Inhibitory effect of cisplatin and [Pt(dach)Cl2] on the activity of phospholipase A2
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This work has been focused on testing the influence of two selected Pt(II) complexes cisplatin, Pt(NH3)(2) Cl-2, and [Pt(dach)Cl-2] on the activity of porcine pancreatic phospholipase A(2) (PLA(2)). It has been assumed that this enzyme plays a role in carcinogenesis and that it could be a target in the tumour therapy. The results of this study show that both Pt(II) complexes inhibit the activity of the enzyme, though they bind to it in a different manner. While cisplatin interacts with the enzyme in an acompetitive manner, the stable interaction of [Pt(dach)Cl-2] with PLA(2) could not be detected under our experimental conditions.
Ključne reči:
MALDI TOF MS / metallo-drugs / phosphatidylcholineIzvor:
Journal of Enzyme Inhibition and Medicinal Chemistry, 2013, 28, 4, 651-660Finansiranje / projekti:
- Ispitivanje mehanizma reakcija kompleksa jona prelaznih metala sa biološki značajnim molekulima (RS-MESTD-Basic Research (BR or ON)-172011)
DOI: 10.3109/14756366.2012.666539
ISSN: 1475-6366
PubMed: 22424180
WoS: 000321693400001
Scopus: 2-s2.0-84880057888
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VinčaTY - JOUR AU - Radisavljevic, Maja AU - Kamceva, Tina AU - Bugarčić, Živadin D. AU - Petković, Marijana PY - 2013 UR - https://vinar.vin.bg.ac.rs/handle/123456789/5583 AB - This work has been focused on testing the influence of two selected Pt(II) complexes cisplatin, Pt(NH3)(2) Cl-2, and [Pt(dach)Cl-2] on the activity of porcine pancreatic phospholipase A(2) (PLA(2)). It has been assumed that this enzyme plays a role in carcinogenesis and that it could be a target in the tumour therapy. The results of this study show that both Pt(II) complexes inhibit the activity of the enzyme, though they bind to it in a different manner. While cisplatin interacts with the enzyme in an acompetitive manner, the stable interaction of [Pt(dach)Cl-2] with PLA(2) could not be detected under our experimental conditions. T2 - Journal of Enzyme Inhibition and Medicinal Chemistry T1 - Inhibitory effect of cisplatin and [Pt(dach)Cl2] on the activity of phospholipase A2 VL - 28 IS - 4 SP - 651 EP - 660 DO - 10.3109/14756366.2012.666539 ER -
@article{ author = "Radisavljevic, Maja and Kamceva, Tina and Bugarčić, Živadin D. and Petković, Marijana", year = "2013", abstract = "This work has been focused on testing the influence of two selected Pt(II) complexes cisplatin, Pt(NH3)(2) Cl-2, and [Pt(dach)Cl-2] on the activity of porcine pancreatic phospholipase A(2) (PLA(2)). It has been assumed that this enzyme plays a role in carcinogenesis and that it could be a target in the tumour therapy. The results of this study show that both Pt(II) complexes inhibit the activity of the enzyme, though they bind to it in a different manner. While cisplatin interacts with the enzyme in an acompetitive manner, the stable interaction of [Pt(dach)Cl-2] with PLA(2) could not be detected under our experimental conditions.", journal = "Journal of Enzyme Inhibition and Medicinal Chemistry", title = "Inhibitory effect of cisplatin and [Pt(dach)Cl2] on the activity of phospholipase A2", volume = "28", number = "4", pages = "651-660", doi = "10.3109/14756366.2012.666539" }
Radisavljevic, M., Kamceva, T., Bugarčić, Ž. D.,& Petković, M.. (2013). Inhibitory effect of cisplatin and [Pt(dach)Cl2] on the activity of phospholipase A2. in Journal of Enzyme Inhibition and Medicinal Chemistry, 28(4), 651-660. https://doi.org/10.3109/14756366.2012.666539
Radisavljevic M, Kamceva T, Bugarčić ŽD, Petković M. Inhibitory effect of cisplatin and [Pt(dach)Cl2] on the activity of phospholipase A2. in Journal of Enzyme Inhibition and Medicinal Chemistry. 2013;28(4):651-660. doi:10.3109/14756366.2012.666539 .
Radisavljevic, Maja, Kamceva, Tina, Bugarčić, Živadin D., Petković, Marijana, "Inhibitory effect of cisplatin and [Pt(dach)Cl2] on the activity of phospholipase A2" in Journal of Enzyme Inhibition and Medicinal Chemistry, 28, no. 4 (2013):651-660, https://doi.org/10.3109/14756366.2012.666539 . .