Central and baroreflex control of heart rate during the wake-sleep cycle in rat
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2001
Authors
Zoccoli, GiovannaAndreoli, E
Bojić, Tijana
Cianci, Tullia
Franzini, Carlo
Predieri, Silvia
Lenzi, Pierluigi
Article (Published version)
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Spontaneous fluctuations in Heart Period (HP) and Mean Arterial Pressure (MAP) make it possible to evaluate baroreceptor-heart rate reflex sensitivity (BRS). 30-s sequences of HP and MAP beat-to-beat values were considered in the different wake-sleep states (Wake, W; Quiet Sleep, QS; Active Sleep, AS) in rats to assess whether 1) BRS changes between states and 2) the different indexes supply consistent BRS measures. BRS indexes were calculated according to validated literature procedures as regression coefficients of HP vs. MAP 1) within all ramps of increasing or decreasing MAP of four beats or more, with HP and MAP changing in the same direction (baroreflex-mediated fluctuations, BRSp), 2) within all such ramps irrespective of the relative direction of HP and MAP changes (baroreflex + non-baroreflex, i.e. non-homeostatic centrally driven, fluctuations, BRSA). HP vs. MAP regression coefficient along the entire 30-s sequence (bHPMAP) was also calculated. Results: BRSp did not change am...ong states, BRSA decreased from QS to W to AS, bHPMAP decreased from QS to W and became negative in AS. Conclusions: 1) as indicated by BRSp, baroreflex sensitivity is state independent, 2) BRSp to BRSA to bHPMAP are increasingly affected by non-baroreflex fluctuations, BRSp being most apt to measure BRS, 3) non-homeostatic MAP and HP fluctuations increase from QS to W and prevail in AS. These potentially harmful fluctuations are normally buffered by baroreflexes: in the case of baroreflex impairment, circulatory risk may arise in conditions like AS, when they prevail.
Keywords:
sleep / heart rate / baroreflex / circulationSource:
Sleep, 2001, 24, 7, 753-758
DOI: 10.1093/sleep/24.7.753
ISSN: 0161-8105
PubMed: 11683478
WoS: 000171712400003
Scopus: 2-s2.0-0035499132
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VinčaTY - JOUR AU - Zoccoli, Giovanna AU - Andreoli, E AU - Bojić, Tijana AU - Cianci, Tullia AU - Franzini, Carlo AU - Predieri, Silvia AU - Lenzi, Pierluigi PY - 2001 UR - https://vinar.vin.bg.ac.rs/handle/123456789/8877 AB - Spontaneous fluctuations in Heart Period (HP) and Mean Arterial Pressure (MAP) make it possible to evaluate baroreceptor-heart rate reflex sensitivity (BRS). 30-s sequences of HP and MAP beat-to-beat values were considered in the different wake-sleep states (Wake, W; Quiet Sleep, QS; Active Sleep, AS) in rats to assess whether 1) BRS changes between states and 2) the different indexes supply consistent BRS measures. BRS indexes were calculated according to validated literature procedures as regression coefficients of HP vs. MAP 1) within all ramps of increasing or decreasing MAP of four beats or more, with HP and MAP changing in the same direction (baroreflex-mediated fluctuations, BRSp), 2) within all such ramps irrespective of the relative direction of HP and MAP changes (baroreflex + non-baroreflex, i.e. non-homeostatic centrally driven, fluctuations, BRSA). HP vs. MAP regression coefficient along the entire 30-s sequence (bHPMAP) was also calculated. Results: BRSp did not change among states, BRSA decreased from QS to W to AS, bHPMAP decreased from QS to W and became negative in AS. Conclusions: 1) as indicated by BRSp, baroreflex sensitivity is state independent, 2) BRSp to BRSA to bHPMAP are increasingly affected by non-baroreflex fluctuations, BRSp being most apt to measure BRS, 3) non-homeostatic MAP and HP fluctuations increase from QS to W and prevail in AS. These potentially harmful fluctuations are normally buffered by baroreflexes: in the case of baroreflex impairment, circulatory risk may arise in conditions like AS, when they prevail. T2 - Sleep T1 - Central and baroreflex control of heart rate during the wake-sleep cycle in rat VL - 24 IS - 7 SP - 753 EP - 758 DO - 10.1093/sleep/24.7.753 ER -
@article{ author = "Zoccoli, Giovanna and Andreoli, E and Bojić, Tijana and Cianci, Tullia and Franzini, Carlo and Predieri, Silvia and Lenzi, Pierluigi", year = "2001", abstract = "Spontaneous fluctuations in Heart Period (HP) and Mean Arterial Pressure (MAP) make it possible to evaluate baroreceptor-heart rate reflex sensitivity (BRS). 30-s sequences of HP and MAP beat-to-beat values were considered in the different wake-sleep states (Wake, W; Quiet Sleep, QS; Active Sleep, AS) in rats to assess whether 1) BRS changes between states and 2) the different indexes supply consistent BRS measures. BRS indexes were calculated according to validated literature procedures as regression coefficients of HP vs. MAP 1) within all ramps of increasing or decreasing MAP of four beats or more, with HP and MAP changing in the same direction (baroreflex-mediated fluctuations, BRSp), 2) within all such ramps irrespective of the relative direction of HP and MAP changes (baroreflex + non-baroreflex, i.e. non-homeostatic centrally driven, fluctuations, BRSA). HP vs. MAP regression coefficient along the entire 30-s sequence (bHPMAP) was also calculated. Results: BRSp did not change among states, BRSA decreased from QS to W to AS, bHPMAP decreased from QS to W and became negative in AS. Conclusions: 1) as indicated by BRSp, baroreflex sensitivity is state independent, 2) BRSp to BRSA to bHPMAP are increasingly affected by non-baroreflex fluctuations, BRSp being most apt to measure BRS, 3) non-homeostatic MAP and HP fluctuations increase from QS to W and prevail in AS. These potentially harmful fluctuations are normally buffered by baroreflexes: in the case of baroreflex impairment, circulatory risk may arise in conditions like AS, when they prevail.", journal = "Sleep", title = "Central and baroreflex control of heart rate during the wake-sleep cycle in rat", volume = "24", number = "7", pages = "753-758", doi = "10.1093/sleep/24.7.753" }
Zoccoli, G., Andreoli, E., Bojić, T., Cianci, T., Franzini, C., Predieri, S.,& Lenzi, P.. (2001). Central and baroreflex control of heart rate during the wake-sleep cycle in rat. in Sleep, 24(7), 753-758. https://doi.org/10.1093/sleep/24.7.753
Zoccoli G, Andreoli E, Bojić T, Cianci T, Franzini C, Predieri S, Lenzi P. Central and baroreflex control of heart rate during the wake-sleep cycle in rat. in Sleep. 2001;24(7):753-758. doi:10.1093/sleep/24.7.753 .
Zoccoli, Giovanna, Andreoli, E, Bojić, Tijana, Cianci, Tullia, Franzini, Carlo, Predieri, Silvia, Lenzi, Pierluigi, "Central and baroreflex control of heart rate during the wake-sleep cycle in rat" in Sleep, 24, no. 7 (2001):753-758, https://doi.org/10.1093/sleep/24.7.753 . .