Cohesion and the aneuploid phenotype in Alzheimers disease: A tale of genome instability
Abstract
Neurons are postmitotic cells that are in permanent cell cycle arrest. However, components of the cell cycle machinery that are expressed in Alzheimers disease (AD) neurons are showing features of a cycling cell and those attributed to a postmitotic cell as well. Furthermore, the unique physiological operations taking place in neurons, ascribed to core cell cycle regulators are also key regulators in cell division. Functions of these cell cycle regulators include neuronal migration, axonal elongation, axon pruning, dendrite morphogenesis and synaptic maturation and plasticity. In this review, we focus on cohesion and cohesion related proteins in reference to their neuronal functions and how impaired centromere/cohesion dynamics may connect cell cycle dysfunction to aneuploidy in AD. (C) 2015 Elsevier Ltd. All rights reserved.
Keywords:
Alzheimers disease (AD) / Aneuploidy / Genomic mosaicism / Cell cycle / CohesionSource:
Neuroscience and Biobehavioral Reviews, 2015, 55, 365-374Funding / projects:
- Cell Cycle Aberrations and the Impact of Oxidative Stress in Neurodegenerative Processes and Malignant Transformation of the Cell (RS-MESTD-Basic Research (BR or ON)-173034)
DOI: 10.1016/j.neubiorev.2015.05.010
ISSN: 0149-7634; 1873-7528
PubMed: 26003528
WoS: 000358271000025
Scopus: 2-s2.0-84930622205
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VinčaTY - JOUR AU - Bajić, Vladan P. AU - Spremo-Potparević, Biljana AU - Živković, Lada AU - Isenović, Esma R. AU - Arendt, Thomas PY - 2015 UR - https://vinar.vin.bg.ac.rs/handle/123456789/664 AB - Neurons are postmitotic cells that are in permanent cell cycle arrest. However, components of the cell cycle machinery that are expressed in Alzheimers disease (AD) neurons are showing features of a cycling cell and those attributed to a postmitotic cell as well. Furthermore, the unique physiological operations taking place in neurons, ascribed to core cell cycle regulators are also key regulators in cell division. Functions of these cell cycle regulators include neuronal migration, axonal elongation, axon pruning, dendrite morphogenesis and synaptic maturation and plasticity. In this review, we focus on cohesion and cohesion related proteins in reference to their neuronal functions and how impaired centromere/cohesion dynamics may connect cell cycle dysfunction to aneuploidy in AD. (C) 2015 Elsevier Ltd. All rights reserved. T2 - Neuroscience and Biobehavioral Reviews T1 - Cohesion and the aneuploid phenotype in Alzheimers disease: A tale of genome instability VL - 55 SP - 365 EP - 374 DO - 10.1016/j.neubiorev.2015.05.010 ER -
@article{ author = "Bajić, Vladan P. and Spremo-Potparević, Biljana and Živković, Lada and Isenović, Esma R. and Arendt, Thomas", year = "2015", abstract = "Neurons are postmitotic cells that are in permanent cell cycle arrest. However, components of the cell cycle machinery that are expressed in Alzheimers disease (AD) neurons are showing features of a cycling cell and those attributed to a postmitotic cell as well. Furthermore, the unique physiological operations taking place in neurons, ascribed to core cell cycle regulators are also key regulators in cell division. Functions of these cell cycle regulators include neuronal migration, axonal elongation, axon pruning, dendrite morphogenesis and synaptic maturation and plasticity. In this review, we focus on cohesion and cohesion related proteins in reference to their neuronal functions and how impaired centromere/cohesion dynamics may connect cell cycle dysfunction to aneuploidy in AD. (C) 2015 Elsevier Ltd. All rights reserved.", journal = "Neuroscience and Biobehavioral Reviews", title = "Cohesion and the aneuploid phenotype in Alzheimers disease: A tale of genome instability", volume = "55", pages = "365-374", doi = "10.1016/j.neubiorev.2015.05.010" }
Bajić, V. P., Spremo-Potparević, B., Živković, L., Isenović, E. R.,& Arendt, T.. (2015). Cohesion and the aneuploid phenotype in Alzheimers disease: A tale of genome instability. in Neuroscience and Biobehavioral Reviews, 55, 365-374. https://doi.org/10.1016/j.neubiorev.2015.05.010
Bajić VP, Spremo-Potparević B, Živković L, Isenović ER, Arendt T. Cohesion and the aneuploid phenotype in Alzheimers disease: A tale of genome instability. in Neuroscience and Biobehavioral Reviews. 2015;55:365-374. doi:10.1016/j.neubiorev.2015.05.010 .
Bajić, Vladan P., Spremo-Potparević, Biljana, Živković, Lada, Isenović, Esma R., Arendt, Thomas, "Cohesion and the aneuploid phenotype in Alzheimers disease: A tale of genome instability" in Neuroscience and Biobehavioral Reviews, 55 (2015):365-374, https://doi.org/10.1016/j.neubiorev.2015.05.010 . .