Influence of ultrasonic processing on the macromolecular properties of poly (D,L-lactide-co-glycolide) alone and in its biocomposite with hydroxyapatite
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Vukomanovic, MarijaMitrić, Miodrag
Škapin, Srečo Davor
Zagar, Ema
Plavec, Janez
Ignjatović, Nenad L.
Uskoković, Dragan
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In this work poly(D,L-lactide-co-glycolide) (PLGA) and a poly(D,L-lactide-co-glycolide)/hydroxyapatite (PLGA/HAp) composite processed in an ultrasonic field at higher (25 degrees C) and lower (8 degrees C) temperatures were studied with respect to the molecular properties of the obtained materials. The processing of the PLGA and the PLGA/HAp composite in an ultrasonic field resulted in a change of molar mass averages of the polymer/polymeric part of these materials, while an amorphous structure and a 50:50 lactide-to-glycolide co-monomer ratio were preserved without the formation of crystalline oligomers. However, mobility of polymeric chains obtained after ultrasonic processing was lower indicating ordering the structure of polymeric chains as a result of processing. Additionally, it was observed that the mobility of the PLGA macromolecules was lower within the composite in comparison with the mobility of the chains within the PLGA alone in the case when both were obtained after ultra...sonic processing. This was a consequence of the structure formation through the interactions between the PLGA and the HAp. Based on these results different degradation rate of PLGA in composite can be expected, which is important in the application of this material for the controlled drug delivery of medicaments. (C) 2010 Elsevier B.V. All rights reserved.
Keywords:
Poly(D,L-lactide-co-glycolide) / Poly(D,L-lactide-co-glycolide)/hydroxyapatite composite / Molar mass averages / Composition / Glass-transition temperature / Ultrasonic processingSource:
Ultrasonics Sonochemistry, 2010, 17, 5, 902-908Funding / projects:
- Sinteza funkcionalnih materijala sa kontrolisanom strukturom na molekularnom i nano nivou (RS-MESTD-MPN2006-2010-142006)
DOI: 10.1016/j.ultsonch.2010.01.007
ISSN: 1350-4177; 1873-2828
PubMed: 20163978
WoS: 000278297400027
Scopus: 2-s2.0-77953650673
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VinčaTY - JOUR AU - Vukomanovic, Marija AU - Mitrić, Miodrag AU - Škapin, Srečo Davor AU - Zagar, Ema AU - Plavec, Janez AU - Ignjatović, Nenad L. AU - Uskoković, Dragan PY - 2010 UR - https://vinar.vin.bg.ac.rs/handle/123456789/3943 AB - In this work poly(D,L-lactide-co-glycolide) (PLGA) and a poly(D,L-lactide-co-glycolide)/hydroxyapatite (PLGA/HAp) composite processed in an ultrasonic field at higher (25 degrees C) and lower (8 degrees C) temperatures were studied with respect to the molecular properties of the obtained materials. The processing of the PLGA and the PLGA/HAp composite in an ultrasonic field resulted in a change of molar mass averages of the polymer/polymeric part of these materials, while an amorphous structure and a 50:50 lactide-to-glycolide co-monomer ratio were preserved without the formation of crystalline oligomers. However, mobility of polymeric chains obtained after ultrasonic processing was lower indicating ordering the structure of polymeric chains as a result of processing. Additionally, it was observed that the mobility of the PLGA macromolecules was lower within the composite in comparison with the mobility of the chains within the PLGA alone in the case when both were obtained after ultrasonic processing. This was a consequence of the structure formation through the interactions between the PLGA and the HAp. Based on these results different degradation rate of PLGA in composite can be expected, which is important in the application of this material for the controlled drug delivery of medicaments. (C) 2010 Elsevier B.V. All rights reserved. T2 - Ultrasonics Sonochemistry T1 - Influence of ultrasonic processing on the macromolecular properties of poly (D,L-lactide-co-glycolide) alone and in its biocomposite with hydroxyapatite VL - 17 IS - 5 SP - 902 EP - 908 DO - 10.1016/j.ultsonch.2010.01.007 ER -
@article{ author = "Vukomanovic, Marija and Mitrić, Miodrag and Škapin, Srečo Davor and Zagar, Ema and Plavec, Janez and Ignjatović, Nenad L. and Uskoković, Dragan", year = "2010", abstract = "In this work poly(D,L-lactide-co-glycolide) (PLGA) and a poly(D,L-lactide-co-glycolide)/hydroxyapatite (PLGA/HAp) composite processed in an ultrasonic field at higher (25 degrees C) and lower (8 degrees C) temperatures were studied with respect to the molecular properties of the obtained materials. The processing of the PLGA and the PLGA/HAp composite in an ultrasonic field resulted in a change of molar mass averages of the polymer/polymeric part of these materials, while an amorphous structure and a 50:50 lactide-to-glycolide co-monomer ratio were preserved without the formation of crystalline oligomers. However, mobility of polymeric chains obtained after ultrasonic processing was lower indicating ordering the structure of polymeric chains as a result of processing. Additionally, it was observed that the mobility of the PLGA macromolecules was lower within the composite in comparison with the mobility of the chains within the PLGA alone in the case when both were obtained after ultrasonic processing. This was a consequence of the structure formation through the interactions between the PLGA and the HAp. Based on these results different degradation rate of PLGA in composite can be expected, which is important in the application of this material for the controlled drug delivery of medicaments. (C) 2010 Elsevier B.V. All rights reserved.", journal = "Ultrasonics Sonochemistry", title = "Influence of ultrasonic processing on the macromolecular properties of poly (D,L-lactide-co-glycolide) alone and in its biocomposite with hydroxyapatite", volume = "17", number = "5", pages = "902-908", doi = "10.1016/j.ultsonch.2010.01.007" }
Vukomanovic, M., Mitrić, M., Škapin, S. D., Zagar, E., Plavec, J., Ignjatović, N. L.,& Uskoković, D.. (2010). Influence of ultrasonic processing on the macromolecular properties of poly (D,L-lactide-co-glycolide) alone and in its biocomposite with hydroxyapatite. in Ultrasonics Sonochemistry, 17(5), 902-908. https://doi.org/10.1016/j.ultsonch.2010.01.007
Vukomanovic M, Mitrić M, Škapin SD, Zagar E, Plavec J, Ignjatović NL, Uskoković D. Influence of ultrasonic processing on the macromolecular properties of poly (D,L-lactide-co-glycolide) alone and in its biocomposite with hydroxyapatite. in Ultrasonics Sonochemistry. 2010;17(5):902-908. doi:10.1016/j.ultsonch.2010.01.007 .
Vukomanovic, Marija, Mitrić, Miodrag, Škapin, Srečo Davor, Zagar, Ema, Plavec, Janez, Ignjatović, Nenad L., Uskoković, Dragan, "Influence of ultrasonic processing on the macromolecular properties of poly (D,L-lactide-co-glycolide) alone and in its biocomposite with hydroxyapatite" in Ultrasonics Sonochemistry, 17, no. 5 (2010):902-908, https://doi.org/10.1016/j.ultsonch.2010.01.007 . .