TY  - CONF
AU  - Đorđević, Neda
AU  - Todorović Vukotić, Nevena
AU  - Korićanac, Lela
AU  - Žakula, Jelena
AU  - Pejić, Snežana
AU  - Pajović, Snežana B.
AU  - Tešević, V.
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12586
AB  - Positive effects of moderate wine consumption in individuals with cardiovascular disease, hypertension, diabetes, and cancers have been shown in numerous epidemiological and clinical studies. This research examined the phenolic content of commercial and two clonal Merlot wines as well as their biological potential. The obtained results indicated that all analyzed samples were a good source of phenolic compounds. Cytotoxicity assay on melanoma (A375) and cervical (HeLa) cancer cell lines have shown that all analyzed wines inhibited the growth of human cancer cells in vitro with differing susceptibility among tested cell lines. Clonal wines in the volume ratio of 10 and 20% showed to be more efficient anti-proliferative agents than commercial wine regarding the A375 cells. This could be connected with higher total phenolic content in clonal wines. The effect of all analyzed samples on the A375 cells was greater compared to HeLa cell line.
PB  - Belgrade : Society of Physical Chemists of Serbia
C3  - 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry - Physical Chemistry 2022 : Book of Abstracts
T1  - Phenolic Composition and Cytotoxic Activity of Red Wine
SP  - 153
EP  - 153
UR  - https://hdl.handle.net/21.15107/rcub_vinar_12586
ER  - 

@conference{
author = "Đorđević, Neda and Todorović Vukotić, Nevena and Korićanac, Lela and Žakula, Jelena and Pejić, Snežana and Pajović, Snežana B. and Tešević, V.",
year = "2022",
abstract = "Positive effects of moderate wine consumption in individuals with cardiovascular disease, hypertension, diabetes, and cancers have been shown in numerous epidemiological and clinical studies. This research examined the phenolic content of commercial and two clonal Merlot wines as well as their biological potential. The obtained results indicated that all analyzed samples were a good source of phenolic compounds. Cytotoxicity assay on melanoma (A375) and cervical (HeLa) cancer cell lines have shown that all analyzed wines inhibited the growth of human cancer cells in vitro with differing susceptibility among tested cell lines. Clonal wines in the volume ratio of 10 and 20% showed to be more efficient anti-proliferative agents than commercial wine regarding the A375 cells. This could be connected with higher total phenolic content in clonal wines. The effect of all analyzed samples on the A375 cells was greater compared to HeLa cell line.",
publisher = "Belgrade : Society of Physical Chemists of Serbia",
journal = "16th International Conference on Fundamental and Applied Aspects of Physical Chemistry - Physical Chemistry 2022 : Book of Abstracts",
title = "Phenolic Composition and Cytotoxic Activity of Red Wine",
pages = "153-153",
url = "https://hdl.handle.net/21.15107/rcub_vinar_12586"
}

Đorđević, N., Todorović Vukotić, N., Korićanac, L., Žakula, J., Pejić, S., Pajović, S. B.,& Tešević, V.. (2022). Phenolic Composition and Cytotoxic Activity of Red Wine. in 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry - Physical Chemistry 2022 : Book of Abstracts
Belgrade : Society of Physical Chemists of Serbia., 153-153.
https://hdl.handle.net/21.15107/rcub_vinar_12586

Đorđević N, Todorović Vukotić N, Korićanac L, Žakula J, Pejić S, Pajović SB, Tešević V. Phenolic Composition and Cytotoxic Activity of Red Wine. in 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry - Physical Chemistry 2022 : Book of Abstracts. 2022;:153-153.
https://hdl.handle.net/21.15107/rcub_vinar_12586 .

Đorđević, Neda, Todorović Vukotić, Nevena, Korićanac, Lela, Žakula, Jelena, Pejić, Snežana, Pajović, Snežana B., Tešević, V., "Phenolic Composition and Cytotoxic Activity of Red Wine" in 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry - Physical Chemistry 2022 : Book of Abstracts (2022):153-153,
https://hdl.handle.net/21.15107/rcub_vinar_12586 .

TY  - CONF
AU  - Đorđević, Neda
AU  - Todorović Vukotić, Nevena
AU  - Korićanac, Lela
AU  - Žakula, Jelena
AU  - Pejić, Snežana
AU  - Tešević, V.
AU  - Pajović, Snežana B.
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12592
AB  - Benefitni efekat crvenog vina na zdravlje ljudi od davnina je poznat. Među alkoholnim pićima crveno vino pokazuje najjači efekat protiv pojave oboljenja povezanih sa oksidativnim stresom, kao što su kardiovaskularna, neurodegenerativna oboljenja, dijabetes i kancer.1 U okviru ove studije ispitan je citotoksični efekat crvenog vina sorte merlo (komercijalno dostupno vino i vina dobijena od klonova VCR1 i VCR101) poreklom iz Crne Gore, berba 2011, u odnosu na ćelijsku liniju kancera pankreasa (PANC-1) i ćelijsku liniju melanoma (A375). Citotoksični efekat vina je određen SRB metodom kroz praćenje ćelijskog preživljavanja kancerskih ćelija 48 sati nakon tretmana sa tri različita zapreminska procenta analiziranih vina (5, 10 i 20%). Dobijeni rezultati su pokazali citotoksični efekat svih analiziranih vina na obe ćelijske linije. Ćelijsko preživljavanje nakon tretmana vinima se kretalo od 36 do 64%. Citotoksični efekat svih vina u odnosu na A375 ćelije je bio veći nego na PANC-1 ćelijsku liniju, što je od posebnog značaja ako se uzme u obzir rezistentnost melanomskih ćelija na postojeće terapeutske tretmane. Takođe, klonska sortna vina su pokazala veći citotoksični efekat na A375 ćelijsku liniju od komercijalno dostupnog vina. Dobijeni rezultati su ukazali da umereno konzumiranje crvenog vina sorte merlo sa specifičnim geografskim poreklom predstavlja dobar izvor bioaktivnih komponenata sa pozitivnim biološkim efektom, što je od posebne važnosti za klonska sortna vina.
PB  - Beograd : Srpsko biološko društvo
C3  - 3. kongres biologa Srbije : osnovna i primenjena istraživanja, metodika nastave : knjiga sažetaka
T1  - Citotoksično dejstvo crvenog vina na tumorske ćelije u in vitro uslovima
SP  - 321
EP  - 321
UR  - https://hdl.handle.net/21.15107/rcub_vinar_12592
ER  - 

@conference{
author = "Đorđević, Neda and Todorović Vukotić, Nevena and Korićanac, Lela and Žakula, Jelena and Pejić, Snežana and Tešević, V. and Pajović, Snežana B.",
year = "2022",
abstract = "Benefitni efekat crvenog vina na zdravlje ljudi od davnina je poznat. Među alkoholnim pićima crveno vino pokazuje najjači efekat protiv pojave oboljenja povezanih sa oksidativnim stresom, kao što su kardiovaskularna, neurodegenerativna oboljenja, dijabetes i kancer.1 U okviru ove studije ispitan je citotoksični efekat crvenog vina sorte merlo (komercijalno dostupno vino i vina dobijena od klonova VCR1 i VCR101) poreklom iz Crne Gore, berba 2011, u odnosu na ćelijsku liniju kancera pankreasa (PANC-1) i ćelijsku liniju melanoma (A375). Citotoksični efekat vina je određen SRB metodom kroz praćenje ćelijskog preživljavanja kancerskih ćelija 48 sati nakon tretmana sa tri različita zapreminska procenta analiziranih vina (5, 10 i 20%). Dobijeni rezultati su pokazali citotoksični efekat svih analiziranih vina na obe ćelijske linije. Ćelijsko preživljavanje nakon tretmana vinima se kretalo od 36 do 64%. Citotoksični efekat svih vina u odnosu na A375 ćelije je bio veći nego na PANC-1 ćelijsku liniju, što je od posebnog značaja ako se uzme u obzir rezistentnost melanomskih ćelija na postojeće terapeutske tretmane. Takođe, klonska sortna vina su pokazala veći citotoksični efekat na A375 ćelijsku liniju od komercijalno dostupnog vina. Dobijeni rezultati su ukazali da umereno konzumiranje crvenog vina sorte merlo sa specifičnim geografskim poreklom predstavlja dobar izvor bioaktivnih komponenata sa pozitivnim biološkim efektom, što je od posebne važnosti za klonska sortna vina.",
publisher = "Beograd : Srpsko biološko društvo",
journal = "3. kongres biologa Srbije : osnovna i primenjena istraživanja, metodika nastave : knjiga sažetaka",
title = "Citotoksično dejstvo crvenog vina na tumorske ćelije u in vitro uslovima",
pages = "321-321",
url = "https://hdl.handle.net/21.15107/rcub_vinar_12592"
}

Đorđević, N., Todorović Vukotić, N., Korićanac, L., Žakula, J., Pejić, S., Tešević, V.,& Pajović, S. B.. (2022). Citotoksično dejstvo crvenog vina na tumorske ćelije u in vitro uslovima. in 3. kongres biologa Srbije : osnovna i primenjena istraživanja, metodika nastave : knjiga sažetaka
Beograd : Srpsko biološko društvo., 321-321.
https://hdl.handle.net/21.15107/rcub_vinar_12592

Đorđević N, Todorović Vukotić N, Korićanac L, Žakula J, Pejić S, Tešević V, Pajović SB. Citotoksično dejstvo crvenog vina na tumorske ćelije u in vitro uslovima. in 3. kongres biologa Srbije : osnovna i primenjena istraživanja, metodika nastave : knjiga sažetaka. 2022;:321-321.
https://hdl.handle.net/21.15107/rcub_vinar_12592 .

Đorđević, Neda, Todorović Vukotić, Nevena, Korićanac, Lela, Žakula, Jelena, Pejić, Snežana, Tešević, V., Pajović, Snežana B., "Citotoksično dejstvo crvenog vina na tumorske ćelije u in vitro uslovima" in 3. kongres biologa Srbije : osnovna i primenjena istraživanja, metodika nastave : knjiga sažetaka (2022):321-321,
https://hdl.handle.net/21.15107/rcub_vinar_12592 .

TY  - CONF
AU  - Đorđević, Neda
AU  - Korićanac, Lela
AU  - Žakula, Jelena
AU  - Todorović Vukotić, Nevena
AU  - Pejić, Snežana
AU  - Tešević, V.
AU  - Pajović, Snežana B.
PY  - 2021
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12583
AB  - Melanoma is responsible for 75% of all deaths from skin cancer. Its lethality arises from its rapid progression, easy metastasis and drug-resistance as well. Red wine is a natural product rich in polyphenolic compounds with potent anticancer activities. It seems that in cancer cells these compounds behave as prooxidants initiating reactive oxygen species mediated cellular DNA breakage and consequent cell death. The aim of this study was to investigate prooxidative activity of red wine samples (Merlot variety, commercial as well as VCR1 and VCR101 clonal wines) in melanoma A375 cells, through measuring the relationship of reduced and oxidized form of glutathione (GSH/GSSG) and comparison with the GSH/GSSG ratio in control (untreated melanoma cells). The data obtained showed that tested red wine samples decrease GSH/GSSG ratio in A375 cells compared to control (4.6 ± 0), with the largest decrease noticed in treatment with VCR101 wine (0.66 ± 0.05).
PB  - The Society of Physical Chemists of Serbia
C3  - 15th International Conference on Fundamental and Applied Aspects of Physical Chemistry - Physical Chemistry 2021 : proceedings, Volume II, September 20-24
T1  - Examination of Prooxidative Activity of Red Wine in Melanoma Cells
SP  - 699
EP  - 702
UR  - https://hdl.handle.net/21.15107/rcub_vinar_12583
ER  - 

@conference{
author = "Đorđević, Neda and Korićanac, Lela and Žakula, Jelena and Todorović Vukotić, Nevena and Pejić, Snežana and Tešević, V. and Pajović, Snežana B.",
year = "2021",
abstract = "Melanoma is responsible for 75% of all deaths from skin cancer. Its lethality arises from its rapid progression, easy metastasis and drug-resistance as well. Red wine is a natural product rich in polyphenolic compounds with potent anticancer activities. It seems that in cancer cells these compounds behave as prooxidants initiating reactive oxygen species mediated cellular DNA breakage and consequent cell death. The aim of this study was to investigate prooxidative activity of red wine samples (Merlot variety, commercial as well as VCR1 and VCR101 clonal wines) in melanoma A375 cells, through measuring the relationship of reduced and oxidized form of glutathione (GSH/GSSG) and comparison with the GSH/GSSG ratio in control (untreated melanoma cells). The data obtained showed that tested red wine samples decrease GSH/GSSG ratio in A375 cells compared to control (4.6 ± 0), with the largest decrease noticed in treatment with VCR101 wine (0.66 ± 0.05).",
publisher = "The Society of Physical Chemists of Serbia",
journal = "15th International Conference on Fundamental and Applied Aspects of Physical Chemistry - Physical Chemistry 2021 : proceedings, Volume II, September 20-24",
title = "Examination of Prooxidative Activity of Red Wine in Melanoma Cells",
pages = "699-702",
url = "https://hdl.handle.net/21.15107/rcub_vinar_12583"
}

Đorđević, N., Korićanac, L., Žakula, J., Todorović Vukotić, N., Pejić, S., Tešević, V.,& Pajović, S. B.. (2021). Examination of Prooxidative Activity of Red Wine in Melanoma Cells. in 15th International Conference on Fundamental and Applied Aspects of Physical Chemistry - Physical Chemistry 2021 : proceedings, Volume II, September 20-24
The Society of Physical Chemists of Serbia., 699-702.
https://hdl.handle.net/21.15107/rcub_vinar_12583

Đorđević N, Korićanac L, Žakula J, Todorović Vukotić N, Pejić S, Tešević V, Pajović SB. Examination of Prooxidative Activity of Red Wine in Melanoma Cells. in 15th International Conference on Fundamental and Applied Aspects of Physical Chemistry - Physical Chemistry 2021 : proceedings, Volume II, September 20-24. 2021;:699-702.
https://hdl.handle.net/21.15107/rcub_vinar_12583 .

Đorđević, Neda, Korićanac, Lela, Žakula, Jelena, Todorović Vukotić, Nevena, Pejić, Snežana, Tešević, V., Pajović, Snežana B., "Examination of Prooxidative Activity of Red Wine in Melanoma Cells" in 15th International Conference on Fundamental and Applied Aspects of Physical Chemistry - Physical Chemistry 2021 : proceedings, Volume II, September 20-24 (2021):699-702,
https://hdl.handle.net/21.15107/rcub_vinar_12583 .