In silico analysis suggests interaction between Ebola virus and the extracellular matrix
Autori
Veljković, VeljkoGlišić, Sanja
Muller, Claude P.
Scotch, Matthew
Branch, Donald R.
Perović, Vladimir R.
Senćanski, Milan V.
Veljković, Nevena V.
Colombatti, Alfonso
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
The worst Ebola virus (EV) outbreak in history has hit Liberia, Sierra Leone and Guinea hardest and the trend lines in this crisis are grave, and now represents a global public health threat concern. Limited therapeutic and/or prophylactic options are available for people suffering from Ebola virus disease (EVD) and further complicate the situation. Previous studies suggested that the EV glycoprotein (GP) is the main determinant causing structural damage of endothelial cells that triggers the hemorrhagic diathesis, but molecular mechanisms underlying this phenomenon remains elusive. Using the informational spectrum method (ISM), a virtual spectroscopy method for analysis of the protein-protein interactions, the interaction of GP with endothelial extracellular matrix (ECM) was investigated. Presented results of this in silico study suggest that Elastin Microfibril Interface Located Proteins (EMILINs) are involved in interaction between GP and ECM. This finding could contribute to a bett...er understanding of EV/endothelium interaction and its role in pathogenesis, prevention and therapy of EVD.
Ključne reči:
Ebola virus / glycoprotein GP / endothelial extracellular matrix / EMILINs / in silico analysisIzvor:
Frontiers in Microbiology, 2015, 6Finansiranje / projekti:
- Primena EIIP/ISM bioinformatičke platforme u otkrivanju novih terapeutskih targeta i potencijalnih terapeutskih molekula (RS-MESTD-Basic Research (BR or ON)-173001)
DOI: 10.3389/fmicb.2015.00135
ISSN: 1664-302X
PubMed: 25745423
WoS: 000350310200001
Scopus: 2-s2.0-84927523630
Kolekcije
Institucija/grupa
VinčaTY - JOUR AU - Veljković, Veljko AU - Glišić, Sanja AU - Muller, Claude P. AU - Scotch, Matthew AU - Branch, Donald R. AU - Perović, Vladimir R. AU - Senćanski, Milan V. AU - Veljković, Nevena V. AU - Colombatti, Alfonso PY - 2015 UR - https://vinar.vin.bg.ac.rs/handle/123456789/423 AB - The worst Ebola virus (EV) outbreak in history has hit Liberia, Sierra Leone and Guinea hardest and the trend lines in this crisis are grave, and now represents a global public health threat concern. Limited therapeutic and/or prophylactic options are available for people suffering from Ebola virus disease (EVD) and further complicate the situation. Previous studies suggested that the EV glycoprotein (GP) is the main determinant causing structural damage of endothelial cells that triggers the hemorrhagic diathesis, but molecular mechanisms underlying this phenomenon remains elusive. Using the informational spectrum method (ISM), a virtual spectroscopy method for analysis of the protein-protein interactions, the interaction of GP with endothelial extracellular matrix (ECM) was investigated. Presented results of this in silico study suggest that Elastin Microfibril Interface Located Proteins (EMILINs) are involved in interaction between GP and ECM. This finding could contribute to a better understanding of EV/endothelium interaction and its role in pathogenesis, prevention and therapy of EVD. T2 - Frontiers in Microbiology T1 - In silico analysis suggests interaction between Ebola virus and the extracellular matrix VL - 6 DO - 10.3389/fmicb.2015.00135 ER -
@article{ author = "Veljković, Veljko and Glišić, Sanja and Muller, Claude P. and Scotch, Matthew and Branch, Donald R. and Perović, Vladimir R. and Senćanski, Milan V. and Veljković, Nevena V. and Colombatti, Alfonso", year = "2015", abstract = "The worst Ebola virus (EV) outbreak in history has hit Liberia, Sierra Leone and Guinea hardest and the trend lines in this crisis are grave, and now represents a global public health threat concern. Limited therapeutic and/or prophylactic options are available for people suffering from Ebola virus disease (EVD) and further complicate the situation. Previous studies suggested that the EV glycoprotein (GP) is the main determinant causing structural damage of endothelial cells that triggers the hemorrhagic diathesis, but molecular mechanisms underlying this phenomenon remains elusive. Using the informational spectrum method (ISM), a virtual spectroscopy method for analysis of the protein-protein interactions, the interaction of GP with endothelial extracellular matrix (ECM) was investigated. Presented results of this in silico study suggest that Elastin Microfibril Interface Located Proteins (EMILINs) are involved in interaction between GP and ECM. This finding could contribute to a better understanding of EV/endothelium interaction and its role in pathogenesis, prevention and therapy of EVD.", journal = "Frontiers in Microbiology", title = "In silico analysis suggests interaction between Ebola virus and the extracellular matrix", volume = "6", doi = "10.3389/fmicb.2015.00135" }
Veljković, V., Glišić, S., Muller, C. P., Scotch, M., Branch, D. R., Perović, V. R., Senćanski, M. V., Veljković, N. V.,& Colombatti, A.. (2015). In silico analysis suggests interaction between Ebola virus and the extracellular matrix. in Frontiers in Microbiology, 6. https://doi.org/10.3389/fmicb.2015.00135
Veljković V, Glišić S, Muller CP, Scotch M, Branch DR, Perović VR, Senćanski MV, Veljković NV, Colombatti A. In silico analysis suggests interaction between Ebola virus and the extracellular matrix. in Frontiers in Microbiology. 2015;6. doi:10.3389/fmicb.2015.00135 .
Veljković, Veljko, Glišić, Sanja, Muller, Claude P., Scotch, Matthew, Branch, Donald R., Perović, Vladimir R., Senćanski, Milan V., Veljković, Nevena V., Colombatti, Alfonso, "In silico analysis suggests interaction between Ebola virus and the extracellular matrix" in Frontiers in Microbiology, 6 (2015), https://doi.org/10.3389/fmicb.2015.00135 . .