Hematological toxicity associated with tiazofurin-influence on erythropoiesis
Само за регистроване кориснике
2000
Чланак у часопису (Објављена верзија)
,
(C) 2000 Elsevier Science Ireland Ltd
Метаподаци
Приказ свих података о документуАпстракт
In this study hematological toxicity was analyzed after the single and repeated applications of tiazofurin (TZF). Cellularity of bone marrow, spleen and peripheral blood was examined, spanning the period of fifty days after the initial application. Analysis of hematological parameters was performed by slightly modified conventional techniques. The fraction of erythroid series was monitored during the experiment. Presented data describe kinetics of damage and recovery of hemopoietic tissue. Our results indicate that the effect of tiazofurin on cellularity of bone marrow and spleen and on erythropoiesis is reversible and dose dependent within tested dose range and therapeutic regimes. Twenty days after the application normal function of hemopoietic tissues was restored. This approach and results can be useful in defining the timing for sequencing and combination therapy with tiazofurin. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.
Кључне речи:
tiazofurin / hematological toxicity / erythropoiesis / cellularity of bone marrow and spleenИзвор:
Toxicology Letters, 2000, 114, 1-3, 81-90
DOI: 10.1016/S0378-4274(99)00269-6
ISSN: 0378-4274
PubMed: 10713472
WoS: 000086231200010
Scopus: 2-s2.0-0034599384
Колекције
Институција/група
VinčaTY - JOUR AU - Vranić, Vesna AU - Savovski, K AU - Dedović-Tanić, Nasta AU - Dimitrijević, Bogomir B. PY - 2000 UR - https://vinar.vin.bg.ac.rs/handle/123456789/2335 AB - In this study hematological toxicity was analyzed after the single and repeated applications of tiazofurin (TZF). Cellularity of bone marrow, spleen and peripheral blood was examined, spanning the period of fifty days after the initial application. Analysis of hematological parameters was performed by slightly modified conventional techniques. The fraction of erythroid series was monitored during the experiment. Presented data describe kinetics of damage and recovery of hemopoietic tissue. Our results indicate that the effect of tiazofurin on cellularity of bone marrow and spleen and on erythropoiesis is reversible and dose dependent within tested dose range and therapeutic regimes. Twenty days after the application normal function of hemopoietic tissues was restored. This approach and results can be useful in defining the timing for sequencing and combination therapy with tiazofurin. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved. T2 - Toxicology Letters T1 - Hematological toxicity associated with tiazofurin-influence on erythropoiesis VL - 114 IS - 1-3 SP - 81 EP - 90 DO - 10.1016/S0378-4274(99)00269-6 ER -
@article{ author = "Vranić, Vesna and Savovski, K and Dedović-Tanić, Nasta and Dimitrijević, Bogomir B.", year = "2000", abstract = "In this study hematological toxicity was analyzed after the single and repeated applications of tiazofurin (TZF). Cellularity of bone marrow, spleen and peripheral blood was examined, spanning the period of fifty days after the initial application. Analysis of hematological parameters was performed by slightly modified conventional techniques. The fraction of erythroid series was monitored during the experiment. Presented data describe kinetics of damage and recovery of hemopoietic tissue. Our results indicate that the effect of tiazofurin on cellularity of bone marrow and spleen and on erythropoiesis is reversible and dose dependent within tested dose range and therapeutic regimes. Twenty days after the application normal function of hemopoietic tissues was restored. This approach and results can be useful in defining the timing for sequencing and combination therapy with tiazofurin. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.", journal = "Toxicology Letters", title = "Hematological toxicity associated with tiazofurin-influence on erythropoiesis", volume = "114", number = "1-3", pages = "81-90", doi = "10.1016/S0378-4274(99)00269-6" }
Vranić, V., Savovski, K., Dedović-Tanić, N.,& Dimitrijević, B. B.. (2000). Hematological toxicity associated with tiazofurin-influence on erythropoiesis. in Toxicology Letters, 114(1-3), 81-90. https://doi.org/10.1016/S0378-4274(99)00269-6
Vranić V, Savovski K, Dedović-Tanić N, Dimitrijević BB. Hematological toxicity associated with tiazofurin-influence on erythropoiesis. in Toxicology Letters. 2000;114(1-3):81-90. doi:10.1016/S0378-4274(99)00269-6 .
Vranić, Vesna, Savovski, K, Dedović-Tanić, Nasta, Dimitrijević, Bogomir B., "Hematological toxicity associated with tiazofurin-influence on erythropoiesis" in Toxicology Letters, 114, no. 1-3 (2000):81-90, https://doi.org/10.1016/S0378-4274(99)00269-6 . .