TY  - CONF
AU  - Ignjatović, Nenad L.
AU  - Ajduković, Zorica
AU  - Drmanić, S.
AU  - Uskoković, Dragan
PY  - 2011
UR  - http://dais.sanu.ac.rs/123456789/679
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/7507
AB  - Multifunctional drug delivery system based on hydroxyapatite may be a research challenge in the treatment and reconstruction of bone tissue. Vitamin D3 has a positive effect on osteogenesis as it increases osteoblast differentiation and mineralization of bone tissue. The purpose of the study presented in this paper has been to examine the possibility of the synthesis of a new multifunctional nanoparticulate system for local delivery of vitamin D3 suitable for applications in bone engineering. The synthesis, characterization and application of three nano particle systems was shown: hydroxyapatite, hydroxyapatite/vitamin D3 and hydroxyapatite/PLGA/vitamin D3. The obtained vitamin D3-loaded nanoparticles based on hydroxyapatite. Characterization was performed with wide-angle X-ray structural analysis (XRD), infrared spectroscopy (FT-IR), field-emission scanning electron microscopy (FESEM), zeta potential (ZP) and particle sized distribution (PSD) methods. Basic in vitro studies were performed implantation of materials in rats. XRD and FT-IR analyses confirmed that the vitamin D3 is loaded hydroxyapatite and PLGA. Different values of zeta potential may refer to different phenomenological processes during in vivo studies.
PB  - Belgrade : Materials Research Society of Serbia
C3  - The Thirteenth Annual Conference YUCOMAT 2011: Programme and the Book of Abstracts
T1  - Multifunctional nano particulate systems based on hydroxyapatite as systems for local delivery of vitamin D3
SP  - 68
EP  - 68
UR  - https://hdl.handle.net/21.15107/rcub_vinar_7507
ER  - 

@conference{
author = "Ignjatović, Nenad L. and Ajduković, Zorica and Drmanić, S. and Uskoković, Dragan",
year = "2011",
abstract = "Multifunctional drug delivery system based on hydroxyapatite may be a research challenge in the treatment and reconstruction of bone tissue. Vitamin D3 has a positive effect on osteogenesis as it increases osteoblast differentiation and mineralization of bone tissue. The purpose of the study presented in this paper has been to examine the possibility of the synthesis of a new multifunctional nanoparticulate system for local delivery of vitamin D3 suitable for applications in bone engineering. The synthesis, characterization and application of three nano particle systems was shown: hydroxyapatite, hydroxyapatite/vitamin D3 and hydroxyapatite/PLGA/vitamin D3. The obtained vitamin D3-loaded nanoparticles based on hydroxyapatite. Characterization was performed with wide-angle X-ray structural analysis (XRD), infrared spectroscopy (FT-IR), field-emission scanning electron microscopy (FESEM), zeta potential (ZP) and particle sized distribution (PSD) methods. Basic in vitro studies were performed implantation of materials in rats. XRD and FT-IR analyses confirmed that the vitamin D3 is loaded hydroxyapatite and PLGA. Different values of zeta potential may refer to different phenomenological processes during in vivo studies.",
publisher = "Belgrade : Materials Research Society of Serbia",
journal = "The Thirteenth Annual Conference YUCOMAT 2011: Programme and the Book of Abstracts",
title = "Multifunctional nano particulate systems based on hydroxyapatite as systems for local delivery of vitamin D3",
pages = "68-68",
url = "https://hdl.handle.net/21.15107/rcub_vinar_7507"
}

Ignjatović, N. L., Ajduković, Z., Drmanić, S.,& Uskoković, D.. (2011). Multifunctional nano particulate systems based on hydroxyapatite as systems for local delivery of vitamin D3. in The Thirteenth Annual Conference YUCOMAT 2011: Programme and the Book of Abstracts
Belgrade : Materials Research Society of Serbia., 68-68.
https://hdl.handle.net/21.15107/rcub_vinar_7507

Ignjatović NL, Ajduković Z, Drmanić S, Uskoković D. Multifunctional nano particulate systems based on hydroxyapatite as systems for local delivery of vitamin D3. in The Thirteenth Annual Conference YUCOMAT 2011: Programme and the Book of Abstracts. 2011;:68-68.
https://hdl.handle.net/21.15107/rcub_vinar_7507 .

Ignjatović, Nenad L., Ajduković, Zorica, Drmanić, S., Uskoković, Dragan, "Multifunctional nano particulate systems based on hydroxyapatite as systems for local delivery of vitamin D3" in The Thirteenth Annual Conference YUCOMAT 2011: Programme and the Book of Abstracts (2011):68-68,
https://hdl.handle.net/21.15107/rcub_vinar_7507 .