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Monolacunary Wells-Dawson Polyoxometalate as a Novel Contrast Agent for Computed Tomography: A Comprehensive Study on In Vivo Toxicity and Biodistribution
dc.creator | Stojanović, Marko | |
dc.creator | Čolović, Mirjana B. | |
dc.creator | Lalatović, Jovana | |
dc.creator | Milosavljević, Aleksandra | |
dc.creator | Savić, Nada D. | |
dc.creator | Declerck, Kilian | |
dc.creator | Radosavljević, Branimir | |
dc.creator | Ćetković, Mila | |
dc.creator | Kravić-Stevović, Tamara | |
dc.creator | Parac-Vogt, Tatjana N. | |
dc.creator | Krstić, Danijela | |
dc.date.accessioned | 2024-02-23T11:18:25Z | |
dc.date.available | 2024-02-23T11:18:25Z | |
dc.date.issued | 2024 | |
dc.identifier.issn | 1422-0067 | |
dc.identifier.uri | https://vinar.vin.bg.ac.rs/handle/123456789/12867 | |
dc.description.abstract | Polyoxotungstate nanoclusters have recently emerged as promising contrast agents for computed tomography (CT). In order to evaluate their clinical potential, in this study, we evaluated the in vitro CT imaging properties, potential toxic effects in vivo, and tissue distribution of monolacunary Wells–Dawson polyoxometalate, α2-K10P2W17O61.20H2O (mono-WD POM). Mono-WD POM showed superior X-ray attenuation compared to other tungsten-containing nanoclusters (its parent WD-POM and Keggin POM) and the standard iodine-based contrast agent (iohexol). The calculated X-ray attenuation linear slope for mono-WD POM was significantly higher compared to parent WD-POM, Keggin POM, and iohexol (5.97 ± 0.14 vs. 4.84 ± 0.05, 4.55 ± 0.16, and 4.30 ± 0.09, respectively). Acute oral (maximum-administered dose (MAD) = 960 mg/kg) and intravenous administration (1/10, 1/5, and 1/3 MAD) of mono-WD POM did not induce unexpected changes in rats’ general habits or mortality. Results of blood gas analysis, CO-oximetry status, and the levels of electrolytes, glucose, lactate, creatinine, and BUN demonstrated a dose-dependent tendency 14 days after intravenous administration of mono-WD POM. The most significant differences compared to the control were observed for 1/3 MAD, being approximately seventy times higher than the typically used dose (0.015 mmol W/kg) of tungsten-based contrast agents. The highest tungsten deposition was found in the kidney (1/3 MAD—0.67 ± 0.12; 1/5 MAD—0.59 ± 0.07; 1/10 MAD—0.54 ± 0.05), which corresponded to detected morphological irregularities, electrolyte imbalance, and increased BUN levels. | en |
dc.language.iso | en | |
dc.relation | info:eu-repo/grantAgreement/MESTD/inst-2020/200110/RS// | en |
dc.relation | info:eu-repo/grantAgreement/MESTD/inst-2020/200017/RS// | en |
dc.relation | info:eu-repo/grantAgreement/ScienceFundRS/Dijaspora/6526393/RS// | en |
dc.relation | Serbian Academy of Sciences and Arts [Grant no. F-35] | en |
dc.relation | FWO [1267623N] | en |
dc.rights | openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.source | International Journal of Molecular Sciences | en |
dc.subject | blood gas analysis | en |
dc.subject | CO-oximetry status | en |
dc.subject | biochemical parameters | en |
dc.subject | histological analysis | en |
dc.subject | in vitro computed tomography imaging | en |
dc.subject | in vivo toxicity | en |
dc.subject | monolacunary Wells-Dawson polyoxotungstate | en |
dc.subject | tissue distribution | en |
dc.subject | X-ray attenuation | en |
dc.title | Monolacunary Wells-Dawson Polyoxometalate as a Novel Contrast Agent for Computed Tomography: A Comprehensive Study on In Vivo Toxicity and Biodistribution | en |
dc.type | article | en |
dc.rights.license | BY | |
dc.citation.volume | 25 | |
dc.citation.issue | 5 | |
dc.citation.spage | 2569 | |
dc.identifier.doi | 10.3390/ijms25052569 | |
dc.type.version | publishedVersion | |
dc.identifier.fulltext | http://vinar.vin.bg.ac.rs/bitstream/id/35530/ijms-25-02569-v2.pdf |
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