Effect of Astaxanthin Supplementation on Paraoxonase 1 Activities and Oxidative Stress Status in Young Soccer Players
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Baralic, IvanaĐorđević, Brižita
Dikic, Nenad
Kotur-Stevuljevic, Jelena
Spasic, Slavica
Jelić-Ivanović, Zorana
Radivojevic, Nenad
Anđelković, Marija
Pejić, Snežana
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The purpose of the study was to examine the effects of astaxanthin (Asx) on paraoxonase (PON1) activities and oxidative stress status in soccer players. Forty soccer players were randomly assigned in a double-blind fashion to Asx and placebo (P) group. Blood samples were obtained before, 45 and 90days after supplementation. PON1 activity was assessed by using two substrates: paraoxon and diazoxon. The oxidative stress biomarkers were also examined: total sulphydryl group content (-SH groups), thiobarbituric acid-reactive substances (TBARS), advanced oxidation protein products and redox balance. The significant interaction effect of supplementation and training (p LT 0.05) on PON1 activity toward paraoxon was observed. The PON1 activity toward diazoxon increased in Asx group after 90days (p LT 0.01), while there was no significant difference in P group. SH groups content rose from pre- to post-supplementation period only in Asx group (supplementation and training, p LT 0.05; training, p... LT 0.01). TBARS levels decreased after 45days and increased after 90days of regular soccer training in both groups (training, p LT 0.001). Redox balance decreased significantly in response to the regular training, regardless of treatment group (training, p LT 0.001). Asx supplementation might increase total SH groups content and improve PON1 activity through protection of free thiol groups against oxidative modification. Copyright (c) 2012 John Wiley and Sons, Ltd.
Keywords:
astaxanthin / soccer / paraoxonase 1 activity / oxidative stressSource:
Phytotherapy Research, 2013, 27, 10, 1536-1542Funding / projects:
- Interactive role of dyslipidemia, oxidative stress and inflammation in atherosclerosis and other diseases: genetic and biochemical markers (RS-MESTD-Basic Research (BR or ON)-175035)
- Cellular and molecular basis of malignant and cardiovascular diseases-clinical implications (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41027)
- Develooment and utilization of novel and traditional technologies in production of competitive food products with added valued for national and global market - CREATING WEALTH FROM THE WEALTH OF SERBIA (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-46001)
DOI: 10.1002/ptr.4898
ISSN: 0951-418X
PubMed: 23192897
WoS: 000325365700013
Scopus: 2-s2.0-84885648766
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VinčaTY - JOUR AU - Baralic, Ivana AU - Đorđević, Brižita AU - Dikic, Nenad AU - Kotur-Stevuljevic, Jelena AU - Spasic, Slavica AU - Jelić-Ivanović, Zorana AU - Radivojevic, Nenad AU - Anđelković, Marija AU - Pejić, Snežana PY - 2013 UR - https://vinar.vin.bg.ac.rs/handle/123456789/5713 AB - The purpose of the study was to examine the effects of astaxanthin (Asx) on paraoxonase (PON1) activities and oxidative stress status in soccer players. Forty soccer players were randomly assigned in a double-blind fashion to Asx and placebo (P) group. Blood samples were obtained before, 45 and 90days after supplementation. PON1 activity was assessed by using two substrates: paraoxon and diazoxon. The oxidative stress biomarkers were also examined: total sulphydryl group content (-SH groups), thiobarbituric acid-reactive substances (TBARS), advanced oxidation protein products and redox balance. The significant interaction effect of supplementation and training (p LT 0.05) on PON1 activity toward paraoxon was observed. The PON1 activity toward diazoxon increased in Asx group after 90days (p LT 0.01), while there was no significant difference in P group. SH groups content rose from pre- to post-supplementation period only in Asx group (supplementation and training, p LT 0.05; training, p LT 0.01). TBARS levels decreased after 45days and increased after 90days of regular soccer training in both groups (training, p LT 0.001). Redox balance decreased significantly in response to the regular training, regardless of treatment group (training, p LT 0.001). Asx supplementation might increase total SH groups content and improve PON1 activity through protection of free thiol groups against oxidative modification. Copyright (c) 2012 John Wiley and Sons, Ltd. T2 - Phytotherapy Research T1 - Effect of Astaxanthin Supplementation on Paraoxonase 1 Activities and Oxidative Stress Status in Young Soccer Players VL - 27 IS - 10 SP - 1536 EP - 1542 DO - 10.1002/ptr.4898 ER -
@article{ author = "Baralic, Ivana and Đorđević, Brižita and Dikic, Nenad and Kotur-Stevuljevic, Jelena and Spasic, Slavica and Jelić-Ivanović, Zorana and Radivojevic, Nenad and Anđelković, Marija and Pejić, Snežana", year = "2013", abstract = "The purpose of the study was to examine the effects of astaxanthin (Asx) on paraoxonase (PON1) activities and oxidative stress status in soccer players. Forty soccer players were randomly assigned in a double-blind fashion to Asx and placebo (P) group. Blood samples were obtained before, 45 and 90days after supplementation. PON1 activity was assessed by using two substrates: paraoxon and diazoxon. The oxidative stress biomarkers were also examined: total sulphydryl group content (-SH groups), thiobarbituric acid-reactive substances (TBARS), advanced oxidation protein products and redox balance. The significant interaction effect of supplementation and training (p LT 0.05) on PON1 activity toward paraoxon was observed. The PON1 activity toward diazoxon increased in Asx group after 90days (p LT 0.01), while there was no significant difference in P group. SH groups content rose from pre- to post-supplementation period only in Asx group (supplementation and training, p LT 0.05; training, p LT 0.01). TBARS levels decreased after 45days and increased after 90days of regular soccer training in both groups (training, p LT 0.001). Redox balance decreased significantly in response to the regular training, regardless of treatment group (training, p LT 0.001). Asx supplementation might increase total SH groups content and improve PON1 activity through protection of free thiol groups against oxidative modification. Copyright (c) 2012 John Wiley and Sons, Ltd.", journal = "Phytotherapy Research", title = "Effect of Astaxanthin Supplementation on Paraoxonase 1 Activities and Oxidative Stress Status in Young Soccer Players", volume = "27", number = "10", pages = "1536-1542", doi = "10.1002/ptr.4898" }
Baralic, I., Đorđević, B., Dikic, N., Kotur-Stevuljevic, J., Spasic, S., Jelić-Ivanović, Z., Radivojevic, N., Anđelković, M.,& Pejić, S.. (2013). Effect of Astaxanthin Supplementation on Paraoxonase 1 Activities and Oxidative Stress Status in Young Soccer Players. in Phytotherapy Research, 27(10), 1536-1542. https://doi.org/10.1002/ptr.4898
Baralic I, Đorđević B, Dikic N, Kotur-Stevuljevic J, Spasic S, Jelić-Ivanović Z, Radivojevic N, Anđelković M, Pejić S. Effect of Astaxanthin Supplementation on Paraoxonase 1 Activities and Oxidative Stress Status in Young Soccer Players. in Phytotherapy Research. 2013;27(10):1536-1542. doi:10.1002/ptr.4898 .
Baralic, Ivana, Đorđević, Brižita, Dikic, Nenad, Kotur-Stevuljevic, Jelena, Spasic, Slavica, Jelić-Ivanović, Zorana, Radivojevic, Nenad, Anđelković, Marija, Pejić, Snežana, "Effect of Astaxanthin Supplementation on Paraoxonase 1 Activities and Oxidative Stress Status in Young Soccer Players" in Phytotherapy Research, 27, no. 10 (2013):1536-1542, https://doi.org/10.1002/ptr.4898 . .