Lithium Modulates the Chronic Stress-Induced Effect on Blood Glucose Level of Male Rats
Apstrakt
In the present study we examined gross changes in the mass of whole adrenal glands and that of the adrenal cortex, as well as the serum corticosterone and glucose level of mature male Wistar rats subjected to three different treatments: animals subjected to chronic restraint-stress, animals injected with lithium (Li) and chronically stressed rats treated with Li. Under all three conditions we observed hypertrophy of whole adrenals, as well as the adrenal cortices. Chronic restraint stress, solely or in combination with Li treatment, significantly elevated the corticosterone level, but did not change the blood glucose level. Animals treated only with Li exhibited an elevated serum corticosterone level and blood glucose level. The aim of our study was to investigate the modulation of the chronic stress-induced effect on the blood glucose level by lithium, as a possible mechanism of avoiding the damage caused by chronic stress. Our results showed that lithium is an agent of choice which m...ay help to reduce stress-elevated corticosterone and replenish exhausted glucose storages in an organism.
Ključne reči:
Wistar rats / lithium / restraint stress / adrenal glands / corticosterone / glucoseIzvor:
Archives of Biological Sciences, 2010, 62, 2, 289-295Finansiranje / projekti:
- Signalni putevi delovanja steroidnih hormona i uticaj endogenih i egzogenih faktora na modulaciju procesa u ćelijama sisara (RS-MESTD-MPN2006-2010-143044)
DOI: 10.2298/ABS1002289P
ISSN: 0354-4664
WoS: 000280017400011
Scopus: 2-s2.0-77955126849
Kolekcije
Institucija/grupa
VinčaTY - JOUR AU - Popović, Nataša M. AU - Pajović, Snežana B. PY - 2010 UR - https://vinar.vin.bg.ac.rs/handle/123456789/4048 AB - In the present study we examined gross changes in the mass of whole adrenal glands and that of the adrenal cortex, as well as the serum corticosterone and glucose level of mature male Wistar rats subjected to three different treatments: animals subjected to chronic restraint-stress, animals injected with lithium (Li) and chronically stressed rats treated with Li. Under all three conditions we observed hypertrophy of whole adrenals, as well as the adrenal cortices. Chronic restraint stress, solely or in combination with Li treatment, significantly elevated the corticosterone level, but did not change the blood glucose level. Animals treated only with Li exhibited an elevated serum corticosterone level and blood glucose level. The aim of our study was to investigate the modulation of the chronic stress-induced effect on the blood glucose level by lithium, as a possible mechanism of avoiding the damage caused by chronic stress. Our results showed that lithium is an agent of choice which may help to reduce stress-elevated corticosterone and replenish exhausted glucose storages in an organism. T2 - Archives of Biological Sciences T1 - Lithium Modulates the Chronic Stress-Induced Effect on Blood Glucose Level of Male Rats VL - 62 IS - 2 SP - 289 EP - 295 DO - 10.2298/ABS1002289P ER -
@article{ author = "Popović, Nataša M. and Pajović, Snežana B.", year = "2010", abstract = "In the present study we examined gross changes in the mass of whole adrenal glands and that of the adrenal cortex, as well as the serum corticosterone and glucose level of mature male Wistar rats subjected to three different treatments: animals subjected to chronic restraint-stress, animals injected with lithium (Li) and chronically stressed rats treated with Li. Under all three conditions we observed hypertrophy of whole adrenals, as well as the adrenal cortices. Chronic restraint stress, solely or in combination with Li treatment, significantly elevated the corticosterone level, but did not change the blood glucose level. Animals treated only with Li exhibited an elevated serum corticosterone level and blood glucose level. The aim of our study was to investigate the modulation of the chronic stress-induced effect on the blood glucose level by lithium, as a possible mechanism of avoiding the damage caused by chronic stress. Our results showed that lithium is an agent of choice which may help to reduce stress-elevated corticosterone and replenish exhausted glucose storages in an organism.", journal = "Archives of Biological Sciences", title = "Lithium Modulates the Chronic Stress-Induced Effect on Blood Glucose Level of Male Rats", volume = "62", number = "2", pages = "289-295", doi = "10.2298/ABS1002289P" }
Popović, N. M.,& Pajović, S. B.. (2010). Lithium Modulates the Chronic Stress-Induced Effect on Blood Glucose Level of Male Rats. in Archives of Biological Sciences, 62(2), 289-295. https://doi.org/10.2298/ABS1002289P
Popović NM, Pajović SB. Lithium Modulates the Chronic Stress-Induced Effect on Blood Glucose Level of Male Rats. in Archives of Biological Sciences. 2010;62(2):289-295. doi:10.2298/ABS1002289P .
Popović, Nataša M., Pajović, Snežana B., "Lithium Modulates the Chronic Stress-Induced Effect on Blood Glucose Level of Male Rats" in Archives of Biological Sciences, 62, no. 2 (2010):289-295, https://doi.org/10.2298/ABS1002289P . .