Milenković, Mila

Link to this page

Authority KeyName Variants
orcid::0000-0001-8165-3553
  • Milenković, Mila (6)
Projects

Author's Bibliography

Blue-light-driven photoactivity of L-cysteine-modified graphene quantum dots and their antibacterial effects

Milenković, Mila; Ciasca, Gabriele; Bonasera, Aurelio; Scopelliti, Michelangelo; Marković, Olivera; Verbić, Tatjana; Todorović Marković, Biljana; Jovanović, Svetlana

(2024)

TY  - JOUR
AU  - Milenković, Mila
AU  - Ciasca, Gabriele
AU  - Bonasera, Aurelio
AU  - Scopelliti, Michelangelo
AU  - Marković, Olivera
AU  - Verbić, Tatjana
AU  - Todorović Marković, Biljana
AU  - Jovanović, Svetlana
PY  - 2024
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12238
AB  - The widespread abuse of traditional antibiotics has led to a global rise in antibiotic-resistant bacteria, which give in return unprecedented health risks. Therefore, there is a large and urgent need for the development of new, smart antibacterial agents able to efficiently kill or inhibit bacterial growth. In this study, we investigated the antibacterial activity of S, N-doped Graphene Quantum Dots (GQDs) as a light-triggered antibacterial agent. Gamma irradiation was employed as a tool to achieve one-step modification of GQDs in the presence of L cysteine amino acid as a source of heteroatoms. X-ray Photoelectron Spectroscopy (XPS), nuclear magnetic resonance (NMR), and zeta potential measurements provided the necessary data to clarify the structure of modified dots and verify the introduction of both S- and N-atoms in GQDs structure, but also severe changes in the aromatic, sp2 domains. Namely, γ-irradiation caused a bonding of S atoms in 1.14 at.% mainly as thiol groups, and N in 1.81 at.% as amino groups, but sp2 contribution in GQD structure was lowered from 63.00 to 4.86 at.%, as measured in dots irradiated at a dose of 200 kGy. Fluorescence quenching measurements showed that L-cysteine-modified dots are able to bind to human serum albumin. The antibacterial activity of GQDs combined with 1 and 6 h of blue light (470 nm) irradiation was tested against 8 bacterial strains. GQD-cys-25 sample provided the best results, with minimum inhibitory concentration (MIC) as low as 125 μg/mL against S. aureus, E. faecalis, and E. coli after only 1 h of blue light exposure.
T2  - Journal of Photochemistry & Photobiology, B: Biology
T1  - Blue-light-driven photoactivity of L-cysteine-modified graphene quantum  dots and their antibacterial effects
VL  - 250
SP  - 112818
DO  - 10.1016/j.jphotobiol.2023.112818
ER  - 
@article{
author = "Milenković, Mila and Ciasca, Gabriele and Bonasera, Aurelio and Scopelliti, Michelangelo and Marković, Olivera and Verbić, Tatjana and Todorović Marković, Biljana and Jovanović, Svetlana",
year = "2024",
abstract = "The widespread abuse of traditional antibiotics has led to a global rise in antibiotic-resistant bacteria, which give in return unprecedented health risks. Therefore, there is a large and urgent need for the development of new, smart antibacterial agents able to efficiently kill or inhibit bacterial growth. In this study, we investigated the antibacterial activity of S, N-doped Graphene Quantum Dots (GQDs) as a light-triggered antibacterial agent. Gamma irradiation was employed as a tool to achieve one-step modification of GQDs in the presence of L cysteine amino acid as a source of heteroatoms. X-ray Photoelectron Spectroscopy (XPS), nuclear magnetic resonance (NMR), and zeta potential measurements provided the necessary data to clarify the structure of modified dots and verify the introduction of both S- and N-atoms in GQDs structure, but also severe changes in the aromatic, sp2 domains. Namely, γ-irradiation caused a bonding of S atoms in 1.14 at.% mainly as thiol groups, and N in 1.81 at.% as amino groups, but sp2 contribution in GQD structure was lowered from 63.00 to 4.86 at.%, as measured in dots irradiated at a dose of 200 kGy. Fluorescence quenching measurements showed that L-cysteine-modified dots are able to bind to human serum albumin. The antibacterial activity of GQDs combined with 1 and 6 h of blue light (470 nm) irradiation was tested against 8 bacterial strains. GQD-cys-25 sample provided the best results, with minimum inhibitory concentration (MIC) as low as 125 μg/mL against S. aureus, E. faecalis, and E. coli after only 1 h of blue light exposure.",
journal = "Journal of Photochemistry & Photobiology, B: Biology",
title = "Blue-light-driven photoactivity of L-cysteine-modified graphene quantum  dots and their antibacterial effects",
volume = "250",
pages = "112818",
doi = "10.1016/j.jphotobiol.2023.112818"
}
Milenković, M., Ciasca, G., Bonasera, A., Scopelliti, M., Marković, O., Verbić, T., Todorović Marković, B.,& Jovanović, S.. (2024). Blue-light-driven photoactivity of L-cysteine-modified graphene quantum  dots and their antibacterial effects. in Journal of Photochemistry & Photobiology, B: Biology, 250, 112818.
https://doi.org/10.1016/j.jphotobiol.2023.112818
Milenković M, Ciasca G, Bonasera A, Scopelliti M, Marković O, Verbić T, Todorović Marković B, Jovanović S. Blue-light-driven photoactivity of L-cysteine-modified graphene quantum  dots and their antibacterial effects. in Journal of Photochemistry & Photobiology, B: Biology. 2024;250:112818.
doi:10.1016/j.jphotobiol.2023.112818 .
Milenković, Mila, Ciasca, Gabriele, Bonasera, Aurelio, Scopelliti, Michelangelo, Marković, Olivera, Verbić, Tatjana, Todorović Marković, Biljana, Jovanović, Svetlana, "Blue-light-driven photoactivity of L-cysteine-modified graphene quantum  dots and their antibacterial effects" in Journal of Photochemistry & Photobiology, B: Biology, 250 (2024):112818,
https://doi.org/10.1016/j.jphotobiol.2023.112818 . .

Microwave Electromagnetic Shielding with Free-Standing Composites Based on Graphene Oxide and Silver Nanowires

Kleut, Duška; Milenković, Mila; Von Kleist-Retzow, Fabian; Sebbache, Mohamed; Haddadi, Kamel; Jovanović, Svetlana

(IEEE : Institute of Electrical and Electronics Engineers, 2023)

TY  - CONF
AU  - Kleut, Duška
AU  - Milenković, Mila
AU  - Von Kleist-Retzow, Fabian
AU  - Sebbache, Mohamed
AU  - Haddadi, Kamel
AU  - Jovanović, Svetlana
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12212
AB  - With the growing penetration of microwave applications in modern society, exposure to electromagnetic waves (EMWs) may become an important public health problem. In addition, the coexistence of high frequency devices and systems induce electromagnetic Interferences (EMIs) leading to electromagnetic pertubations and lifetime reduction. consequently, shielding materials capable of blocking EMWs are highly needed. In this paper, composite materials based on graphene oxides and silver nanowires were studied as potential EMW shielding materials. Composites were obtained from graphene oxide (GO) with sheet size between 150 and 2000 nm and thicknesses of flakes in range 2–5 nm. Average thickness of free-standing films were around 14.8 μm . We studied the ratio between these nanomaterials to modulate shielding efficiency in a broad microwave frequency range up to 18 GHz. The shielding efficiency of around 6.5 dB was measured for the r-GO free-standing film.
PB  - IEEE : Institute of Electrical and Electronics Engineers
C3  - MARSS 2023 : 6th International Conference on Manipulation, Automation and Robotics at Small Scales : Proceedings
T1  - Microwave Electromagnetic Shielding with Free-Standing Composites Based on Graphene Oxide and Silver Nanowires
SP  - 1
EP  - 6
DO  - 10.1109/MARSS58567.2023.10294133
ER  - 
@conference{
author = "Kleut, Duška and Milenković, Mila and Von Kleist-Retzow, Fabian and Sebbache, Mohamed and Haddadi, Kamel and Jovanović, Svetlana",
year = "2023",
abstract = "With the growing penetration of microwave applications in modern society, exposure to electromagnetic waves (EMWs) may become an important public health problem. In addition, the coexistence of high frequency devices and systems induce electromagnetic Interferences (EMIs) leading to electromagnetic pertubations and lifetime reduction. consequently, shielding materials capable of blocking EMWs are highly needed. In this paper, composite materials based on graphene oxides and silver nanowires were studied as potential EMW shielding materials. Composites were obtained from graphene oxide (GO) with sheet size between 150 and 2000 nm and thicknesses of flakes in range 2–5 nm. Average thickness of free-standing films were around 14.8 μm . We studied the ratio between these nanomaterials to modulate shielding efficiency in a broad microwave frequency range up to 18 GHz. The shielding efficiency of around 6.5 dB was measured for the r-GO free-standing film.",
publisher = "IEEE : Institute of Electrical and Electronics Engineers",
journal = "MARSS 2023 : 6th International Conference on Manipulation, Automation and Robotics at Small Scales : Proceedings",
title = "Microwave Electromagnetic Shielding with Free-Standing Composites Based on Graphene Oxide and Silver Nanowires",
pages = "1-6",
doi = "10.1109/MARSS58567.2023.10294133"
}
Kleut, D., Milenković, M., Von Kleist-Retzow, F., Sebbache, M., Haddadi, K.,& Jovanović, S.. (2023). Microwave Electromagnetic Shielding with Free-Standing Composites Based on Graphene Oxide and Silver Nanowires. in MARSS 2023 : 6th International Conference on Manipulation, Automation and Robotics at Small Scales : Proceedings
IEEE : Institute of Electrical and Electronics Engineers., 1-6.
https://doi.org/10.1109/MARSS58567.2023.10294133
Kleut D, Milenković M, Von Kleist-Retzow F, Sebbache M, Haddadi K, Jovanović S. Microwave Electromagnetic Shielding with Free-Standing Composites Based on Graphene Oxide and Silver Nanowires. in MARSS 2023 : 6th International Conference on Manipulation, Automation and Robotics at Small Scales : Proceedings. 2023;:1-6.
doi:10.1109/MARSS58567.2023.10294133 .
Kleut, Duška, Milenković, Mila, Von Kleist-Retzow, Fabian, Sebbache, Mohamed, Haddadi, Kamel, Jovanović, Svetlana, "Microwave Electromagnetic Shielding with Free-Standing Composites Based on Graphene Oxide and Silver Nanowires" in MARSS 2023 : 6th International Conference on Manipulation, Automation and Robotics at Small Scales : Proceedings (2023):1-6,
https://doi.org/10.1109/MARSS58567.2023.10294133 . .

Innovative modifications of graphene quantum dots for improved photodynamic therapy in antibacterial treatment

Milenković, Mila; Dorontić, Slađana; Todorović Marković, Biljana; Jovanović, Svetlana

(Belgrade : Institute of Technical Sciences of SASA, 2023)

TY  - CONF
AU  - Milenković, Mila
AU  - Dorontić, Slađana
AU  - Todorović Marković, Biljana
AU  - Jovanović, Svetlana
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12322
AB  - Considering the rising concern of antibiotic resistance, developing advanced antibacterial solutions is highly needed. The ability of graphene quantum dots (GQDs) to generate reactive oxygen species (ROS) upon light exposure made them promising candidates as agents in photodynamic therapy for combatting infections, including antibiotic-resistant strains. GQDs show versatile chemical, physical, and biological properties such as high fluorescent activity, resistance to photo-bleaching, low toxicity, excellent solubility, and biocompatibility. This research focused on exploring the ability of GQDs to produce singlet oxygen under blue light exposure. We used two singlet oxygen probes, 9,10-anthracenediylbis(methylene) dimalonic acid and 1,3-diphenylisobenzofuran to study photoinduced production radicals from several GQDs. To tune the ability of GQDs to generate ROS, we used gamma irradiation in two different media, the presence of L-cysteine and cyclopentanone. The results showed improvements in singlet oxygen production in both cases. However, the modification conducted with cyclopentanol showed notably higher efficacy in promoting singlet oxygen production. This research demonstrates the increasing significance of GQDs in discovering new methods to combat bacteria. The modification of GQDs with gamma irradiation leads to increased production of singlet oxygen enhancing the effectiveness of photodynamic therapy for treating infections.
PB  - Belgrade : Institute of Technical Sciences of SASA
C3  - 21st Young Researchers' Conference Materials Sciences and Engineering : program and the book of abstracts
T1  - Innovative modifications of graphene quantum dots for improved photodynamic therapy in antibacterial treatment
SP  - 49
EP  - 49
UR  - https://hdl.handle.net/21.15107/rcub_vinar_12322
ER  - 
@conference{
author = "Milenković, Mila and Dorontić, Slađana and Todorović Marković, Biljana and Jovanović, Svetlana",
year = "2023",
abstract = "Considering the rising concern of antibiotic resistance, developing advanced antibacterial solutions is highly needed. The ability of graphene quantum dots (GQDs) to generate reactive oxygen species (ROS) upon light exposure made them promising candidates as agents in photodynamic therapy for combatting infections, including antibiotic-resistant strains. GQDs show versatile chemical, physical, and biological properties such as high fluorescent activity, resistance to photo-bleaching, low toxicity, excellent solubility, and biocompatibility. This research focused on exploring the ability of GQDs to produce singlet oxygen under blue light exposure. We used two singlet oxygen probes, 9,10-anthracenediylbis(methylene) dimalonic acid and 1,3-diphenylisobenzofuran to study photoinduced production radicals from several GQDs. To tune the ability of GQDs to generate ROS, we used gamma irradiation in two different media, the presence of L-cysteine and cyclopentanone. The results showed improvements in singlet oxygen production in both cases. However, the modification conducted with cyclopentanol showed notably higher efficacy in promoting singlet oxygen production. This research demonstrates the increasing significance of GQDs in discovering new methods to combat bacteria. The modification of GQDs with gamma irradiation leads to increased production of singlet oxygen enhancing the effectiveness of photodynamic therapy for treating infections.",
publisher = "Belgrade : Institute of Technical Sciences of SASA",
journal = "21st Young Researchers' Conference Materials Sciences and Engineering : program and the book of abstracts",
title = "Innovative modifications of graphene quantum dots for improved photodynamic therapy in antibacterial treatment",
pages = "49-49",
url = "https://hdl.handle.net/21.15107/rcub_vinar_12322"
}
Milenković, M., Dorontić, S., Todorović Marković, B.,& Jovanović, S.. (2023). Innovative modifications of graphene quantum dots for improved photodynamic therapy in antibacterial treatment. in 21st Young Researchers' Conference Materials Sciences and Engineering : program and the book of abstracts
Belgrade : Institute of Technical Sciences of SASA., 49-49.
https://hdl.handle.net/21.15107/rcub_vinar_12322
Milenković M, Dorontić S, Todorović Marković B, Jovanović S. Innovative modifications of graphene quantum dots for improved photodynamic therapy in antibacterial treatment. in 21st Young Researchers' Conference Materials Sciences and Engineering : program and the book of abstracts. 2023;:49-49.
https://hdl.handle.net/21.15107/rcub_vinar_12322 .
Milenković, Mila, Dorontić, Slađana, Todorović Marković, Biljana, Jovanović, Svetlana, "Innovative modifications of graphene quantum dots for improved photodynamic therapy in antibacterial treatment" in 21st Young Researchers' Conference Materials Sciences and Engineering : program and the book of abstracts (2023):49-49,
https://hdl.handle.net/21.15107/rcub_vinar_12322 .

Facile synthesis of L-cysteine functionalized graphene quantum dots as a bioimaging and photosensitive agent

Milenković, Mila; Mišović, Aleksandra; Jovanović, Dragana J.; Popović-Bijelić, Ana D.; Ciasca, Gabriele; Romanò, Sabrina; Bonasera, Aurelio; Mojsin, Marija; Pejić, Jelena; Stevanović, Milena J.; Jovanović, Svetlana P.

(2021)

TY  - JOUR
AU  - Milenković, Mila
AU  - Mišović, Aleksandra
AU  - Jovanović, Dragana J.
AU  - Popović-Bijelić, Ana D.
AU  - Ciasca, Gabriele
AU  - Romanò, Sabrina
AU  - Bonasera, Aurelio
AU  - Mojsin, Marija
AU  - Pejić, Jelena
AU  - Stevanović, Milena J.
AU  - Jovanović, Svetlana P.
PY  - 2021
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9873
AB  - Nowadays, a larger number of aggressive and corrosive chemical reagents as well as toxic solvents are used to achieve structural modification and cleaning of the final products. These lead to the production of residual, waste chemicals, which are often reactive, cancerogenic, and toxic to the environment. This study shows a new approach to the modification of graphene quantum dots (GQDs) using gamma irradiation where the usage of reagents was avoided. We achieved the incorporation of S and N atoms in the GQD structure by selecting an aqueous solution of L-cysteine as an irradiation medium. GQDs were exposed to gamma-irradiation at doses of 25, 50 and 200 kGy. After irradiation, the optical, structural, and morphological properties, as well as the possibility of their use as an agent in bioimaging and photodynamic therapy, were studied. We measured an enhanced quantum yield of photoluminescence with the highest dose of 25 kGy (21.60%). Both S- and N-functional groups were detected in all gamma-irradiated GQDs: amino, amide, thiol, and thione. Spin trap electron paramagnetic resonance showed that GQDs irradiated with 25 kGy can generate singlet oxygen upon illumination. Bioimaging on HeLa cells showed the best visibility for cells treated with GQDs irradiated with 25 kGy, while cytotoxicity was not detected after treatment of HeLa cells with gamma-irradiated GQDs.
T2  - Nanomaterials
T1  - Facile synthesis of L-cysteine functionalized graphene quantum dots as a bioimaging and photosensitive agent
VL  - 11
IS  - 8
SP  - 1879
DO  - 10.3390/nano11081879
ER  - 
@article{
author = "Milenković, Mila and Mišović, Aleksandra and Jovanović, Dragana J. and Popović-Bijelić, Ana D. and Ciasca, Gabriele and Romanò, Sabrina and Bonasera, Aurelio and Mojsin, Marija and Pejić, Jelena and Stevanović, Milena J. and Jovanović, Svetlana P.",
year = "2021",
abstract = "Nowadays, a larger number of aggressive and corrosive chemical reagents as well as toxic solvents are used to achieve structural modification and cleaning of the final products. These lead to the production of residual, waste chemicals, which are often reactive, cancerogenic, and toxic to the environment. This study shows a new approach to the modification of graphene quantum dots (GQDs) using gamma irradiation where the usage of reagents was avoided. We achieved the incorporation of S and N atoms in the GQD structure by selecting an aqueous solution of L-cysteine as an irradiation medium. GQDs were exposed to gamma-irradiation at doses of 25, 50 and 200 kGy. After irradiation, the optical, structural, and morphological properties, as well as the possibility of their use as an agent in bioimaging and photodynamic therapy, were studied. We measured an enhanced quantum yield of photoluminescence with the highest dose of 25 kGy (21.60%). Both S- and N-functional groups were detected in all gamma-irradiated GQDs: amino, amide, thiol, and thione. Spin trap electron paramagnetic resonance showed that GQDs irradiated with 25 kGy can generate singlet oxygen upon illumination. Bioimaging on HeLa cells showed the best visibility for cells treated with GQDs irradiated with 25 kGy, while cytotoxicity was not detected after treatment of HeLa cells with gamma-irradiated GQDs.",
journal = "Nanomaterials",
title = "Facile synthesis of L-cysteine functionalized graphene quantum dots as a bioimaging and photosensitive agent",
volume = "11",
number = "8",
pages = "1879",
doi = "10.3390/nano11081879"
}
Milenković, M., Mišović, A., Jovanović, D. J., Popović-Bijelić, A. D., Ciasca, G., Romanò, S., Bonasera, A., Mojsin, M., Pejić, J., Stevanović, M. J.,& Jovanović, S. P.. (2021). Facile synthesis of L-cysteine functionalized graphene quantum dots as a bioimaging and photosensitive agent. in Nanomaterials, 11(8), 1879.
https://doi.org/10.3390/nano11081879
Milenković M, Mišović A, Jovanović DJ, Popović-Bijelić AD, Ciasca G, Romanò S, Bonasera A, Mojsin M, Pejić J, Stevanović MJ, Jovanović SP. Facile synthesis of L-cysteine functionalized graphene quantum dots as a bioimaging and photosensitive agent. in Nanomaterials. 2021;11(8):1879.
doi:10.3390/nano11081879 .
Milenković, Mila, Mišović, Aleksandra, Jovanović, Dragana J., Popović-Bijelić, Ana D., Ciasca, Gabriele, Romanò, Sabrina, Bonasera, Aurelio, Mojsin, Marija, Pejić, Jelena, Stevanović, Milena J., Jovanović, Svetlana P., "Facile synthesis of L-cysteine functionalized graphene quantum dots as a bioimaging and photosensitive agent" in Nanomaterials, 11, no. 8 (2021):1879,
https://doi.org/10.3390/nano11081879 . .
5
13
2
10

Enhanced photoluminescence of gamma-irradiated S, N graphene quantum dots

Milenković, Mila; Kleut, Duška; Jovanović, Svetlana P.

(Belgrade : Institute of Physics Belgrade, 2021)

TY  - CONF
AU  - Milenković, Mila
AU  - Kleut, Duška
AU  - Jovanović, Svetlana P.
PY  - 2021
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10907
AB  - Zero-dimensional graphene quantum dots (GQDs) are one of the most promising luminescent carbonderived nanomaterials with different oxygen-containing functional groups on their surface. They consist of one or few layers of graphene and have a lateral dimension below 100 nm. Some of their distinct and superior physical and chemical properties such as tunable photoluminescence, good biocompatibility, low toxicity, and excellent dispersibility in water, make them a promising candidate for biomedical applications [1]. With the functionalization of GQDs, it is possible to modify their surface structure by adding other functional groups thus altering photoluminescence and enhancing their other properties [2]. Gamma irradiation proved to be a simple and eco-friendly method for subsequent modification of carbon nanomaterials [3, 4]. Here, we present a simple, one-step method for functionalization of GQDs with gamma irradiation in the presence of amino acid L-cysteine as an S, N heteroatom donor and isopropyl alcohol as a radical scavenger. Water dispersion of GQDs with 1 vol% isopropyl alcohol and 2 mass% of L-cysteine was purged with Ar gas for 15 minutes and then exposed to gamma irradiation at doses: 25, 50 and 200 kGy. The optical and structural properties of obtained S, N-GQDs were investigated using Ultraviolet-visible spectroscopy (UV-Vis), Fourier-Transform Infrared spectroscopy (FTIR), Photoluminescence spectroscopy (PL), Atomic force microscopy (AFM) and Dynamic light scattering (DLS). Successful doping of S and N heteroatoms in the structure of irradiated GQDs was confirmed with FTIR analysis through detected S-H, C=S, and N-H stretching vibrations. Also, an improvement in photoluminescence quantum yield (QY) has been proved by PL measurements. The best result was achieved for the sample irradiated with a dose of 25 kGy. PL QY of this sample was 15 times higher compared to non-irradiated p-GQDs, and around 7 times higher up against other irradiated samples. Both AFM and DLS measurements were in correlation and indicated that gamma irradiation increased the layer separation and overall particle diameter of GQDs. The average diameter ranged from 25 nm up to around 30 nm for irradiated samples while the diameter of non-irradiated p-GQDs was 20 nm. The proposed one-step chemical doping provided an improvement in one of the most characteristic features of GQDs- photoluminescence, as well as in morphological properties. Due to this, the obtained S, N-GQDs have great potential for application in medicine as a bioimaging agent
PB  - Belgrade : Institute of Physics Belgrade
C3  - PHOTONICA2021 : 8th International School and Conference on Photonics and HEMMAGINERO workshop : Abstracts of Tutorial, Keynote, Invited Lectures, Progress Reports and Contributed Papers; August 23-27, 2021; Belgrade
T1  - Enhanced photoluminescence of gamma-irradiated S, N graphene quantum dots
SP  - 87
UR  - https://hdl.handle.net/21.15107/rcub_vinar_10907
ER  - 
@conference{
author = "Milenković, Mila and Kleut, Duška and Jovanović, Svetlana P.",
year = "2021",
abstract = "Zero-dimensional graphene quantum dots (GQDs) are one of the most promising luminescent carbonderived nanomaterials with different oxygen-containing functional groups on their surface. They consist of one or few layers of graphene and have a lateral dimension below 100 nm. Some of their distinct and superior physical and chemical properties such as tunable photoluminescence, good biocompatibility, low toxicity, and excellent dispersibility in water, make them a promising candidate for biomedical applications [1]. With the functionalization of GQDs, it is possible to modify their surface structure by adding other functional groups thus altering photoluminescence and enhancing their other properties [2]. Gamma irradiation proved to be a simple and eco-friendly method for subsequent modification of carbon nanomaterials [3, 4]. Here, we present a simple, one-step method for functionalization of GQDs with gamma irradiation in the presence of amino acid L-cysteine as an S, N heteroatom donor and isopropyl alcohol as a radical scavenger. Water dispersion of GQDs with 1 vol% isopropyl alcohol and 2 mass% of L-cysteine was purged with Ar gas for 15 minutes and then exposed to gamma irradiation at doses: 25, 50 and 200 kGy. The optical and structural properties of obtained S, N-GQDs were investigated using Ultraviolet-visible spectroscopy (UV-Vis), Fourier-Transform Infrared spectroscopy (FTIR), Photoluminescence spectroscopy (PL), Atomic force microscopy (AFM) and Dynamic light scattering (DLS). Successful doping of S and N heteroatoms in the structure of irradiated GQDs was confirmed with FTIR analysis through detected S-H, C=S, and N-H stretching vibrations. Also, an improvement in photoluminescence quantum yield (QY) has been proved by PL measurements. The best result was achieved for the sample irradiated with a dose of 25 kGy. PL QY of this sample was 15 times higher compared to non-irradiated p-GQDs, and around 7 times higher up against other irradiated samples. Both AFM and DLS measurements were in correlation and indicated that gamma irradiation increased the layer separation and overall particle diameter of GQDs. The average diameter ranged from 25 nm up to around 30 nm for irradiated samples while the diameter of non-irradiated p-GQDs was 20 nm. The proposed one-step chemical doping provided an improvement in one of the most characteristic features of GQDs- photoluminescence, as well as in morphological properties. Due to this, the obtained S, N-GQDs have great potential for application in medicine as a bioimaging agent",
publisher = "Belgrade : Institute of Physics Belgrade",
journal = "PHOTONICA2021 : 8th International School and Conference on Photonics and HEMMAGINERO workshop : Abstracts of Tutorial, Keynote, Invited Lectures, Progress Reports and Contributed Papers; August 23-27, 2021; Belgrade",
title = "Enhanced photoluminescence of gamma-irradiated S, N graphene quantum dots",
pages = "87",
url = "https://hdl.handle.net/21.15107/rcub_vinar_10907"
}
Milenković, M., Kleut, D.,& Jovanović, S. P.. (2021). Enhanced photoluminescence of gamma-irradiated S, N graphene quantum dots. in PHOTONICA2021 : 8th International School and Conference on Photonics and HEMMAGINERO workshop : Abstracts of Tutorial, Keynote, Invited Lectures, Progress Reports and Contributed Papers; August 23-27, 2021; Belgrade
Belgrade : Institute of Physics Belgrade., 87.
https://hdl.handle.net/21.15107/rcub_vinar_10907
Milenković M, Kleut D, Jovanović SP. Enhanced photoluminescence of gamma-irradiated S, N graphene quantum dots. in PHOTONICA2021 : 8th International School and Conference on Photonics and HEMMAGINERO workshop : Abstracts of Tutorial, Keynote, Invited Lectures, Progress Reports and Contributed Papers; August 23-27, 2021; Belgrade. 2021;:87.
https://hdl.handle.net/21.15107/rcub_vinar_10907 .
Milenković, Mila, Kleut, Duška, Jovanović, Svetlana P., "Enhanced photoluminescence of gamma-irradiated S, N graphene quantum dots" in PHOTONICA2021 : 8th International School and Conference on Photonics and HEMMAGINERO workshop : Abstracts of Tutorial, Keynote, Invited Lectures, Progress Reports and Contributed Papers; August 23-27, 2021; Belgrade (2021):87,
https://hdl.handle.net/21.15107/rcub_vinar_10907 .

Environmentally Friendly Method for S, N Functionalization of Graphene Quantum Dots

Milenković, Mila; Mišović, Aleksandra; Jovanović, Svetlana

(Szeged : University of Szeged, 2021)

TY  - CONF
AU  - Milenković, Mila
AU  - Mišović, Aleksandra
AU  - Jovanović, Svetlana
PY  - 2021
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/11424
AB  - Graphene quantum dots (GQDs) show exceptional optical and physical properties. To enable their wider application and improve their optical properties, it is usually necessary to modify them with different functional groups and heteroatoms. Toxic reagents that are potentially harmful to human health and the environment are often used for these procedures. One of the methods that have been successfully used is gamma radiation. In this study, gamma irradiation was employed to achieve structural modification of GQDs without the usage of reactive, toxic chemicals. In this way, an eco-friendly and simple procedure for the incorporation of S and N atoms into the GQDs structure is developed.
PB  - Szeged : University of Szeged
C3  - 27th International Symposium on Analytical and Environmental Problems : Proceedings; November 22-23, 2021; Szeged, Hungary
T1  - Environmentally Friendly Method for S, N Functionalization of Graphene Quantum Dots
SP  - 214
EP  - 217
UR  - https://hdl.handle.net/21.15107/rcub_vinar_11424
ER  - 
@conference{
author = "Milenković, Mila and Mišović, Aleksandra and Jovanović, Svetlana",
year = "2021",
abstract = "Graphene quantum dots (GQDs) show exceptional optical and physical properties. To enable their wider application and improve their optical properties, it is usually necessary to modify them with different functional groups and heteroatoms. Toxic reagents that are potentially harmful to human health and the environment are often used for these procedures. One of the methods that have been successfully used is gamma radiation. In this study, gamma irradiation was employed to achieve structural modification of GQDs without the usage of reactive, toxic chemicals. In this way, an eco-friendly and simple procedure for the incorporation of S and N atoms into the GQDs structure is developed.",
publisher = "Szeged : University of Szeged",
journal = "27th International Symposium on Analytical and Environmental Problems : Proceedings; November 22-23, 2021; Szeged, Hungary",
title = "Environmentally Friendly Method for S, N Functionalization of Graphene Quantum Dots",
pages = "214-217",
url = "https://hdl.handle.net/21.15107/rcub_vinar_11424"
}
Milenković, M., Mišović, A.,& Jovanović, S.. (2021). Environmentally Friendly Method for S, N Functionalization of Graphene Quantum Dots. in 27th International Symposium on Analytical and Environmental Problems : Proceedings; November 22-23, 2021; Szeged, Hungary
Szeged : University of Szeged., 214-217.
https://hdl.handle.net/21.15107/rcub_vinar_11424
Milenković M, Mišović A, Jovanović S. Environmentally Friendly Method for S, N Functionalization of Graphene Quantum Dots. in 27th International Symposium on Analytical and Environmental Problems : Proceedings; November 22-23, 2021; Szeged, Hungary. 2021;:214-217.
https://hdl.handle.net/21.15107/rcub_vinar_11424 .
Milenković, Mila, Mišović, Aleksandra, Jovanović, Svetlana, "Environmentally Friendly Method for S, N Functionalization of Graphene Quantum Dots" in 27th International Symposium on Analytical and Environmental Problems : Proceedings; November 22-23, 2021; Szeged, Hungary (2021):214-217,
https://hdl.handle.net/21.15107/rcub_vinar_11424 .