Multifunctional nano particulate systems based on hydroxyapatite as systems for local delivery of vitamin D3
2011
Преузимање 🢃
Аутори
Ignjatović, Nenad L.Ajduković, Zorica
Drmanić, S.
Uskoković, Dragan
Остала ауторства
Uskoković, DraganКонференцијски прилог
Метаподаци
Приказ свих података о документуАпстракт
Multifunctional drug delivery system based on hydroxyapatite may be a research challenge in the treatment and reconstruction of bone tissue. Vitamin D3 has a positive effect on osteogenesis as it increases osteoblast differentiation and mineralization of bone tissue. The purpose of the study presented in this paper has been to examine the possibility of the synthesis of a new multifunctional nanoparticulate system for local delivery of vitamin D3 suitable for applications in bone engineering. The synthesis, characterization and application of three nano particle systems was shown: hydroxyapatite, hydroxyapatite/vitamin D3 and hydroxyapatite/PLGA/vitamin D3. The obtained vitamin D3-loaded nanoparticles based on hydroxyapatite. Characterization was performed with wide-angle X-ray structural analysis (XRD), infrared spectroscopy (FT-IR), field-emission scanning electron microscopy (FESEM), zeta potential (ZP) and particle sized distribution (PSD) methods. Basic in vitro studies were perfo...rmed implantation of materials in rats. XRD and FT-IR analyses confirmed that the vitamin D3 is loaded hydroxyapatite and PLGA. Different values of zeta potential may refer to different phenomenological processes during in vivo studies.
Кључне речи:
hydroxyapatite / vitamin D / controlled delivery / nanoparticles / osteogenesisИзвор:
YUCOMAT 2011 : 13th Annual Conference YUCOMAT 2011: Programme and the Book of Abstracts, 2011, 68-68Издавач:
- Belgrade : Materials Research Society of Serbia
Финансирање / пројекти:
- Молекуларно дизајнирање наночестица контролисаних морфолошких и физичко-хемијских карактеристика и функционалних материјала на њиховој основи (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-45004)
Колекције
Институција/група
VinčaTY - CONF AU - Ignjatović, Nenad L. AU - Ajduković, Zorica AU - Drmanić, S. AU - Uskoković, Dragan PY - 2011 UR - http://dais.sanu.ac.rs/123456789/679 UR - https://vinar.vin.bg.ac.rs/handle/123456789/7507 AB - Multifunctional drug delivery system based on hydroxyapatite may be a research challenge in the treatment and reconstruction of bone tissue. Vitamin D3 has a positive effect on osteogenesis as it increases osteoblast differentiation and mineralization of bone tissue. The purpose of the study presented in this paper has been to examine the possibility of the synthesis of a new multifunctional nanoparticulate system for local delivery of vitamin D3 suitable for applications in bone engineering. The synthesis, characterization and application of three nano particle systems was shown: hydroxyapatite, hydroxyapatite/vitamin D3 and hydroxyapatite/PLGA/vitamin D3. The obtained vitamin D3-loaded nanoparticles based on hydroxyapatite. Characterization was performed with wide-angle X-ray structural analysis (XRD), infrared spectroscopy (FT-IR), field-emission scanning electron microscopy (FESEM), zeta potential (ZP) and particle sized distribution (PSD) methods. Basic in vitro studies were performed implantation of materials in rats. XRD and FT-IR analyses confirmed that the vitamin D3 is loaded hydroxyapatite and PLGA. Different values of zeta potential may refer to different phenomenological processes during in vivo studies. PB - Belgrade : Materials Research Society of Serbia C3 - YUCOMAT 2011 : 13th Annual Conference YUCOMAT 2011: Programme and the Book of Abstracts T1 - Multifunctional nano particulate systems based on hydroxyapatite as systems for local delivery of vitamin D3 SP - 68 EP - 68 UR - https://hdl.handle.net/21.15107/rcub_vinar_7507 ER -
@conference{ author = "Ignjatović, Nenad L. and Ajduković, Zorica and Drmanić, S. and Uskoković, Dragan", year = "2011", abstract = "Multifunctional drug delivery system based on hydroxyapatite may be a research challenge in the treatment and reconstruction of bone tissue. Vitamin D3 has a positive effect on osteogenesis as it increases osteoblast differentiation and mineralization of bone tissue. The purpose of the study presented in this paper has been to examine the possibility of the synthesis of a new multifunctional nanoparticulate system for local delivery of vitamin D3 suitable for applications in bone engineering. The synthesis, characterization and application of three nano particle systems was shown: hydroxyapatite, hydroxyapatite/vitamin D3 and hydroxyapatite/PLGA/vitamin D3. The obtained vitamin D3-loaded nanoparticles based on hydroxyapatite. Characterization was performed with wide-angle X-ray structural analysis (XRD), infrared spectroscopy (FT-IR), field-emission scanning electron microscopy (FESEM), zeta potential (ZP) and particle sized distribution (PSD) methods. Basic in vitro studies were performed implantation of materials in rats. XRD and FT-IR analyses confirmed that the vitamin D3 is loaded hydroxyapatite and PLGA. Different values of zeta potential may refer to different phenomenological processes during in vivo studies.", publisher = "Belgrade : Materials Research Society of Serbia", journal = "YUCOMAT 2011 : 13th Annual Conference YUCOMAT 2011: Programme and the Book of Abstracts", title = "Multifunctional nano particulate systems based on hydroxyapatite as systems for local delivery of vitamin D3", pages = "68-68", url = "https://hdl.handle.net/21.15107/rcub_vinar_7507" }
Ignjatović, N. L., Ajduković, Z., Drmanić, S.,& Uskoković, D.. (2011). Multifunctional nano particulate systems based on hydroxyapatite as systems for local delivery of vitamin D3. in YUCOMAT 2011 : 13th Annual Conference YUCOMAT 2011: Programme and the Book of Abstracts Belgrade : Materials Research Society of Serbia., 68-68. https://hdl.handle.net/21.15107/rcub_vinar_7507
Ignjatović NL, Ajduković Z, Drmanić S, Uskoković D. Multifunctional nano particulate systems based on hydroxyapatite as systems for local delivery of vitamin D3. in YUCOMAT 2011 : 13th Annual Conference YUCOMAT 2011: Programme and the Book of Abstracts. 2011;:68-68. https://hdl.handle.net/21.15107/rcub_vinar_7507 .
Ignjatović, Nenad L., Ajduković, Zorica, Drmanić, S., Uskoković, Dragan, "Multifunctional nano particulate systems based on hydroxyapatite as systems for local delivery of vitamin D3" in YUCOMAT 2011 : 13th Annual Conference YUCOMAT 2011: Programme and the Book of Abstracts (2011):68-68, https://hdl.handle.net/21.15107/rcub_vinar_7507 .