022;27(5):152.
doi:10.31083/j.fbl2705152 .

Veljković, Veljko, Glišić, Sanja, Perović, Vladimir R., Veljković, Milena, Paessler, Slobodan, "Simple Theoretical Criterion for Selection of Natural Compounds with Anti-COVID-19 Activity" in Frontiers in Bioscience - Landmark, 27, no. 5 (2022):152,
https://doi.org/10.31083/j.fbl2705152 . .