The sex-specific association of Met62Ile gene polymorphism in P-selectin glycoprotein ligand (PSGL-1) with carotid plaque presence: preliminary study
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Аутори
Živković, MajaKolaković, Ana
Radak, Đorđe J.
Dinčić, Dragan
Radak, Sandra
Đurić, Tamara
Stanković, Aleksandra
Чланак у часопису
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Приказ свих података о документуАпстракт
Atherosclerosis is known as an inflammatory disease in which a recruitment of leukocytes to the endothelium wall represents a preliminary step of the initiation and the development of disease. The P-selectin glycoprotein ligand (PSGL-1) seems to be the major molecule mediating leukocyte-endothelium interactions and leukocyte rolling on stimulated endothelium. There are limited number of studies reporting on association of Met62Ile SNP in PSGL-1 gene and the risk for atherosclerosis. The aim of this study was to analyze possible association of this polymorphism with an advanced carotid atherosclerosis and biochemical markers of inflammation and haemostasis. The 275 patients consecutively admitted for carotid endarterectomy with stenosis GT 70% and 256 controls of the same ethnic origin were included in the study. The Met62Ile genotypes were determined by PCR RFLP. The Ile/Ile homozygotes had significantly higher CRP compared to the other genotypes in patients. Female patients had Ile al...lele dose-dependent association with the carotid plaque presence (Met/Met vs. Met/Ile vs. Ile/Ile; OR 1, OR 2.02, CI 1.0-4.08, OR 4.08, CI 1.0-16.81, respectively, p = 0.04). Our results suggest the impact of PSGL-1 Met62Ile polymorphism on inflammation in advanced atherosclerosis. We observed the sex-differential association of Met62Ile with advanced carotid atherosclerosis. Studies in larger and different populations should validate and further examine the suggested role of genetic variations in PSGL-1 with atherosclerosis and thrombosis.
Кључне речи:
PSGL-1 / Gene / Polymorphism / Sex-specific / Carotid atherosclerosisИзвор:
Molecular Biology Reports, 2012, 39, 6, 6479-6485Финансирање / пројекти:
- Генетска основа хуманих васкуларних и инфламаторних болести (RS-MESTD-Basic Research (BR or ON)-175085)
- Интегрална студија идентификације регионалних генетских фактора ризика и фактора ризика животне средине за масовне незаразне болести хумане популације у Србији - INGEMA_S (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41028)
DOI: 10.1007/s11033-012-1475-5
ISSN: 0301-4851
PubMed: 22307784
WoS: 000303351900009
Scopus: 2-s2.0-84864285008
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Институција/група
VinčaTY - JOUR AU - Živković, Maja AU - Kolaković, Ana AU - Radak, Đorđe J. AU - Dinčić, Dragan AU - Radak, Sandra AU - Đurić, Tamara AU - Stanković, Aleksandra PY - 2012 UR - https://vinar.vin.bg.ac.rs/handle/123456789/4823 AB - Atherosclerosis is known as an inflammatory disease in which a recruitment of leukocytes to the endothelium wall represents a preliminary step of the initiation and the development of disease. The P-selectin glycoprotein ligand (PSGL-1) seems to be the major molecule mediating leukocyte-endothelium interactions and leukocyte rolling on stimulated endothelium. There are limited number of studies reporting on association of Met62Ile SNP in PSGL-1 gene and the risk for atherosclerosis. The aim of this study was to analyze possible association of this polymorphism with an advanced carotid atherosclerosis and biochemical markers of inflammation and haemostasis. The 275 patients consecutively admitted for carotid endarterectomy with stenosis GT 70% and 256 controls of the same ethnic origin were included in the study. The Met62Ile genotypes were determined by PCR RFLP. The Ile/Ile homozygotes had significantly higher CRP compared to the other genotypes in patients. Female patients had Ile allele dose-dependent association with the carotid plaque presence (Met/Met vs. Met/Ile vs. Ile/Ile; OR 1, OR 2.02, CI 1.0-4.08, OR 4.08, CI 1.0-16.81, respectively, p = 0.04). Our results suggest the impact of PSGL-1 Met62Ile polymorphism on inflammation in advanced atherosclerosis. We observed the sex-differential association of Met62Ile with advanced carotid atherosclerosis. Studies in larger and different populations should validate and further examine the suggested role of genetic variations in PSGL-1 with atherosclerosis and thrombosis. T2 - Molecular Biology Reports T1 - The sex-specific association of Met62Ile gene polymorphism in P-selectin glycoprotein ligand (PSGL-1) with carotid plaque presence: preliminary study VL - 39 IS - 6 SP - 6479 EP - 6485 DO - 10.1007/s11033-012-1475-5 ER -
@article{ author = "Živković, Maja and Kolaković, Ana and Radak, Đorđe J. and Dinčić, Dragan and Radak, Sandra and Đurić, Tamara and Stanković, Aleksandra", year = "2012", abstract = "Atherosclerosis is known as an inflammatory disease in which a recruitment of leukocytes to the endothelium wall represents a preliminary step of the initiation and the development of disease. The P-selectin glycoprotein ligand (PSGL-1) seems to be the major molecule mediating leukocyte-endothelium interactions and leukocyte rolling on stimulated endothelium. There are limited number of studies reporting on association of Met62Ile SNP in PSGL-1 gene and the risk for atherosclerosis. The aim of this study was to analyze possible association of this polymorphism with an advanced carotid atherosclerosis and biochemical markers of inflammation and haemostasis. The 275 patients consecutively admitted for carotid endarterectomy with stenosis GT 70% and 256 controls of the same ethnic origin were included in the study. The Met62Ile genotypes were determined by PCR RFLP. The Ile/Ile homozygotes had significantly higher CRP compared to the other genotypes in patients. Female patients had Ile allele dose-dependent association with the carotid plaque presence (Met/Met vs. Met/Ile vs. Ile/Ile; OR 1, OR 2.02, CI 1.0-4.08, OR 4.08, CI 1.0-16.81, respectively, p = 0.04). Our results suggest the impact of PSGL-1 Met62Ile polymorphism on inflammation in advanced atherosclerosis. We observed the sex-differential association of Met62Ile with advanced carotid atherosclerosis. Studies in larger and different populations should validate and further examine the suggested role of genetic variations in PSGL-1 with atherosclerosis and thrombosis.", journal = "Molecular Biology Reports", title = "The sex-specific association of Met62Ile gene polymorphism in P-selectin glycoprotein ligand (PSGL-1) with carotid plaque presence: preliminary study", volume = "39", number = "6", pages = "6479-6485", doi = "10.1007/s11033-012-1475-5" }
Živković, M., Kolaković, A., Radak, Đ. J., Dinčić, D., Radak, S., Đurić, T.,& Stanković, A.. (2012). The sex-specific association of Met62Ile gene polymorphism in P-selectin glycoprotein ligand (PSGL-1) with carotid plaque presence: preliminary study. in Molecular Biology Reports, 39(6), 6479-6485. https://doi.org/10.1007/s11033-012-1475-5
Živković M, Kolaković A, Radak ĐJ, Dinčić D, Radak S, Đurić T, Stanković A. The sex-specific association of Met62Ile gene polymorphism in P-selectin glycoprotein ligand (PSGL-1) with carotid plaque presence: preliminary study. in Molecular Biology Reports. 2012;39(6):6479-6485. doi:10.1007/s11033-012-1475-5 .
Živković, Maja, Kolaković, Ana, Radak, Đorđe J., Dinčić, Dragan, Radak, Sandra, Đurić, Tamara, Stanković, Aleksandra, "The sex-specific association of Met62Ile gene polymorphism in P-selectin glycoprotein ligand (PSGL-1) with carotid plaque presence: preliminary study" in Molecular Biology Reports, 39, no. 6 (2012):6479-6485, https://doi.org/10.1007/s11033-012-1475-5 . .