Prikaz osnovnih podataka o dokumentu
Synthesis and biological evaluation of new pyrazole- and tetrazole-related C-nucleosides with modified sugar moieties
dc.creator | Popsavin, M | |
dc.creator | Torovic, L | |
dc.creator | Spaic, S | |
dc.creator | Stankov, S | |
dc.creator | Kapor, Agneš | |
dc.creator | Tomić, Zoran D. | |
dc.creator | Popsavin, V | |
dc.date.accessioned | 2018-03-01T19:04:02Z | |
dc.date.available | 2018-03-01T19:04:02Z | |
dc.date.issued | 2002 | |
dc.identifier.issn | 0040-4020 | |
dc.identifier.uri | https://vinar.vin.bg.ac.rs/handle/123456789/2494 | |
dc.description.abstract | 3(5)-Carboxamido-4-(beta-D-ribofuranosyl)pyrazoles bearing 2-benzamido (15) and 3-mesyloxy (29) isosteric groups, as well as the tetrazole C-nucleosides with 2-benzamido-2-deoxy-beta-D-ribofuranose (19) and 3-azido-3-deoxy-beta-D-xylofuranose (36) as sugar segments, have been synthesized starting from D-glucose, by utilizing the 2,5-anhydro-D-glucose ethylene acetal derivatives 1 and 20 as divergent intermediates. The C-nucleosides 15 and 36 were shown to be moderate inhibitors of the in vitro growth of both N2a and BHK 21 tumour cell lines, whereas 29 showed a selective, although not potent cytotoxic activity against N2a cells. Compound 29 also showed a moderate in vitro antiviral activity towards the rabies virus. (C) 2002 Elsevier Science Ltd. All rights reserved. | en |
dc.rights | restrictedAccess | en |
dc.source | Tetrahedron | en |
dc.subject | C-nucleosides | en |
dc.subject | pyrazoles | en |
dc.subject | tetrazoles | en |
dc.subject | cytotoxic activity | en |
dc.subject | antiviral activity | en |
dc.subject | 2,5-anhydro sugars | en |
dc.subject | X-ray crystallography | en |
dc.title | Synthesis and biological evaluation of new pyrazole- and tetrazole-related C-nucleosides with modified sugar moieties | en |
dc.type | article | en |
dcterms.abstract | Торовиц, Л; Спаиц, С; Станков, С; Капор, A; Попсавин, М; Томић Зоран; Попсавин, В; | |
dc.citation.volume | 58 | |
dc.citation.issue | 3 | |
dc.citation.spage | 569 | |
dc.citation.epage | 580 | |
dc.identifier.wos | 000173338300012 | |
dc.identifier.doi | 10.1016/S0040-4020(01)01126-7 | |
dc.citation.rank | M21 | |
dc.identifier.scopus | 2-s2.0-0037074195 |
Dokumenti
Datoteke | Veličina | Format | Pregled |
---|---|---|---|
Uz ovaj zapis nema datoteka. |