dc.creator | Marinkovic, V | |
dc.creator | Agbaba, Danica | |
dc.creator | Karljiković-Rajić, Katarina | |
dc.creator | Čomor, Jožef J. | |
dc.creator | Zivanov-Stakic, D | |
dc.date.accessioned | 2018-03-01T18:50:20Z | |
dc.date.available | 2018-03-01T18:50:20Z | |
dc.date.issued | 2000 | |
dc.identifier.issn | 0014-827X | |
dc.identifier.uri | https://vinar.vin.bg.ac.rs/handle/123456789/2337 | |
dc.description.abstract | The photodecomposition of nisoldipine ((+/-)3-isobutyl-5-methyl-1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-pyridine-3,5-dicarboxylate), whereby its 4-(2-nitrosophenyl) pyridine analogue is obtained as the photolytic product, was investigated under daylight exposure by means of UV derivative spectrophotometry. The optimal instrumental parameters (120 nm/min scan speed: 2 nm slit width; Delta lambda = 10 nm and 5 s response time) for analogue derivative spectra were established for amplitudes D-1(285) and D-2(291) (measured to the baseline) of the nitroso analogue assay, as well as for D-1(386) of the parent compound-nisoldipine assay. Using the first-order derivative spectrum, the minimum detectable amount of nitroso analogue in the presence of nisoldipine was equivalent to an impurity level of 5% and by the second-order derivative spectrum, the determination limit was equivalent to an impurity level of 2%. The degradation of nisoldipine followed within 30 days and the calculated maximal degradation rate was 1.6% per day for nisoldipine raw material, but significantly lower values of 0.19 and 0.15% per day were obtained for Nisoldin(R) tablets (10 and 5 mg, respectively). (C) 2000 Elsevier Science S.A. All rights reserved. | en |
dc.rights | restrictedAccess | en |
dc.source | Il Farmaco | en |
dc.subject | nisoldipine | en |
dc.subject | photodegradation | en |
dc.subject | derivative UV spectrophotometry | en |
dc.title | UV derivative spectrophotometric study of the photochemical degradation of nisoldipine | en |
dc.type | article | en |
dcterms.abstract | Цомор, Ј; Зиванов-Стакиц, Д; Маринковиц, В; Aгбаба, Д; Карљиковиц-Рајиц, К; | |
dc.citation.volume | 55 | |
dc.citation.issue | 2 | |
dc.citation.spage | 128 | |
dc.citation.epage | 133 | |
dc.identifier.wos | 000086306600009 | |
dc.identifier.doi | 10.1016/S0014-827X(00)00004-5 | |
dc.citation.rank | M23 | |
dc.identifier.pmid | 10782384 | |
dc.identifier.scopus | 2-s2.0-0034063177 | |