Technology for remote temparature measurements in microfluidic devices

Akronim / šifra: REMTES / 7017
NIO nosilac projekta: Univerzitet u Beogradu - Institut za nuklearne nauke „Vinča“
Rukovodilac projekta: Miroslav Dramićanin, naučni savetnik

Projekat finansira: Fond za nauku Republike Srbije
Program: PRIZMA
Period realizacije: 2023 - 2026.
Website: remtes-prizma.org

[sr] Senzori temperature čine oko 80% svetskog tržišta senzora, za koje se očekuje da će do 2028. godine vredeti 8 milijardi evra. Iako ima mnogo uređaja za merenje temperature, samo nekoliko termometara može da radi u savremenim okruženjima, kao što su biomedicina, mikro/nanofluidika, i opto/nanoelektronika, gde su potrebne prostorne rezolucije manje od 1 mm. Postoji do sada nedostignuta potreba za široko-primenljivom tehnikom za merenje temperatura u malim zapreminama fluida ( < 1 nL), gde tradicionalna termometrija nije prikladna ili čak moguća. Projeat će razviti optički samoreferentni termometar sa prostornom rezolucijom manjom od 1 mm razvijajući luminiscentnu termometriju. Dizajniraće se i proizvoditi nove probe (materijali) za luminescentnu termometriju koristeći najsavremenije neorganske luminescentne materijale koji emituju u crveno–duboko-crvenim–blisko infracrvenim spektralnim oblastima koji su veoma osetljivi na temperaturu. Unapređenjem očitavanja temperature putem luminiscencije, uspostaviće se potpuno nova tehnologija za daljinsko merenje i kontrolu temperature u mikrofluidnim uređajima na nivou tehnološke spremnosti 5 (TRL5). Kao dokaz koncepta od nauke do tehnologije, demonstriraće se visoko-osetljiv sistem mikrofluidne hemijske analize za kvantifikaciju analita i detekciju pojedinačnih nanočestica u toku fluida, baziran na fototermičkim efektima.

[en] Temperature sensors account for approximately 80% of the world sensor market, which is expected to be worth 8 billion EUR by 2028. Even though temperature measuring devices abound, only a few thermometers can operate in contemporary environments, such as biomedicine, micro/nanofluidics, and opto/nanoelectronics, where spatial resolutions of less than 1 μm are required. There is a current unmet need for a broadly applicable technique for measuring temperatures in small fluid volumes (< 1 nL), where traditional thermometry is not suitable or even possible. Here, we will develop an optical self-referencing thermometer with a spatial resolution of less than 1 μm by the targeted development of luminescence thermometry. We will design and fabricate novel luminescence thermometry probes using cutting-edge inorganic luminescent materials that emit in the red–deep-red–NIR spectral regions and are highly temperature sensitive. By advancing temperature readings from luminescence, we will establish a completely new technology for remote measuring and controlling temperature in microfluidic devices at the technology readiness level 5 (TRL5). As proof of the science-to-technology breakthrough, we will fabricate a showcase exemplar of a photothermally based highly sensitive microfluidic chemical analysis system for quantification of analytes and the detection of individual nanoparticles in a liquid flow.