TY  - CONF
AU  - Marković, Vladimir
AU  - Jelić, Smiljana
AU  - Vukojević, Vesna
AU  - Kolar-Anić, Ljiljana
PY  - 2010
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9294
AB  - Glucocorticoids, the end products of the Hypothalamic-Pituitary-Adrenal (HPA)
axis, are widely used as anti-inflammatory and immunosuppressive drugs.
However, the feed-back effects of externally induced glucocorticoids on the HPA
axis activity remain widely unknown. In this study, we use numerical simulations
to investigate changes in the HPA axis activity caused by externally introduced
cortisol. We emulate the basal HPA activity using a stoichiometric model of the
HPA axis, and perturb its dynamics by abruptly changing cortisol levels during the
course of numerical integration, thereby mimicking cortisol increase under
treatment. Our study shows that the HPA axis activity is susceptible to
perturbations by cortisol and that external cortisol pulses elicit different responses,
depending on the dose and the time of cortisol introduction.
PB  - Society of Physical Chemists of Serbia
C3  - Physical chemistry 2010 : 10th international conference on fundamental and applied aspects of physical chemistry
T1  - Modelling the hypothalamic-pituitaryadrenal (hpa) axis response to external perturbations with cortisol
UR  - https://hdl.handle.net/21.15107/rcub_vinar_9294
ER  - 

@conference{
author = "Marković, Vladimir and Jelić, Smiljana and Vukojević, Vesna and Kolar-Anić, Ljiljana",
year = "2010",
abstract = "Glucocorticoids, the end products of the Hypothalamic-Pituitary-Adrenal (HPA)
axis, are widely used as anti-inflammatory and immunosuppressive drugs.
However, the feed-back effects of externally induced glucocorticoids on the HPA
axis activity remain widely unknown. In this study, we use numerical simulations
to investigate changes in the HPA axis activity caused by externally introduced
cortisol. We emulate the basal HPA activity using a stoichiometric model of the
HPA axis, and perturb its dynamics by abruptly changing cortisol levels during the
course of numerical integration, thereby mimicking cortisol increase under
treatment. Our study shows that the HPA axis activity is susceptible to
perturbations by cortisol and that external cortisol pulses elicit different responses,
depending on the dose and the time of cortisol introduction.",
publisher = "Society of Physical Chemists of Serbia",
journal = "Physical chemistry 2010 : 10th international conference on fundamental and applied aspects of physical chemistry",
title = "Modelling the hypothalamic-pituitaryadrenal (hpa) axis response to external perturbations with cortisol",
url = "https://hdl.handle.net/21.15107/rcub_vinar_9294"
}

Marković, V., Jelić, S., Vukojević, V.,& Kolar-Anić, L.. (2010). Modelling the hypothalamic-pituitaryadrenal (hpa) axis response to external perturbations with cortisol. in Physical chemistry 2010 : 10th international conference on fundamental and applied aspects of physical chemistry
Society of Physical Chemists of Serbia..
https://hdl.handle.net/21.15107/rcub_vinar_9294

Marković V, Jelić S, Vukojević V, Kolar-Anić L. Modelling the hypothalamic-pituitaryadrenal (hpa) axis response to external perturbations with cortisol. in Physical chemistry 2010 : 10th international conference on fundamental and applied aspects of physical chemistry. 2010;.
https://hdl.handle.net/21.15107/rcub_vinar_9294 .

Marković, Vladimir, Jelić, Smiljana, Vukojević, Vesna, Kolar-Anić, Ljiljana, "Modelling the hypothalamic-pituitaryadrenal (hpa) axis response to external perturbations with cortisol" in Physical chemistry 2010 : 10th international conference on fundamental and applied aspects of physical chemistry (2010),
https://hdl.handle.net/21.15107/rcub_vinar_9294 .