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Chronic Latent Magnesium Deficiency in Obesity Decreases Positive Effects of Vitamin D on Cardiometabolic Risk Indicators
dc.creator | Stokić, Edita | |
dc.creator | Romani, Andrea | |
dc.creator | Ilinčić, Branislava | |
dc.creator | Kupusinac, Aleksandar | |
dc.creator | Stošić, Zoran | |
dc.creator | Isenović, Esma R. | |
dc.date.accessioned | 2018-11-23T08:42:28Z | |
dc.date.available | 2018-11-23T08:42:28Z | |
dc.date.issued | 2018 | |
dc.identifier.issn | 1570-1611 | |
dc.identifier.issn | 1875-6212 | |
dc.identifier.uri | http://www.eurekaselect.com/155079/article | |
dc.identifier.uri | https://vinar.vin.bg.ac.rs/handle/123456789/7951 | |
dc.description.abstract | Background: Obesity and micronutrient deficiencies contribute to the risk of cardiometabolic diseases such are type 2 diabetes mellitus and Cardiovascular Disease (CVD). Objective: We examined the frequency of concomitant deficit of Magnesium (Mg) and vitamin D in obese patients and evaluated the connection of these combined deficiencies with indicators of cardiometabolic risk in non-diabetic subjects. Methods: Non-diabetic middle aged adults (n = 80; mean age 36 +/- 4 years, 52% women) were recruited based on weight/adiposity parameters {[}i.e. Body Mass Index (BMI) and body fat percentage (FAT%)]. Cardiometabolic risk indicators {[}insulin resistance (Homeostatic Model Assessment for Insulin Resistance (HOMA-IR)) and CVD risk (Framingham risk score for predicting 10-year CVD)], Mg status (i.e. total serum Mg concentration (TMg), Chronic Latent Mg Deficiency (CLMD) -0.75-0.85 mmol/L), vitamin D status (i.e. serum concentration of 25-hydroxyvitamin D (25(OH) D), vitamin D deficiency < 50 nmol/l) were assessed. Results: Among obese subjects 36% presented a combination of vitamin D deficiency and CLMD. In all studied patients, 25(OH) D and TMg levels both, individually and combined, showed a negative linear correlation with HOMA-IR and CVD risk. In subjects with CLMD (TMg < 0.85 mmol/L), a negative linear coefficient was found between 25(OH) D and, HOMA-IR and CVD risk, compared with subjects with normal TMg status (TMg >= 0.85 mmol/L). Conclusion: CLMD and vitamin D deficiency may commonly be present in obese non-diabetic subjects. Individually and combined, both deficiencies predispose non-diabetic patients to increased risk of cardiometabolic diseases. Maintaining normal Mg status may improve the beneficial effects of vitamin D on cardiometabolic risk indicators. | en |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173033/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/174026/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/44006/RS// | |
dc.relation | Provincial Secretariat for Science and Technological Development of the Autonomous Province of Vojvodina (114-451-2856/2016) | |
dc.rights | restrictedAccess | |
dc.source | Current Vascular Pharmacology | |
dc.subject | Obesity | en |
dc.subject | micronutrients | en |
dc.subject | chronic latent magnesium deficiency | en |
dc.subject | vitamin D deficiency | en |
dc.subject | cardiometabolic risk indicators | en |
dc.subject | insulin resistance | en |
dc.title | Chronic Latent Magnesium Deficiency in Obesity Decreases Positive Effects of Vitamin D on Cardiometabolic Risk Indicators | en |
dc.type | article | en |
dc.rights.license | ARR | |
dcterms.abstract | Романи, Aндреа; Стокић, Едита; Илинчић, Бранислава; Купусинац, Aлександар; Стошић, Зоран; Исеновић, Есма Р.; | |
dc.rights.holder | © 2018 Bentham Science Publishers | |
dc.citation.volume | 16 | |
dc.citation.issue | 6 | |
dc.citation.spage | 610 | |
dc.citation.epage | 617 | |
dc.identifier.wos | 000444234200012 | |
dc.identifier.doi | 10.2174/1570161115666170821154841 | |
dc.citation.rank | M22 | |
dc.identifier.pmid | 28828979 | |
dc.type.version | publishedVersion | |
dc.identifier.scopus | 2-s2.0-85039731695 |
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