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Protective Effect on Human Lymphocytes of Some Flavonoids Isolated from Two Achillea Species
dc.creator | Aljancic, Ivana | |
dc.creator | Stanković, Miroslava | |
dc.creator | Tešević, Vele V. | |
dc.creator | Vujisić, Ljubodrag | |
dc.creator | Vajs, Vlatka | |
dc.creator | Milosavljević, Slobodan | |
dc.date.accessioned | 2018-03-01T21:13:40Z | |
dc.date.available | 2018-03-01T21:13:40Z | |
dc.date.issued | 2010 | |
dc.identifier.issn | 1934-578X | |
dc.identifier.uri | https://vinar.vin.bg.ac.rs/handle/123456789/4002 | |
dc.description.abstract | This study was conducted to elucidate the in vitro protective effect of five flavonoids [apigenin (1), apigenin-7-O-glucoside (2), centaureidin (3), jaceidin (4) and quercetin (5)] against chromosomal damage in mitogen-induced human lymphocytes. Using the Cytochalasin-B blocked micronucleus (CBMN) assay, in which the biomarker of chromosome breakage and/or chromosome loss is the elevated frequency of micronucleus (MN) in binucleated (BN) cells, the presence of flavonoid 2 in minimal concentration (3 mu g/mL) gave a 35.5% decrease M the frequency of MN when compared with control human lymphocytes. The same concentration of flavonoids 1, 3 and 4, reduced the MN frequency by 24.4%, 28.0% and 28.0%, respectively. Higher concentrations (6 mu g/mL and 10 mu g/mL) seemed less effective. Flavonoid 5 (3 mu g/mL.) induced a slight decrease in MN frequency (5%), while higher doses (6 mu g/mL and 10 mu g/mL) provoked an increase of DNA damage. The comparable values for the cytokinesis-block proliferation index (CBPI) of the tested flavonoids and positive control suggested an inhibitory effect on lymphocyte proliferation. In the DPPH scavenging assay, flavonoids 1-4 demonstrated modest activity, in a dose-dependent manner, compared with the synthetic antioxidants BHT and Trolox, while 5 exhibited comparably high antioxidative activity. | en |
dc.relation | Ministry of Sciences and Technological Development of the Republic of Serbia [142053] | |
dc.rights | restrictedAccess | en |
dc.source | Natural Product Communications | en |
dc.subject | Flavonoids | en |
dc.subject | CBMN | en |
dc.subject | DPPH | en |
dc.subject | BHT | en |
dc.title | Protective Effect on Human Lymphocytes of Some Flavonoids Isolated from Two Achillea Species | en |
dc.type | article | en |
dcterms.abstract | Станковиц, Мирослава; Милосављевиц, Слободан; Aљанциц, Ивана; Вајс, Влатка; Тесевиц, Веле; Вујисиц, Љубодраг; | |
dc.citation.volume | 5 | |
dc.citation.issue | 5 | |
dc.citation.spage | 729 | |
dc.citation.epage | 732 | |
dc.identifier.wos | 000277750200012 | |
dc.citation.rank | M23 | |
dc.identifier.pmid | 20521537 | |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_vinar_4002 |
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