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Erythrocytotoxicity of tiazofurin in vivo and in vitro detected by scanning probe microscopy
(Toxicology Letters, 2004)
Tiazofurin (TZF) is a cytostatic drug that leads to depletion of the GTP pool in tumor and normal cells via its active metabolite tiazofurin-adenine dinucleotide (TAD). TAD was detected in different cell lines, but not in ...
Hematological toxicity associated with tiazofurin-influence on erythropoiesis
(Toxicology Letters, 2000)
In this study hematological toxicity was analyzed after the single and repeated applications of tiazofurin (TZF). Cellularity of bone marrow, spleen and peripheral blood was examined, spanning the period of fifty days after ...