Inhibition of Aldose Reductase by Gentiana lutea Extracts
2012
Authors
Akileshwari, ChandrasekharMuthenna, Puppala
Nastasijević, Branislav J.
Joksić, Gordana
Petrash, J. Mark
Reddy, Geereddy Bhanuprakash
Article
Metadata
Show full item recordAbstract
Accumulation of intracellular sorbitol due to increased aldose reductase (ALR2) activity has been implicated in the development of various secondary complications of diabetes. Thus, ALR2 inhibition could be an effective strategy in the prevention or delay of certain diabetic complications. Gentiana lutea grows naturally in the central and southern areas of Europe. Its roots are commonly consumed as a beverage in some European countries and are also known to have medicinal properties. The water, ethanol, methanol, and ether extracts of the roots of G. lutea were subjected to in vitro bioassay to evaluate their inhibitory activity on the ALR2. While the ether and methanol extracts showed greater inhibitory activities against both rat lens and human ALR2, the water and ethanol extracts showed moderate inhibitory activities. Moreover, the ether and methanol extracts of G. lutea roots significantly and dose-dependently inhibited sorbitol accumulation in human erythrocytes under high glucose... conditions. Molecular docking studies with the constituents commonly present in the roots of G. lutea indicate that a secoiridoid glycoside, amarogentin, may be a potential inhibitor of ALR2. This is the first paper that shows G. lutea extracts exhibit inhibitory activity towards ALR2 and these results suggest that Gentiana or its constituents might be useful to prevent or treat diabetic complications.
Source:
Experimental Diabetes Research, 2012Funding / projects:
- Impact of agents with potential use in functional foods on biomarkers for induction of age related diseases (EU-FP7-245030)
- Life Sciences Research Board of Defense Research and Development Organization, Government of India, Department of Biotechnology, University Grants Commission, India
DOI: 10.1155/2012/147965
ISSN: 1687-5214
WoS: 000307701900001
Scopus: 2-s2.0-84864943704
Collections
Institution/Community
VinčaTY - JOUR AU - Akileshwari, Chandrasekhar AU - Muthenna, Puppala AU - Nastasijević, Branislav J. AU - Joksić, Gordana AU - Petrash, J. Mark AU - Reddy, Geereddy Bhanuprakash PY - 2012 UR - https://vinar.vin.bg.ac.rs/handle/123456789/5006 AB - Accumulation of intracellular sorbitol due to increased aldose reductase (ALR2) activity has been implicated in the development of various secondary complications of diabetes. Thus, ALR2 inhibition could be an effective strategy in the prevention or delay of certain diabetic complications. Gentiana lutea grows naturally in the central and southern areas of Europe. Its roots are commonly consumed as a beverage in some European countries and are also known to have medicinal properties. The water, ethanol, methanol, and ether extracts of the roots of G. lutea were subjected to in vitro bioassay to evaluate their inhibitory activity on the ALR2. While the ether and methanol extracts showed greater inhibitory activities against both rat lens and human ALR2, the water and ethanol extracts showed moderate inhibitory activities. Moreover, the ether and methanol extracts of G. lutea roots significantly and dose-dependently inhibited sorbitol accumulation in human erythrocytes under high glucose conditions. Molecular docking studies with the constituents commonly present in the roots of G. lutea indicate that a secoiridoid glycoside, amarogentin, may be a potential inhibitor of ALR2. This is the first paper that shows G. lutea extracts exhibit inhibitory activity towards ALR2 and these results suggest that Gentiana or its constituents might be useful to prevent or treat diabetic complications. T2 - Experimental Diabetes Research T1 - Inhibition of Aldose Reductase by Gentiana lutea Extracts DO - 10.1155/2012/147965 ER -
@article{ author = "Akileshwari, Chandrasekhar and Muthenna, Puppala and Nastasijević, Branislav J. and Joksić, Gordana and Petrash, J. Mark and Reddy, Geereddy Bhanuprakash", year = "2012", abstract = "Accumulation of intracellular sorbitol due to increased aldose reductase (ALR2) activity has been implicated in the development of various secondary complications of diabetes. Thus, ALR2 inhibition could be an effective strategy in the prevention or delay of certain diabetic complications. Gentiana lutea grows naturally in the central and southern areas of Europe. Its roots are commonly consumed as a beverage in some European countries and are also known to have medicinal properties. The water, ethanol, methanol, and ether extracts of the roots of G. lutea were subjected to in vitro bioassay to evaluate their inhibitory activity on the ALR2. While the ether and methanol extracts showed greater inhibitory activities against both rat lens and human ALR2, the water and ethanol extracts showed moderate inhibitory activities. Moreover, the ether and methanol extracts of G. lutea roots significantly and dose-dependently inhibited sorbitol accumulation in human erythrocytes under high glucose conditions. Molecular docking studies with the constituents commonly present in the roots of G. lutea indicate that a secoiridoid glycoside, amarogentin, may be a potential inhibitor of ALR2. This is the first paper that shows G. lutea extracts exhibit inhibitory activity towards ALR2 and these results suggest that Gentiana or its constituents might be useful to prevent or treat diabetic complications.", journal = "Experimental Diabetes Research", title = "Inhibition of Aldose Reductase by Gentiana lutea Extracts", doi = "10.1155/2012/147965" }
Akileshwari, C., Muthenna, P., Nastasijević, B. J., Joksić, G., Petrash, J. M.,& Reddy, G. B.. (2012). Inhibition of Aldose Reductase by Gentiana lutea Extracts. in Experimental Diabetes Research. https://doi.org/10.1155/2012/147965
Akileshwari C, Muthenna P, Nastasijević BJ, Joksić G, Petrash JM, Reddy GB. Inhibition of Aldose Reductase by Gentiana lutea Extracts. in Experimental Diabetes Research. 2012;. doi:10.1155/2012/147965 .
Akileshwari, Chandrasekhar, Muthenna, Puppala, Nastasijević, Branislav J., Joksić, Gordana, Petrash, J. Mark, Reddy, Geereddy Bhanuprakash, "Inhibition of Aldose Reductase by Gentiana lutea Extracts" in Experimental Diabetes Research (2012), https://doi.org/10.1155/2012/147965 . .