In Israel, Vipera xantina palestinae (V.x.p.) is the most common venomous snake, accounting for several hundred cases of envenomation in humans and domestic animals every year, with a mortality rate of 0.5 to 2%. In this review we will briefly address the research developments relevant to our present understanding of the structure and function of V.x.p. venom with emphasis on venom disintegrins. Venom proteomics indicated the presence of four families of pharmacologically active compounds: (i) neurotoxins; (ii) hemorrhagins; (iii) angioneurin growth factors; and (iv) different types of integrin inhibitors. Viperistatin, a α1β1selective KTS disintegrin and VP12, a α2β1 selective C-type lectin were discovered. These snake venom proteins represent promising tools for research and development of novel collagen receptor selective drugs. These discoveries are also relevant for future improvement of antivenom therapy towards V.x.p. envenomation.
TY - JOUR
AU - Momić, Tatjana
AU - Arlinghaus, Franziska T.
AU - Arien-Zakay, Hadar
AU - Katzhendler, Jeoshua
AU - Eble, Johannes A.
AU - Marcinkiewicz, Cezary
AU - Lazarovici, Philip
PY - 2011
UR - https://vinar.vin.bg.ac.rs/handle/123456789/15394
AB - In Israel, Vipera xantina palestinae (V.x.p.) is the most common venomous snake, accounting for several hundred cases of envenomation in humans and domestic animals every year, with a mortality rate of 0.5 to 2%. In this review we will briefly address the research developments relevant to our present understanding of the structure and function of V.x.p. venom with emphasis on venom disintegrins. Venom proteomics indicated the presence of four families of pharmacologically active compounds: (i) neurotoxins; (ii) hemorrhagins; (iii) angioneurin growth factors; and (iv) different types of integrin inhibitors. Viperistatin, a α1β1selective KTS disintegrin and VP12, a α2β1 selective C-type lectin were discovered. These snake venom proteins represent promising tools for research and development of novel collagen receptor selective drugs. These discoveries are also relevant for future improvement of antivenom therapy towards V.x.p. envenomation.
T2 - Toxins
T1 - Pharmacological Aspects of Vipera xantina palestinae Venom
VL - 3
IS - 11
SP - 1420
EP - 1432
DO - 10.3390/toxins3111420
ER -
@article{
author = "Momić, Tatjana and Arlinghaus, Franziska T. and Arien-Zakay, Hadar and Katzhendler, Jeoshua and Eble, Johannes A. and Marcinkiewicz, Cezary and Lazarovici, Philip",
year = "2011",
abstract = "In Israel, Vipera xantina palestinae (V.x.p.) is the most common venomous snake, accounting for several hundred cases of envenomation in humans and domestic animals every year, with a mortality rate of 0.5 to 2%. In this review we will briefly address the research developments relevant to our present understanding of the structure and function of V.x.p. venom with emphasis on venom disintegrins. Venom proteomics indicated the presence of four families of pharmacologically active compounds: (i) neurotoxins; (ii) hemorrhagins; (iii) angioneurin growth factors; and (iv) different types of integrin inhibitors. Viperistatin, a α1β1selective KTS disintegrin and VP12, a α2β1 selective C-type lectin were discovered. These snake venom proteins represent promising tools for research and development of novel collagen receptor selective drugs. These discoveries are also relevant for future improvement of antivenom therapy towards V.x.p. envenomation.",
journal = "Toxins",
title = "Pharmacological Aspects of Vipera xantina palestinae Venom",
volume = "3",
number = "11",
pages = "1420-1432",
doi = "10.3390/toxins3111420"
}
Momić, T., Arlinghaus, F. T., Arien-Zakay, H., Katzhendler, J., Eble, J. A., Marcinkiewicz, C.,& Lazarovici, P.. (2011). Pharmacological Aspects of Vipera xantina palestinae Venom. in Toxins, 3(11), 1420-1432.
https://doi.org/10.3390/toxins3111420
Momić T, Arlinghaus FT, Arien-Zakay H, Katzhendler J, Eble JA, Marcinkiewicz C, Lazarovici P. Pharmacological Aspects of Vipera xantina palestinae Venom. in Toxins. 2011;3(11):1420-1432.
doi:10.3390/toxins3111420 .
Momić, Tatjana, Arlinghaus, Franziska T., Arien-Zakay, Hadar, Katzhendler, Jeoshua, Eble, Johannes A., Marcinkiewicz, Cezary, Lazarovici, Philip, "Pharmacological Aspects of Vipera xantina palestinae Venom" in Toxins, 3, no. 11 (2011):1420-1432,
https://doi.org/10.3390/toxins3111420 . .
