TY  - JOUR
AU  - Trutic, N
AU  - Magic, Z
AU  - Urosevic, N
AU  - Krtolica-Žikić, Koviljka
PY  - 2002
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/2577
AB  - We studied the effect of total body X-irradiation and partial hepatectomy on the acute phase protein gene expression in rat liver. Male rats of AO strain were irradiated with high X-ray doses, without any visible tissue damage. In contrast, partial hepatectomy consisted of surgical removal of 40% liver tissue. The changes in liver mRNA concentrations for positive acute-phase reactants including cysteine protease inhibitor, alpha(1)-acid glycoprotein, fibrinogen and haptoglobin, and albumin as a negative reactant were monitored by Northern blot and slot-blot hybridizations using corresponding [P-32]dCTP labeled cDNA probes. While in the first 24 h after the partial hepatectomy, liver mRNA levels for the positive acute-phase reactants increased, briefly followed by an immediate decrease, the duration and timing of the acute-phase responses to the whole body X-irradiation were slightly different and lasted for as long as 72 h. Although both treatments induced the mRNA expression of acute-phase reactants in rat liver, the observed variations in the duration and intensity of the changes in mRNA levels for the acute-phase proteins in these two types of tissue damage suggest the involvement of specific mechanisms in a fine tuning of the non-specific acute-phase responses to meet the unique requirements of the particular injury. (C) 2002 Elsevier Science Inc. All rights reserved.
T2  - Comparative Biochemistry and Physiology. C: Toxicology and Pharmacology
T1  - Acute-phase protein gene expression in rat liver following whole body X-irradiation or partial hepatectomy
VL  - 133
IS  - 3
SP  - 461
EP  - 470
DO  - 10.1016/S1532-0456(02)00174-6
ER  - 

@article{
author = "Trutic, N and Magic, Z and Urosevic, N and Krtolica-Žikić, Koviljka",
year = "2002",
abstract = "We studied the effect of total body X-irradiation and partial hepatectomy on the acute phase protein gene expression in rat liver. Male rats of AO strain were irradiated with high X-ray doses, without any visible tissue damage. In contrast, partial hepatectomy consisted of surgical removal of 40% liver tissue. The changes in liver mRNA concentrations for positive acute-phase reactants including cysteine protease inhibitor, alpha(1)-acid glycoprotein, fibrinogen and haptoglobin, and albumin as a negative reactant were monitored by Northern blot and slot-blot hybridizations using corresponding [P-32]dCTP labeled cDNA probes. While in the first 24 h after the partial hepatectomy, liver mRNA levels for the positive acute-phase reactants increased, briefly followed by an immediate decrease, the duration and timing of the acute-phase responses to the whole body X-irradiation were slightly different and lasted for as long as 72 h. Although both treatments induced the mRNA expression of acute-phase reactants in rat liver, the observed variations in the duration and intensity of the changes in mRNA levels for the acute-phase proteins in these two types of tissue damage suggest the involvement of specific mechanisms in a fine tuning of the non-specific acute-phase responses to meet the unique requirements of the particular injury. (C) 2002 Elsevier Science Inc. All rights reserved.",
journal = "Comparative Biochemistry and Physiology. C: Toxicology and Pharmacology",
title = "Acute-phase protein gene expression in rat liver following whole body X-irradiation or partial hepatectomy",
volume = "133",
number = "3",
pages = "461-470",
doi = "10.1016/S1532-0456(02)00174-6"
}

Trutic, N., Magic, Z., Urosevic, N.,& Krtolica-Žikić, K.. (2002). Acute-phase protein gene expression in rat liver following whole body X-irradiation or partial hepatectomy. in Comparative Biochemistry and Physiology. C: Toxicology and Pharmacology, 133(3), 461-470.
https://doi.org/10.1016/S1532-0456(02)00174-6

Trutic N, Magic Z, Urosevic N, Krtolica-Žikić K. Acute-phase protein gene expression in rat liver following whole body X-irradiation or partial hepatectomy. in Comparative Biochemistry and Physiology. C: Toxicology and Pharmacology. 2002;133(3):461-470.
doi:10.1016/S1532-0456(02)00174-6 .

Trutic, N, Magic, Z, Urosevic, N, Krtolica-Žikić, Koviljka, "Acute-phase protein gene expression in rat liver following whole body X-irradiation or partial hepatectomy" in Comparative Biochemistry and Physiology. C: Toxicology and Pharmacology, 133, no. 3 (2002):461-470,
https://doi.org/10.1016/S1532-0456(02)00174-6 . .