The role of G protein coupled receptor kinases in neurocardiovascular pathophysiology
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In coronary artery disease the G protein related kinases (GRKs) play a role in desensitization of beta-adrenoreceptors (AR) after coronary occlusion. Targeted deletion and lowering of cardiac myocyte GRK-2 decreases the risk of post-ischemic heart failure (HF). Studies carried out in humans confirm the role of GRK-2 as a marker for the progression of HF after myocardial infarction (MI). The level of GRK-2 could be an indicator of beta-AR blocker efficacy in patients with acute coronary syndrome. Elevated levels of GRK-2 are an early ubiquitous consequence of myocardial injury. In hypertension an increased level of GRK-2 was reported in both animal models and human studies. The role of GRKs in vagally mediated disorders such as vasovagal syncope and atrial fibrillation remains controversial. The role of GRKs in the pathogenesis of neurocardiological diseases provides an insight into the molecular pathogenesis process, opens potential therapeutic options and suggests new directions for s...cientific research.
Keywords:
autonomic / sympathetic / vagal / molecular signaling pathwaySource:
Archives of Medical Science, 2012, 8, 6, 970-977Funding / projects:
- Hormonal regulation of expression and activity of the nitric oxide synthase and sodium-potassium pump in experimental models of insulin resistance, diabetes and cardiovascular disorders (RS-MESTD-Basic Research (BR or ON)-173033)
- An integral study to identify the regional genetic and environmental risk factors for the common noncommunicable diseases in the human population of Serbia - INGEMA_S (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41028)
DOI: 10.5114/aoms.2012.32466
ISSN: 1734-1922
PubMed: 23319968
WoS: 000312926600004
Scopus: 2-s2.0-84873168698
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VinčaTY - JOUR AU - Bojić, Tijana AU - Sudar, Emina AU - Mikhailidis, Dimitri P. AU - Alavantić, Dragan AU - Isenović, Esma R. PY - 2012 UR - https://vinar.vin.bg.ac.rs/handle/123456789/5232 AB - In coronary artery disease the G protein related kinases (GRKs) play a role in desensitization of beta-adrenoreceptors (AR) after coronary occlusion. Targeted deletion and lowering of cardiac myocyte GRK-2 decreases the risk of post-ischemic heart failure (HF). Studies carried out in humans confirm the role of GRK-2 as a marker for the progression of HF after myocardial infarction (MI). The level of GRK-2 could be an indicator of beta-AR blocker efficacy in patients with acute coronary syndrome. Elevated levels of GRK-2 are an early ubiquitous consequence of myocardial injury. In hypertension an increased level of GRK-2 was reported in both animal models and human studies. The role of GRKs in vagally mediated disorders such as vasovagal syncope and atrial fibrillation remains controversial. The role of GRKs in the pathogenesis of neurocardiological diseases provides an insight into the molecular pathogenesis process, opens potential therapeutic options and suggests new directions for scientific research. T2 - Archives of Medical Science T1 - The role of G protein coupled receptor kinases in neurocardiovascular pathophysiology VL - 8 IS - 6 SP - 970 EP - 977 DO - 10.5114/aoms.2012.32466 ER -
@article{ author = "Bojić, Tijana and Sudar, Emina and Mikhailidis, Dimitri P. and Alavantić, Dragan and Isenović, Esma R.", year = "2012", abstract = "In coronary artery disease the G protein related kinases (GRKs) play a role in desensitization of beta-adrenoreceptors (AR) after coronary occlusion. Targeted deletion and lowering of cardiac myocyte GRK-2 decreases the risk of post-ischemic heart failure (HF). Studies carried out in humans confirm the role of GRK-2 as a marker for the progression of HF after myocardial infarction (MI). The level of GRK-2 could be an indicator of beta-AR blocker efficacy in patients with acute coronary syndrome. Elevated levels of GRK-2 are an early ubiquitous consequence of myocardial injury. In hypertension an increased level of GRK-2 was reported in both animal models and human studies. The role of GRKs in vagally mediated disorders such as vasovagal syncope and atrial fibrillation remains controversial. The role of GRKs in the pathogenesis of neurocardiological diseases provides an insight into the molecular pathogenesis process, opens potential therapeutic options and suggests new directions for scientific research.", journal = "Archives of Medical Science", title = "The role of G protein coupled receptor kinases in neurocardiovascular pathophysiology", volume = "8", number = "6", pages = "970-977", doi = "10.5114/aoms.2012.32466" }
Bojić, T., Sudar, E., Mikhailidis, D. P., Alavantić, D.,& Isenović, E. R.. (2012). The role of G protein coupled receptor kinases in neurocardiovascular pathophysiology. in Archives of Medical Science, 8(6), 970-977. https://doi.org/10.5114/aoms.2012.32466
Bojić T, Sudar E, Mikhailidis DP, Alavantić D, Isenović ER. The role of G protein coupled receptor kinases in neurocardiovascular pathophysiology. in Archives of Medical Science. 2012;8(6):970-977. doi:10.5114/aoms.2012.32466 .
Bojić, Tijana, Sudar, Emina, Mikhailidis, Dimitri P., Alavantić, Dragan, Isenović, Esma R., "The role of G protein coupled receptor kinases in neurocardiovascular pathophysiology" in Archives of Medical Science, 8, no. 6 (2012):970-977, https://doi.org/10.5114/aoms.2012.32466 . .