Design of RADIOactive MAGnetic nanoconstructs for tumour therapy by synergy of nanobrachytherapy and magnetic hyperthermia

Akronim / šifra: RadioMag / 7282
NIO nosilac projekta: Univerzitet u Beogradu - Institut za nuklearne nauke „Vinča“
Rukovodilac projekta: Sanja Vranješ Đurić
website: https://www.vincent.org.rs/en/project/radiomag-2024/

Projekat finansira: Fond za nauku Republike Srbije
Program: PRIZMA
Period realizacije: 2023 - 2026.

RadioMag Project’s aim is to introduce a unique combination of internal radiation therapy (nanobrachytherapy (NBT)) and heating, which relies on nanoconstructs labelled with therapeutic radionuclides. As generators of simultaneous (bi-modal) local nanobrachytherapy and local magnetic hyperthermia (MH), these nanoconstructs by new approaches are expected to boost cancer combat by synergism or a cumulative effect. RadioMag also addresses the design of new nanoconstructs based on multicore magnetic nanoparticles (MNPs) with flower-like morphology and single MNPs with different morphologies and high heating efficiency in MH therapy. The implementation plan concerns the synthesis of MNPs based on magnetite and maghemite and their coating with thin-layer organic compounds suitable for radiolabelling with therapeutic radionuclides (177Lu, 90Y, 131I). Samples analysis will be used to elucidate chemical, physical and biological underlying mechanisms at the nanoscale and to improve tailoring of the desired properties. The efficacy of the bi-modal therapy will be tested in vitro/in vivo on the CT-26 murine colon and 4T1 metastatic murine mammary carcinoma models. Besides scientific impact, the main anticipated Project outcome is the fabrication of radioactive nanoconstructs with improved therapeutic effect verified in preclinical testing, as the first step in the development of next-generation radiopharmaceuticals (magnetic nano radiopharmaceuticals) for application in bi-modal therapy.