Modelling the hypothalamic-pituitaryadrenal (hpa) axis response to external perturbations with cortisol
Конференцијски прилог (Објављена верзија)
,
Society of Physical Chemists of Serbia
Метаподаци
Приказ свих података о документуАпстракт
Glucocorticoids, the end products of the Hypothalamic-Pituitary-Adrenal (HPA)
axis, are widely used as anti-inflammatory and immunosuppressive drugs.
However, the feed-back effects of externally induced glucocorticoids on the HPA
axis activity remain widely unknown. In this study, we use numerical simulations
to investigate changes in the HPA axis activity caused by externally introduced
cortisol. We emulate the basal HPA activity using a stoichiometric model of the
HPA axis, and perturb its dynamics by abruptly changing cortisol levels during the
course of numerical integration, thereby mimicking cortisol increase under
treatment. Our study shows that the HPA axis activity is susceptible to
perturbations by cortisol and that external cortisol pulses elicit different responses,
depending on the dose and the time of cortisol introduction.
Извор:
Physical chemistry 2010 : 10th international conference on fundamental and applied aspects of physical chemistry, 2010Издавач:
- Society of Physical Chemists of Serbia
Финансирање / пројекти:
- Физичка хемија динамичких стања и структура неравнотежних система - од монотоне до осцилаторне еволуције и хаоса (RS-MESTD-MPN2006-2010-142025)
Колекције
Институција/група
VinčaTY - CONF AU - Marković, Vladimir AU - Jelić, Smiljana AU - Vukojević, Vesna AU - Kolar-Anić, Ljiljana PY - 2010 UR - https://vinar.vin.bg.ac.rs/handle/123456789/9294 AB - Glucocorticoids, the end products of the Hypothalamic-Pituitary-Adrenal (HPA) axis, are widely used as anti-inflammatory and immunosuppressive drugs. However, the feed-back effects of externally induced glucocorticoids on the HPA axis activity remain widely unknown. In this study, we use numerical simulations to investigate changes in the HPA axis activity caused by externally introduced cortisol. We emulate the basal HPA activity using a stoichiometric model of the HPA axis, and perturb its dynamics by abruptly changing cortisol levels during the course of numerical integration, thereby mimicking cortisol increase under treatment. Our study shows that the HPA axis activity is susceptible to perturbations by cortisol and that external cortisol pulses elicit different responses, depending on the dose and the time of cortisol introduction. PB - Society of Physical Chemists of Serbia C3 - Physical chemistry 2010 : 10th international conference on fundamental and applied aspects of physical chemistry T1 - Modelling the hypothalamic-pituitaryadrenal (hpa) axis response to external perturbations with cortisol UR - https://hdl.handle.net/21.15107/rcub_vinar_9294 ER -
@conference{ author = "Marković, Vladimir and Jelić, Smiljana and Vukojević, Vesna and Kolar-Anić, Ljiljana", year = "2010", abstract = "Glucocorticoids, the end products of the Hypothalamic-Pituitary-Adrenal (HPA) axis, are widely used as anti-inflammatory and immunosuppressive drugs. However, the feed-back effects of externally induced glucocorticoids on the HPA axis activity remain widely unknown. In this study, we use numerical simulations to investigate changes in the HPA axis activity caused by externally introduced cortisol. We emulate the basal HPA activity using a stoichiometric model of the HPA axis, and perturb its dynamics by abruptly changing cortisol levels during the course of numerical integration, thereby mimicking cortisol increase under treatment. Our study shows that the HPA axis activity is susceptible to perturbations by cortisol and that external cortisol pulses elicit different responses, depending on the dose and the time of cortisol introduction.", publisher = "Society of Physical Chemists of Serbia", journal = "Physical chemistry 2010 : 10th international conference on fundamental and applied aspects of physical chemistry", title = "Modelling the hypothalamic-pituitaryadrenal (hpa) axis response to external perturbations with cortisol", url = "https://hdl.handle.net/21.15107/rcub_vinar_9294" }
Marković, V., Jelić, S., Vukojević, V.,& Kolar-Anić, L.. (2010). Modelling the hypothalamic-pituitaryadrenal (hpa) axis response to external perturbations with cortisol. in Physical chemistry 2010 : 10th international conference on fundamental and applied aspects of physical chemistry Society of Physical Chemists of Serbia.. https://hdl.handle.net/21.15107/rcub_vinar_9294
Marković V, Jelić S, Vukojević V, Kolar-Anić L. Modelling the hypothalamic-pituitaryadrenal (hpa) axis response to external perturbations with cortisol. in Physical chemistry 2010 : 10th international conference on fundamental and applied aspects of physical chemistry. 2010;. https://hdl.handle.net/21.15107/rcub_vinar_9294 .
Marković, Vladimir, Jelić, Smiljana, Vukojević, Vesna, Kolar-Anić, Ljiljana, "Modelling the hypothalamic-pituitaryadrenal (hpa) axis response to external perturbations with cortisol" in Physical chemistry 2010 : 10th international conference on fundamental and applied aspects of physical chemistry (2010), https://hdl.handle.net/21.15107/rcub_vinar_9294 .