Graphene oxide size and structure pro-oxidant and antioxidant activity and photoinduced cytotoxicity relation on three cancer cell lines
Samo za registrovane korisnike
2019
Autori
Marković, Zoran M.Jovanović, Svetlana P.
Mašković, Pavle Z.
Mojsin, Marija
Stevanović, Milena J.
Danko, Martin
Mičušik, Matej
Jovanović, Dragana J.
Kleinova, Angela
Špitalsky, Zdeno
Pavlović, Vladimir B.
Todorović-Marković, Biljana
Članak u časopisu (Objavljena verzija)
,
© 2019 Elsevier B.V.
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Photoactive materials called photosensitizers can be used for treatment of different types of cancer in combination with light source. In this paper, we have investigated pro-oxidant and antioxidant potentials of four graphene based nanomaterials (graphene oxide-GO, graphene quantum dots-GQDs, carbon quantum dots-CQDs and N-doped carbon quantum dots-N-CQDs) depending on the presence/absence of visible light source. Structural and optical properties of these materials and their potentials for reactive oxygen species generation/quenching are investigated by applying different microscopy and spectroscopy techniques (transmission electron microscopy, FTIR, UV–Vis, photoluminescence, electron paramagnetic resonance). Results show that all types of quantum dots has pro-oxidant and antioxidant potentials whereas GO demonstrated only moderate antioxidant effect. The best free radical scavenger is CQDs sample in the absence of light. CQDs are the best singlet oxygen generator under blue light i...rradiation as well. To check photo-cytotoxicity of these materials, photo-cytotoxic concentrations of the GO, GQDs, CQDs and N-CQDs were determined for three cellular lines: human rhabdomyosarcoma (RD), cell line derived from human cervix carcinoma Hep2c (HeLa) and fibroblast cell line from murine (L2OB). Cytotoxicity test has indicated that all samples are much less photocytotoxic than cis-diamminedichloroplatinum (cis-DPP). The production method and doping of quantum dots affect the photodynamic activity of tested samples very much.
Ključne reči:
Graphene oxide / Graphene quantum dots / Carbon quantum dots / Reactive oxygen speciesIzvor:
Journal of Photochemistry and Photobiology B: Biology, 2019, 200, 111647-Finansiranje / projekti:
- Tanki slojevi jednoslojnih ugljeničnih nanotuba i grafena za primenu u elektronici (RS-MESTD-Basic Research (BR or ON)-172003)
- Proučavanje signalnih puteva i epigenetičkih mehanizama uključenih u kontrolu ekspresije humanih SOX gena: dalje rasvetljavanje njihove uloge u određivanju sudbine i diferencijaciji ćelija (RS-MESTD-Basic Research (BR or ON)-173051)
- Vedecka grantova agentura MSVVaS SR a SAV (VEGA) [2/0093/16]
DOI: 10.1016/j.jphotobiol.2019.111647
ISSN: 1011-1344
PubMed: 31648133
WoS: 000499768400002
Scopus: 2-s2.0-85073508959
Institucija/grupa
VinčaTY - JOUR AU - Marković, Zoran M. AU - Jovanović, Svetlana P. AU - Mašković, Pavle Z. AU - Mojsin, Marija AU - Stevanović, Milena J. AU - Danko, Martin AU - Mičušik, Matej AU - Jovanović, Dragana J. AU - Kleinova, Angela AU - Špitalsky, Zdeno AU - Pavlović, Vladimir B. AU - Todorović-Marković, Biljana PY - 2019 UR - https://vinar.vin.bg.ac.rs/handle/123456789/8591 AB - Photoactive materials called photosensitizers can be used for treatment of different types of cancer in combination with light source. In this paper, we have investigated pro-oxidant and antioxidant potentials of four graphene based nanomaterials (graphene oxide-GO, graphene quantum dots-GQDs, carbon quantum dots-CQDs and N-doped carbon quantum dots-N-CQDs) depending on the presence/absence of visible light source. Structural and optical properties of these materials and their potentials for reactive oxygen species generation/quenching are investigated by applying different microscopy and spectroscopy techniques (transmission electron microscopy, FTIR, UV–Vis, photoluminescence, electron paramagnetic resonance). Results show that all types of quantum dots has pro-oxidant and antioxidant potentials whereas GO demonstrated only moderate antioxidant effect. The best free radical scavenger is CQDs sample in the absence of light. CQDs are the best singlet oxygen generator under blue light irradiation as well. To check photo-cytotoxicity of these materials, photo-cytotoxic concentrations of the GO, GQDs, CQDs and N-CQDs were determined for three cellular lines: human rhabdomyosarcoma (RD), cell line derived from human cervix carcinoma Hep2c (HeLa) and fibroblast cell line from murine (L2OB). Cytotoxicity test has indicated that all samples are much less photocytotoxic than cis-diamminedichloroplatinum (cis-DPP). The production method and doping of quantum dots affect the photodynamic activity of tested samples very much. T2 - Journal of Photochemistry and Photobiology B: Biology T1 - Graphene oxide size and structure pro-oxidant and antioxidant activity and photoinduced cytotoxicity relation on three cancer cell lines VL - 200 SP - 111647 DO - 10.1016/j.jphotobiol.2019.111647 ER -
@article{ author = "Marković, Zoran M. and Jovanović, Svetlana P. and Mašković, Pavle Z. and Mojsin, Marija and Stevanović, Milena J. and Danko, Martin and Mičušik, Matej and Jovanović, Dragana J. and Kleinova, Angela and Špitalsky, Zdeno and Pavlović, Vladimir B. and Todorović-Marković, Biljana", year = "2019", abstract = "Photoactive materials called photosensitizers can be used for treatment of different types of cancer in combination with light source. In this paper, we have investigated pro-oxidant and antioxidant potentials of four graphene based nanomaterials (graphene oxide-GO, graphene quantum dots-GQDs, carbon quantum dots-CQDs and N-doped carbon quantum dots-N-CQDs) depending on the presence/absence of visible light source. Structural and optical properties of these materials and their potentials for reactive oxygen species generation/quenching are investigated by applying different microscopy and spectroscopy techniques (transmission electron microscopy, FTIR, UV–Vis, photoluminescence, electron paramagnetic resonance). Results show that all types of quantum dots has pro-oxidant and antioxidant potentials whereas GO demonstrated only moderate antioxidant effect. The best free radical scavenger is CQDs sample in the absence of light. CQDs are the best singlet oxygen generator under blue light irradiation as well. To check photo-cytotoxicity of these materials, photo-cytotoxic concentrations of the GO, GQDs, CQDs and N-CQDs were determined for three cellular lines: human rhabdomyosarcoma (RD), cell line derived from human cervix carcinoma Hep2c (HeLa) and fibroblast cell line from murine (L2OB). Cytotoxicity test has indicated that all samples are much less photocytotoxic than cis-diamminedichloroplatinum (cis-DPP). The production method and doping of quantum dots affect the photodynamic activity of tested samples very much.", journal = "Journal of Photochemistry and Photobiology B: Biology", title = "Graphene oxide size and structure pro-oxidant and antioxidant activity and photoinduced cytotoxicity relation on three cancer cell lines", volume = "200", pages = "111647", doi = "10.1016/j.jphotobiol.2019.111647" }
Marković, Z. M., Jovanović, S. P., Mašković, P. Z., Mojsin, M., Stevanović, M. J., Danko, M., Mičušik, M., Jovanović, D. J., Kleinova, A., Špitalsky, Z., Pavlović, V. B.,& Todorović-Marković, B.. (2019). Graphene oxide size and structure pro-oxidant and antioxidant activity and photoinduced cytotoxicity relation on three cancer cell lines. in Journal of Photochemistry and Photobiology B: Biology, 200, 111647. https://doi.org/10.1016/j.jphotobiol.2019.111647
Marković ZM, Jovanović SP, Mašković PZ, Mojsin M, Stevanović MJ, Danko M, Mičušik M, Jovanović DJ, Kleinova A, Špitalsky Z, Pavlović VB, Todorović-Marković B. Graphene oxide size and structure pro-oxidant and antioxidant activity and photoinduced cytotoxicity relation on three cancer cell lines. in Journal of Photochemistry and Photobiology B: Biology. 2019;200:111647. doi:10.1016/j.jphotobiol.2019.111647 .
Marković, Zoran M., Jovanović, Svetlana P., Mašković, Pavle Z., Mojsin, Marija, Stevanović, Milena J., Danko, Martin, Mičušik, Matej, Jovanović, Dragana J., Kleinova, Angela, Špitalsky, Zdeno, Pavlović, Vladimir B., Todorović-Marković, Biljana, "Graphene oxide size and structure pro-oxidant and antioxidant activity and photoinduced cytotoxicity relation on three cancer cell lines" in Journal of Photochemistry and Photobiology B: Biology, 200 (2019):111647, https://doi.org/10.1016/j.jphotobiol.2019.111647 . .