Tally-2.0: upgraded validator of tandem repeat detection in protein sequences
Само за регистроване кориснике
2020
Аутори
Perović, Vladimir R.Leclercq, Jeremy Y
Šumonja, Neven
Richard, Francois D
Veljković, Nevena V.
Kajava, Andrey V.
Чланак у часопису (Објављена верзија)
,
© 2020 The Author(s). Published by Oxford University Press.
Метаподаци
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Motivation: Proteins containing tandem repeats (TRs) are abundant, frequently fold in elongated non-globular structures and perform vital functions. A number of computational tools have been developed to detect TRs in protein sequences. A blurred boundary between imperfect TR motifs and non-repetitive sequences gave rise to necessity to validate the detected TRs. Results: Tally-2.0 is a scoring tool based on a machine learning (ML) approach, which allows to validate the results of TR detection. It was upgraded by using improved training datasets and additional ML features. Tally-2.0 performs at a level of 93% sensitivity, 83% specificity and an area under the receiver operating characteristic curve of 95%.
Извор:
Bioinformatics, 2020, 36, 10, 3260-3262Финансирање / пројекти:
- H2020-MSCA-RISE project REFRACT [GA No. 823886]
- National Institute of Allergy and Infectious Diseases [Research Grant 1R01AI12123701]
- Примена EIIP/ISM биоинформатичке платформе у откривању нових терапеутских таргета и потенцијалних терапеутских молекула (RS-MESTD-Basic Research (BR or ON)-173001)
DOI: 10.1093/bioinformatics/btaa121
ISSN: 1367-4803
PubMed: 32096820
WoS: 000537447900045
Scopus: 2-s2.0-85084695735
Институција/група
VinčaTY - JOUR AU - Perović, Vladimir R. AU - Leclercq, Jeremy Y AU - Šumonja, Neven AU - Richard, Francois D AU - Veljković, Nevena V. AU - Kajava, Andrey V. PY - 2020 UR - https://vinar.vin.bg.ac.rs/handle/123456789/8997 AB - Motivation: Proteins containing tandem repeats (TRs) are abundant, frequently fold in elongated non-globular structures and perform vital functions. A number of computational tools have been developed to detect TRs in protein sequences. A blurred boundary between imperfect TR motifs and non-repetitive sequences gave rise to necessity to validate the detected TRs. Results: Tally-2.0 is a scoring tool based on a machine learning (ML) approach, which allows to validate the results of TR detection. It was upgraded by using improved training datasets and additional ML features. Tally-2.0 performs at a level of 93% sensitivity, 83% specificity and an area under the receiver operating characteristic curve of 95%. T2 - Bioinformatics T1 - Tally-2.0: upgraded validator of tandem repeat detection in protein sequences VL - 36 IS - 10 SP - 3260 EP - 3262 DO - 10.1093/bioinformatics/btaa121 ER -
@article{ author = "Perović, Vladimir R. and Leclercq, Jeremy Y and Šumonja, Neven and Richard, Francois D and Veljković, Nevena V. and Kajava, Andrey V.", year = "2020", abstract = "Motivation: Proteins containing tandem repeats (TRs) are abundant, frequently fold in elongated non-globular structures and perform vital functions. A number of computational tools have been developed to detect TRs in protein sequences. A blurred boundary between imperfect TR motifs and non-repetitive sequences gave rise to necessity to validate the detected TRs. Results: Tally-2.0 is a scoring tool based on a machine learning (ML) approach, which allows to validate the results of TR detection. It was upgraded by using improved training datasets and additional ML features. Tally-2.0 performs at a level of 93% sensitivity, 83% specificity and an area under the receiver operating characteristic curve of 95%.", journal = "Bioinformatics", title = "Tally-2.0: upgraded validator of tandem repeat detection in protein sequences", volume = "36", number = "10", pages = "3260-3262", doi = "10.1093/bioinformatics/btaa121" }
Perović, V. R., Leclercq, J. Y., Šumonja, N., Richard, F. D., Veljković, N. V.,& Kajava, A. V.. (2020). Tally-2.0: upgraded validator of tandem repeat detection in protein sequences. in Bioinformatics, 36(10), 3260-3262. https://doi.org/10.1093/bioinformatics/btaa121
Perović VR, Leclercq JY, Šumonja N, Richard FD, Veljković NV, Kajava AV. Tally-2.0: upgraded validator of tandem repeat detection in protein sequences. in Bioinformatics. 2020;36(10):3260-3262. doi:10.1093/bioinformatics/btaa121 .
Perović, Vladimir R., Leclercq, Jeremy Y, Šumonja, Neven, Richard, Francois D, Veljković, Nevena V., Kajava, Andrey V., "Tally-2.0: upgraded validator of tandem repeat detection in protein sequences" in Bioinformatics, 36, no. 10 (2020):3260-3262, https://doi.org/10.1093/bioinformatics/btaa121 . .