Simple Theoretical Criterion for Selection of Natural Compounds with Anti-COVID-19 Activity
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
A novel human coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become the leading threat to global health. An effective antiviral could not only help those still vulnerable to the virus but could be a critical treatment if a virus emerges toward evading coronavirus disease 2019 (COVID-19) vaccines. Despite the significant efforts to test already-approved drugs for their potential to kill the virus, researchers found very few actually worked. Methods: The present report uses the electronic molecular descriptors, the quasi-valence number (AQVN), and the electron-ion interaction potential (EIIP), for the analysis of natural compounds with proven therapeutic activity against the COVID-19. Results: Based on the analysis of the electronic properties of natural compounds which are effective against SARS-CoV-2 virus the simple theoretical criterion for the selection of candidate compounds for the treatment of COVID-19 is proposed. Conclusions: The proposed theoret...ical criterion can be used for the identification and optimization of new lead compounds for the treatment of the COVID-19 disease and for the selection of the food and food supplements which could have a beneficial effect on COVID-19 patients.
Кључне речи:
natural compounds / secondary metabolites / flavonoids / coronavirus / COVID-19 / electron-ion interaction potential / average quasi-valence numberИзвор:
Frontiers in Bioscience - Landmark, 2022, 27, 5, 152-Финансирање / пројекти:
- Ministry of Education, Science and Technological Development of the Republic of Serbia and Biomed Protection Galveston Texas USA
DOI: 10.31083/j.fbl2705152
ISSN: 2768-6701
PubMed: 35638419
WoS: 00080768570002
Scopus: 2-s2.0-85131205291
Колекције
Институција/група
VinčaTY - JOUR AU - Veljković, Veljko AU - Glišić, Sanja AU - Perović, Vladimir R. AU - Veljković, Milena AU - Paessler, Slobodan PY - 2022 UR - https://vinar.vin.bg.ac.rs/handle/123456789/10295 AB - A novel human coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become the leading threat to global health. An effective antiviral could not only help those still vulnerable to the virus but could be a critical treatment if a virus emerges toward evading coronavirus disease 2019 (COVID-19) vaccines. Despite the significant efforts to test already-approved drugs for their potential to kill the virus, researchers found very few actually worked. Methods: The present report uses the electronic molecular descriptors, the quasi-valence number (AQVN), and the electron-ion interaction potential (EIIP), for the analysis of natural compounds with proven therapeutic activity against the COVID-19. Results: Based on the analysis of the electronic properties of natural compounds which are effective against SARS-CoV-2 virus the simple theoretical criterion for the selection of candidate compounds for the treatment of COVID-19 is proposed. Conclusions: The proposed theoretical criterion can be used for the identification and optimization of new lead compounds for the treatment of the COVID-19 disease and for the selection of the food and food supplements which could have a beneficial effect on COVID-19 patients. T2 - Frontiers in Bioscience - Landmark T1 - Simple Theoretical Criterion for Selection of Natural Compounds with Anti-COVID-19 Activity VL - 27 IS - 5 SP - 152 DO - 10.31083/j.fbl2705152 ER -
@article{ author = "Veljković, Veljko and Glišić, Sanja and Perović, Vladimir R. and Veljković, Milena and Paessler, Slobodan", year = "2022", abstract = "A novel human coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become the leading threat to global health. An effective antiviral could not only help those still vulnerable to the virus but could be a critical treatment if a virus emerges toward evading coronavirus disease 2019 (COVID-19) vaccines. Despite the significant efforts to test already-approved drugs for their potential to kill the virus, researchers found very few actually worked. Methods: The present report uses the electronic molecular descriptors, the quasi-valence number (AQVN), and the electron-ion interaction potential (EIIP), for the analysis of natural compounds with proven therapeutic activity against the COVID-19. Results: Based on the analysis of the electronic properties of natural compounds which are effective against SARS-CoV-2 virus the simple theoretical criterion for the selection of candidate compounds for the treatment of COVID-19 is proposed. Conclusions: The proposed theoretical criterion can be used for the identification and optimization of new lead compounds for the treatment of the COVID-19 disease and for the selection of the food and food supplements which could have a beneficial effect on COVID-19 patients.", journal = "Frontiers in Bioscience - Landmark", title = "Simple Theoretical Criterion for Selection of Natural Compounds with Anti-COVID-19 Activity", volume = "27", number = "5", pages = "152", doi = "10.31083/j.fbl2705152" }
Veljković, V., Glišić, S., Perović, V. R., Veljković, M.,& Paessler, S.. (2022). Simple Theoretical Criterion for Selection of Natural Compounds with Anti-COVID-19 Activity. in Frontiers in Bioscience - Landmark, 27(5), 152. https://doi.org/10.31083/j.fbl2705152
Veljković V, Glišić S, Perović VR, Veljković M, Paessler S. Simple Theoretical Criterion for Selection of Natural Compounds with Anti-COVID-19 Activity. in Frontiers in Bioscience - Landmark. 2022;27(5):152. doi:10.31083/j.fbl2705152 .
Veljković, Veljko, Glišić, Sanja, Perović, Vladimir R., Veljković, Milena, Paessler, Slobodan, "Simple Theoretical Criterion for Selection of Natural Compounds with Anti-COVID-19 Activity" in Frontiers in Bioscience - Landmark, 27, no. 5 (2022):152, https://doi.org/10.31083/j.fbl2705152 . .