Matrix metalloproteinase-1 promoter genotypes and haplotypes are associated with carotid plaque presence
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Đurić, TamaraStojković, Ljiljana S.
Živković, Maja
Končar, Igor
Stanković, Aleksandra
Đorđević, Ana
Alavantić, Dragan
Article (Published version)
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Objectives: Matrix metalloproteinase (MMP)-1 degrades fibrillar collagens suggesting important role in vascular remodeling. Data about MMP-1 promoter polymorphisms and carotid atherosclerosis (CA) are scarce. The aim of this study was to evaluate association of MMP-1 genotypes/haplotypes with carotid plaque (CP) presence in Serbian population. Design and methods: Study enrolled a total of 702 participants: 274 controls and 428 consecutive patients with CA who underwent carotid endarterectomy. MMP-1 polymorphisms -1607 1G/2G, -519 A/G and -340 T/C were genotyped by PCR and RFLP methods. Results: Individuals carrying MMP-1 - 1607 2G allele had significantly increased allele dose-dependent risk for CP presence (1G1G vs. 1G2G vs. 2G2G; OR = 1; OR = 1.87 95% CI 1.29-2.07; OR= 3.49 95% CI 1.67-7.30. p = 0.0009, respectively). Compared to the referent haplotype 2G_ (1607)-T_ (340)-A_(519), the haplotypes 1G_(1607)-T_(340)-A_(519), 1G-(1607)-T_(340)-G_519 and 2G_(1607)-C_(340)-A_(519) had stat...istically significant protective effect on CP presence (OR = 0.41, 95% CI 0.29-0.81, p = 0.01; OR = 0.56, 95% CI 0.44-0.89, p = 0.01: OR = 0.43, 95% CI 0.27-0.86, p = 0.02, respectively). Conclusions: MMP-1 - 1607 G/2G polymorphism solely and specific haplotypes of three analyzed promoter polymorphisms are significantly and independently associated with occurrence of CP. Replication studies in other populations are needed. (c) 2012 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.
Keywords:
Matrix metalloproteinase-1 / Carotid atherosclerosis / Polymorphisms / HaplotypesSource:
Clinical Biochemistry, 2012, 45, 16-17, 1353-1356Funding / projects:
- Genetic basis of human vascular and inflammatory diseases (RS-MESTD-Basic Research (BR or ON)-175085)
- An integral study to identify the regional genetic and environmental risk factors for the common noncommunicable diseases in the human population of Serbia - INGEMA_S (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41028)
DOI: 10.1016/j.clinbiochem.2012.05.032
ISSN: 0009-9120; 1873-2933
PubMed: 22683752
WoS: 000311064200015
Scopus: 2-s2.0-84868300482
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VinčaTY - JOUR AU - Đurić, Tamara AU - Stojković, Ljiljana S. AU - Živković, Maja AU - Končar, Igor AU - Stanković, Aleksandra AU - Đorđević, Ana AU - Alavantić, Dragan PY - 2012 UR - https://vinar.vin.bg.ac.rs/handle/123456789/5161 AB - Objectives: Matrix metalloproteinase (MMP)-1 degrades fibrillar collagens suggesting important role in vascular remodeling. Data about MMP-1 promoter polymorphisms and carotid atherosclerosis (CA) are scarce. The aim of this study was to evaluate association of MMP-1 genotypes/haplotypes with carotid plaque (CP) presence in Serbian population. Design and methods: Study enrolled a total of 702 participants: 274 controls and 428 consecutive patients with CA who underwent carotid endarterectomy. MMP-1 polymorphisms -1607 1G/2G, -519 A/G and -340 T/C were genotyped by PCR and RFLP methods. Results: Individuals carrying MMP-1 - 1607 2G allele had significantly increased allele dose-dependent risk for CP presence (1G1G vs. 1G2G vs. 2G2G; OR = 1; OR = 1.87 95% CI 1.29-2.07; OR= 3.49 95% CI 1.67-7.30. p = 0.0009, respectively). Compared to the referent haplotype 2G_ (1607)-T_ (340)-A_(519), the haplotypes 1G_(1607)-T_(340)-A_(519), 1G-(1607)-T_(340)-G_519 and 2G_(1607)-C_(340)-A_(519) had statistically significant protective effect on CP presence (OR = 0.41, 95% CI 0.29-0.81, p = 0.01; OR = 0.56, 95% CI 0.44-0.89, p = 0.01: OR = 0.43, 95% CI 0.27-0.86, p = 0.02, respectively). Conclusions: MMP-1 - 1607 G/2G polymorphism solely and specific haplotypes of three analyzed promoter polymorphisms are significantly and independently associated with occurrence of CP. Replication studies in other populations are needed. (c) 2012 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved. T2 - Clinical Biochemistry T1 - Matrix metalloproteinase-1 promoter genotypes and haplotypes are associated with carotid plaque presence VL - 45 IS - 16-17 SP - 1353 EP - 1356 DO - 10.1016/j.clinbiochem.2012.05.032 ER -
@article{ author = "Đurić, Tamara and Stojković, Ljiljana S. and Živković, Maja and Končar, Igor and Stanković, Aleksandra and Đorđević, Ana and Alavantić, Dragan", year = "2012", abstract = "Objectives: Matrix metalloproteinase (MMP)-1 degrades fibrillar collagens suggesting important role in vascular remodeling. Data about MMP-1 promoter polymorphisms and carotid atherosclerosis (CA) are scarce. The aim of this study was to evaluate association of MMP-1 genotypes/haplotypes with carotid plaque (CP) presence in Serbian population. Design and methods: Study enrolled a total of 702 participants: 274 controls and 428 consecutive patients with CA who underwent carotid endarterectomy. MMP-1 polymorphisms -1607 1G/2G, -519 A/G and -340 T/C were genotyped by PCR and RFLP methods. Results: Individuals carrying MMP-1 - 1607 2G allele had significantly increased allele dose-dependent risk for CP presence (1G1G vs. 1G2G vs. 2G2G; OR = 1; OR = 1.87 95% CI 1.29-2.07; OR= 3.49 95% CI 1.67-7.30. p = 0.0009, respectively). Compared to the referent haplotype 2G_ (1607)-T_ (340)-A_(519), the haplotypes 1G_(1607)-T_(340)-A_(519), 1G-(1607)-T_(340)-G_519 and 2G_(1607)-C_(340)-A_(519) had statistically significant protective effect on CP presence (OR = 0.41, 95% CI 0.29-0.81, p = 0.01; OR = 0.56, 95% CI 0.44-0.89, p = 0.01: OR = 0.43, 95% CI 0.27-0.86, p = 0.02, respectively). Conclusions: MMP-1 - 1607 G/2G polymorphism solely and specific haplotypes of three analyzed promoter polymorphisms are significantly and independently associated with occurrence of CP. Replication studies in other populations are needed. (c) 2012 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.", journal = "Clinical Biochemistry", title = "Matrix metalloproteinase-1 promoter genotypes and haplotypes are associated with carotid plaque presence", volume = "45", number = "16-17", pages = "1353-1356", doi = "10.1016/j.clinbiochem.2012.05.032" }
Đurić, T., Stojković, L. S., Živković, M., Končar, I., Stanković, A., Đorđević, A.,& Alavantić, D.. (2012). Matrix metalloproteinase-1 promoter genotypes and haplotypes are associated with carotid plaque presence. in Clinical Biochemistry, 45(16-17), 1353-1356. https://doi.org/10.1016/j.clinbiochem.2012.05.032
Đurić T, Stojković LS, Živković M, Končar I, Stanković A, Đorđević A, Alavantić D. Matrix metalloproteinase-1 promoter genotypes and haplotypes are associated with carotid plaque presence. in Clinical Biochemistry. 2012;45(16-17):1353-1356. doi:10.1016/j.clinbiochem.2012.05.032 .
Đurić, Tamara, Stojković, Ljiljana S., Živković, Maja, Končar, Igor, Stanković, Aleksandra, Đorđević, Ana, Alavantić, Dragan, "Matrix metalloproteinase-1 promoter genotypes and haplotypes are associated with carotid plaque presence" in Clinical Biochemistry, 45, no. 16-17 (2012):1353-1356, https://doi.org/10.1016/j.clinbiochem.2012.05.032 . .