TY  - JOUR
AU  - Tuszynski, Jack A.
AU  - Satarić, Miljko V.
AU  - Sekulić, Dalibor L.
AU  - Satarić, Bogdan M.
AU  - Zdravković, Slobodan
PY  - 2018
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/8397
AB  - Calcium ions (Ca2+) tune and control numerous diverse aspects of cochlear and vestibular physiological processes. This paper is focused on the Ca2+ control of mechanotransduction in sensory hair cells in the context of polyelectrolyte properties of actin filaments within the hair–bundles of inner ear. These actin filaments appear to serve as efficient pathways for the flow of Ca2+ ions inside stereocilia. We showed how this can be utilized for tuning of force–generating myosin motors. In an established model, we unified the Ca2+ nonlinear dynamics involved in the control of myosin adaptation motors with mechanical displacements of hair–bundles. The model shows that the characteristic time scales fit reasonably well with the available experimental data for spontaneous oscillations in the inner ear. This scenario promises to fill a gap in our understanding of the role of Ca2+ ions in the regulation of processes in the auditory cells of the inner ear. © 2018 Elsevier B.V.
T2  - Biosystems
T1  - Nonlinear calcium ion waves along actin filaments control active hair–bundle motility
VL  - 173
SP  - 181
EP  - 190
DO  - 10.1016/j.biosystems.2018.08.006
ER  - 

@article{
author = "Tuszynski, Jack A. and Satarić, Miljko V. and Sekulić, Dalibor L. and Satarić, Bogdan M. and Zdravković, Slobodan",
year = "2018",
abstract = "Calcium ions (Ca2+) tune and control numerous diverse aspects of cochlear and vestibular physiological processes. This paper is focused on the Ca2+ control of mechanotransduction in sensory hair cells in the context of polyelectrolyte properties of actin filaments within the hair–bundles of inner ear. These actin filaments appear to serve as efficient pathways for the flow of Ca2+ ions inside stereocilia. We showed how this can be utilized for tuning of force–generating myosin motors. In an established model, we unified the Ca2+ nonlinear dynamics involved in the control of myosin adaptation motors with mechanical displacements of hair–bundles. The model shows that the characteristic time scales fit reasonably well with the available experimental data for spontaneous oscillations in the inner ear. This scenario promises to fill a gap in our understanding of the role of Ca2+ ions in the regulation of processes in the auditory cells of the inner ear. © 2018 Elsevier B.V.",
journal = "Biosystems",
title = "Nonlinear calcium ion waves along actin filaments control active hair–bundle motility",
volume = "173",
pages = "181-190",
doi = "10.1016/j.biosystems.2018.08.006"
}

Tuszynski, J. A., Satarić, M. V., Sekulić, D. L., Satarić, B. M.,& Zdravković, S.. (2018). Nonlinear calcium ion waves along actin filaments control active hair–bundle motility. in Biosystems, 173, 181-190.
https://doi.org/10.1016/j.biosystems.2018.08.006

Tuszynski JA, Satarić MV, Sekulić DL, Satarić BM, Zdravković S. Nonlinear calcium ion waves along actin filaments control active hair–bundle motility. in Biosystems. 2018;173:181-190.
doi:10.1016/j.biosystems.2018.08.006 .

Tuszynski, Jack A., Satarić, Miljko V., Sekulić, Dalibor L., Satarić, Bogdan M., Zdravković, Slobodan, "Nonlinear calcium ion waves along actin filaments control active hair–bundle motility" in Biosystems, 173 (2018):181-190,
https://doi.org/10.1016/j.biosystems.2018.08.006 . .

TY  - JOUR
AU  - Satarić, Miljko V.
AU  - Zdravković, Slobodan
AU  - Tuszynski, Jack A.
PY  - 2011
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/4628
AB  - Cellular long-range transport involves motor proteins (MPs) (especially, kinesin and myosin) which contain a so-called relay helix. Its motion is of crucial importance to the conversion of chemical energy released in ATP hydrolysis into the coordinated mechanical movement of the entire motor protein. In this paper, we propose two combined nonlinear mechanisms for this particular functional activity and suggest the application of neutron scattering assays to experimentally determine the incoherent dynamic structure factor S(q, omega). We argue that this type of experiment is not only feasible but it could offer significant insights into the mechanism of MP function at a molecular level.
T2  - Chaos
T1  - Modeling of relay helix functional dynamics and feasibility of experimental verification by neutron scattering
VL  - 21
IS  - 4
DO  - 10.1063/1.3665091
ER  - 

@article{
author = "Satarić, Miljko V. and Zdravković, Slobodan and Tuszynski, Jack A.",
year = "2011",
abstract = "Cellular long-range transport involves motor proteins (MPs) (especially, kinesin and myosin) which contain a so-called relay helix. Its motion is of crucial importance to the conversion of chemical energy released in ATP hydrolysis into the coordinated mechanical movement of the entire motor protein. In this paper, we propose two combined nonlinear mechanisms for this particular functional activity and suggest the application of neutron scattering assays to experimentally determine the incoherent dynamic structure factor S(q, omega). We argue that this type of experiment is not only feasible but it could offer significant insights into the mechanism of MP function at a molecular level.",
journal = "Chaos",
title = "Modeling of relay helix functional dynamics and feasibility of experimental verification by neutron scattering",
volume = "21",
number = "4",
doi = "10.1063/1.3665091"
}

Satarić, M. V., Zdravković, S.,& Tuszynski, J. A.. (2011). Modeling of relay helix functional dynamics and feasibility of experimental verification by neutron scattering. in Chaos, 21(4).
https://doi.org/10.1063/1.3665091

Satarić MV, Zdravković S, Tuszynski JA. Modeling of relay helix functional dynamics and feasibility of experimental verification by neutron scattering. in Chaos. 2011;21(4).
doi:10.1063/1.3665091 .

Satarić, Miljko V., Zdravković, Slobodan, Tuszynski, Jack A., "Modeling of relay helix functional dynamics and feasibility of experimental verification by neutron scattering" in Chaos, 21, no. 4 (2011),
https://doi.org/10.1063/1.3665091 . .

TY  - JOUR
AU  - Satarić, Miljko V.
AU  - Zeković, Slobodan
AU  - Tuszynski, Jack A.
AU  - Pokorny, J
PY  - 1998
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/2207
AB  - We investigate the electronic degrees of freedom in cytoskeletal microtubules in the continuum approximation. The equations of motion of the propagating local conformational state are solved in the low temperature regime. The solution, which is a kink excitation, is coupled to the motion of the mobile electron of the constituent tubulin. We calculate the influence of kink excitations on the probability of the Mossbauer emission of gamma-active nuclei. A discussion follows on this potentially useful experimental tool for the detection of nonlinear excitations in a microtubule. [S1063-651X(98)14810-9].
T2  - Physical Review E
T1  - Mossbauer effect as a possible tool in detecting nonlinear excitations in microtubules
VL  - 58
IS  - 5
SP  - 6333
EP  - 6339
DO  - 10.1103/PhysRevE.58.6333
ER  - 

@article{
author = "Satarić, Miljko V. and Zeković, Slobodan and Tuszynski, Jack A. and Pokorny, J",
year = "1998",
abstract = "We investigate the electronic degrees of freedom in cytoskeletal microtubules in the continuum approximation. The equations of motion of the propagating local conformational state are solved in the low temperature regime. The solution, which is a kink excitation, is coupled to the motion of the mobile electron of the constituent tubulin. We calculate the influence of kink excitations on the probability of the Mossbauer emission of gamma-active nuclei. A discussion follows on this potentially useful experimental tool for the detection of nonlinear excitations in a microtubule. [S1063-651X(98)14810-9].",
journal = "Physical Review E",
title = "Mossbauer effect as a possible tool in detecting nonlinear excitations in microtubules",
volume = "58",
number = "5",
pages = "6333-6339",
doi = "10.1103/PhysRevE.58.6333"
}

Satarić, M. V., Zeković, S., Tuszynski, J. A.,& Pokorny, J.. (1998). Mossbauer effect as a possible tool in detecting nonlinear excitations in microtubules. in Physical Review E, 58(5), 6333-6339.
https://doi.org/10.1103/PhysRevE.58.6333

Satarić MV, Zeković S, Tuszynski JA, Pokorny J. Mossbauer effect as a possible tool in detecting nonlinear excitations in microtubules. in Physical Review E. 1998;58(5):6333-6339.
doi:10.1103/PhysRevE.58.6333 .

Satarić, Miljko V., Zeković, Slobodan, Tuszynski, Jack A., Pokorny, J, "Mossbauer effect as a possible tool in detecting nonlinear excitations in microtubules" in Physical Review E, 58, no. 5 (1998):6333-6339,
https://doi.org/10.1103/PhysRevE.58.6333 . .