Sleep-Related Changes in the Regulation of Cerebral Blood Flow in Newborn Lambs
Аутори
Silvani, AlessandroBojić, Tijana
Franzini, Carlo
Lenzi, Pierluigi
Walker, Adrian M
Grant, Daniel A
Wild, Jennene
Zoccoli, Giovanna
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Study Objectives: The interplay between cerebral perfusion pressure (CPP) and vascular resistance leads to fluctuations in cerebral blood flow (CBF). The relationship between fluctuations in CBF and those in CPP provides insight into the impact of the regulation of vascular resistance on CBF. The aim of this work was to study sleep-related changes in CBF regulation in newborn lambs, by quantifying the extent to which variability in CBF is related to that of CPP in the different wake-sleep states. Design: Repeated-measurement within-subject. Participants: 8 newborn lambs. Interventions: Chronic instrumentation with electrodes (electrocorticogram, electrooculogram, nuchal electromyogram), an arterial catheter (arterial pressure), a subdural catheter (intracranial pressure), and an ultrasonic flow probe around the superior sagittal sinus (CBF). Measurements and Results: The CPP (difference between arterial and intracranial pressure) and CBF data sequences during quiet wakefulness, rapid-e...ye-movement (REM) sleep and non-REM sleep were subject to spectral analysis. The fraction of CBF variability explained by CPP variability (CPP vs CBF squared coherence in the range 0.05-0.3 Hz) was highest in REM sleep (0.653) and lowest in non-REM sleep (0.413). The CBF variability (coefficient of variation due to fluctuations in the range 0.05-0.3 Hz) was higher than CPP variability in all states, albeit not significantly in REM sleep. Conclusions: Results suggest that synchronized vasomotor fluctuations accounting for a quota of CBF variability not explained by CPP variability occur in all states in newborn lambs. Their relative contribution to CBF variability differs among wake-sleep states, being highest during non-REM sleep and lowest during REM sleep.
Кључне речи:
sleep / cerebral blood flow / cerebral perfusion pressure / spectral analysis / newborn / sheepИзвор:
Sleep, 2004, 27, 1, 36-41
DOI: 10.1093/sleep/27.1.36
ISSN: 1550-9109
PubMed: 14998235
WoS: 000223168600007
Scopus: 2-s2.0-2442718004
Колекције
Институција/група
VinčaTY - JOUR AU - Silvani, Alessandro AU - Bojić, Tijana AU - Franzini, Carlo AU - Lenzi, Pierluigi AU - Walker, Adrian M AU - Grant, Daniel A AU - Wild, Jennene AU - Zoccoli, Giovanna PY - 2004 UR - https://vinar.vin.bg.ac.rs/handle/123456789/8874 AB - Study Objectives: The interplay between cerebral perfusion pressure (CPP) and vascular resistance leads to fluctuations in cerebral blood flow (CBF). The relationship between fluctuations in CBF and those in CPP provides insight into the impact of the regulation of vascular resistance on CBF. The aim of this work was to study sleep-related changes in CBF regulation in newborn lambs, by quantifying the extent to which variability in CBF is related to that of CPP in the different wake-sleep states. Design: Repeated-measurement within-subject. Participants: 8 newborn lambs. Interventions: Chronic instrumentation with electrodes (electrocorticogram, electrooculogram, nuchal electromyogram), an arterial catheter (arterial pressure), a subdural catheter (intracranial pressure), and an ultrasonic flow probe around the superior sagittal sinus (CBF). Measurements and Results: The CPP (difference between arterial and intracranial pressure) and CBF data sequences during quiet wakefulness, rapid-eye-movement (REM) sleep and non-REM sleep were subject to spectral analysis. The fraction of CBF variability explained by CPP variability (CPP vs CBF squared coherence in the range 0.05-0.3 Hz) was highest in REM sleep (0.653) and lowest in non-REM sleep (0.413). The CBF variability (coefficient of variation due to fluctuations in the range 0.05-0.3 Hz) was higher than CPP variability in all states, albeit not significantly in REM sleep. Conclusions: Results suggest that synchronized vasomotor fluctuations accounting for a quota of CBF variability not explained by CPP variability occur in all states in newborn lambs. Their relative contribution to CBF variability differs among wake-sleep states, being highest during non-REM sleep and lowest during REM sleep. T2 - Sleep T1 - Sleep-Related Changes in the Regulation of Cerebral Blood Flow in Newborn Lambs VL - 27 IS - 1 SP - 36 EP - 41 DO - 10.1093/sleep/27.1.36 ER -
@article{ author = "Silvani, Alessandro and Bojić, Tijana and Franzini, Carlo and Lenzi, Pierluigi and Walker, Adrian M and Grant, Daniel A and Wild, Jennene and Zoccoli, Giovanna", year = "2004", abstract = "Study Objectives: The interplay between cerebral perfusion pressure (CPP) and vascular resistance leads to fluctuations in cerebral blood flow (CBF). The relationship between fluctuations in CBF and those in CPP provides insight into the impact of the regulation of vascular resistance on CBF. The aim of this work was to study sleep-related changes in CBF regulation in newborn lambs, by quantifying the extent to which variability in CBF is related to that of CPP in the different wake-sleep states. Design: Repeated-measurement within-subject. Participants: 8 newborn lambs. Interventions: Chronic instrumentation with electrodes (electrocorticogram, electrooculogram, nuchal electromyogram), an arterial catheter (arterial pressure), a subdural catheter (intracranial pressure), and an ultrasonic flow probe around the superior sagittal sinus (CBF). Measurements and Results: The CPP (difference between arterial and intracranial pressure) and CBF data sequences during quiet wakefulness, rapid-eye-movement (REM) sleep and non-REM sleep were subject to spectral analysis. The fraction of CBF variability explained by CPP variability (CPP vs CBF squared coherence in the range 0.05-0.3 Hz) was highest in REM sleep (0.653) and lowest in non-REM sleep (0.413). The CBF variability (coefficient of variation due to fluctuations in the range 0.05-0.3 Hz) was higher than CPP variability in all states, albeit not significantly in REM sleep. Conclusions: Results suggest that synchronized vasomotor fluctuations accounting for a quota of CBF variability not explained by CPP variability occur in all states in newborn lambs. Their relative contribution to CBF variability differs among wake-sleep states, being highest during non-REM sleep and lowest during REM sleep.", journal = "Sleep", title = "Sleep-Related Changes in the Regulation of Cerebral Blood Flow in Newborn Lambs", volume = "27", number = "1", pages = "36-41", doi = "10.1093/sleep/27.1.36" }
Silvani, A., Bojić, T., Franzini, C., Lenzi, P., Walker, A. M., Grant, D. A., Wild, J.,& Zoccoli, G.. (2004). Sleep-Related Changes in the Regulation of Cerebral Blood Flow in Newborn Lambs. in Sleep, 27(1), 36-41. https://doi.org/10.1093/sleep/27.1.36
Silvani A, Bojić T, Franzini C, Lenzi P, Walker AM, Grant DA, Wild J, Zoccoli G. Sleep-Related Changes in the Regulation of Cerebral Blood Flow in Newborn Lambs. in Sleep. 2004;27(1):36-41. doi:10.1093/sleep/27.1.36 .
Silvani, Alessandro, Bojić, Tijana, Franzini, Carlo, Lenzi, Pierluigi, Walker, Adrian M, Grant, Daniel A, Wild, Jennene, Zoccoli, Giovanna, "Sleep-Related Changes in the Regulation of Cerebral Blood Flow in Newborn Lambs" in Sleep, 27, no. 1 (2004):36-41, https://doi.org/10.1093/sleep/27.1.36 . .