Clinical investigations of Tc-99m-p-aminohippuric acid as a new renal agent
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Jaksic, EmilijaArtiko, Vera
Beatovic, Slobodanka
Đokić, Divna Đ.
Janković, Drina
Saranovic, Dragana Sobic
Han, Ruben
Obradović, Vladimir
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Objective Tc-99m-p-aminohippuric acid (PAH) is a new radiopharmaceutical rapidly secreted by the kidneys in a manner consistent with tubular secretion. A comparative study of renal scintigraphy and clearance with Tc-99m-PAH, diethylene triamine pentaacetic acid (DTPA) and mercaptoacetyltriglycine (MAG(3)) was performed. Methods (TC)-T-99m-PAH was prepared from a lyophilized kit by addition of sodium pertechnetate in the presence of DTPA. Ten healthy individuals were injected with 110 MBq of Tc-99m-PAH. A dynamic study was repeated with Tc-99m-DTPA and Tc-99m-MAG(3) several days later, after a 1-day interval. Clearance measurements were performed in five individuals. Results The mean values of time-to-peak activity (T-max) and the time from peak to 50% of peak activity (T-1/2) for Tc-99m-PAH (3.6 +/- 0.9 and 6.9 +/- 2.7 min, respectively) and Tc-99m-MAG, (3.5 +/- 0.8 and 6.8 +/- 2.1 respectively) were significantly lower in comparison with those of Tc-99m-DTPA (4.9 +/- 1.7 and 11.7 +/- ...1.9 min, respectively). The mean value of Tc-99m-PAH clearance (186.9 +/- 12.2 ml/min) was significantly lower in comparison with MAG(3) clearance (303.9 +/- 19.5 ml/min) and significantly higher than DTPA clearance (85.0 +/- 24.1 ml/min). Conclusion Our preliminary results indicate the potential usefulness of Tc-99m-PAH for routine renal scintigraphy. Owing to its fast kinetics, excretion and high-quality images, it could be a suitable for Tc-99m-DTPA. Tc-99m-PAH clearance values, however, were significantly lower than those of MAG(3), and could not be used for the estimation of renal plasma flow. Nucl Med Commun 30:76-81 (C) 2009 Wolters Kluwer Health vertical bar Lippincott Williams and Wilkins.
Keywords:
radiopharmaceuticals / renal imaging / technetium-99m p-aminohippuric acidSource:
Nuclear Medicine Communications, 2009, 30, 1, 76-81Funding / projects:
- Ministry of Science Republic of Serbia [145303]
DOI: 10.1097/MNM.0b013e328314b8bc
ISSN: 0143-3636
PubMed: 19306517
WoS: 000262060200012
Scopus: 2-s2.0-57749196433
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VinčaTY - JOUR AU - Jaksic, Emilija AU - Artiko, Vera AU - Beatovic, Slobodanka AU - Đokić, Divna Đ. AU - Janković, Drina AU - Saranovic, Dragana Sobic AU - Han, Ruben AU - Obradović, Vladimir PY - 2009 UR - https://vinar.vin.bg.ac.rs/handle/123456789/3605 AB - Objective Tc-99m-p-aminohippuric acid (PAH) is a new radiopharmaceutical rapidly secreted by the kidneys in a manner consistent with tubular secretion. A comparative study of renal scintigraphy and clearance with Tc-99m-PAH, diethylene triamine pentaacetic acid (DTPA) and mercaptoacetyltriglycine (MAG(3)) was performed. Methods (TC)-T-99m-PAH was prepared from a lyophilized kit by addition of sodium pertechnetate in the presence of DTPA. Ten healthy individuals were injected with 110 MBq of Tc-99m-PAH. A dynamic study was repeated with Tc-99m-DTPA and Tc-99m-MAG(3) several days later, after a 1-day interval. Clearance measurements were performed in five individuals. Results The mean values of time-to-peak activity (T-max) and the time from peak to 50% of peak activity (T-1/2) for Tc-99m-PAH (3.6 +/- 0.9 and 6.9 +/- 2.7 min, respectively) and Tc-99m-MAG, (3.5 +/- 0.8 and 6.8 +/- 2.1 respectively) were significantly lower in comparison with those of Tc-99m-DTPA (4.9 +/- 1.7 and 11.7 +/- 1.9 min, respectively). The mean value of Tc-99m-PAH clearance (186.9 +/- 12.2 ml/min) was significantly lower in comparison with MAG(3) clearance (303.9 +/- 19.5 ml/min) and significantly higher than DTPA clearance (85.0 +/- 24.1 ml/min). Conclusion Our preliminary results indicate the potential usefulness of Tc-99m-PAH for routine renal scintigraphy. Owing to its fast kinetics, excretion and high-quality images, it could be a suitable for Tc-99m-DTPA. Tc-99m-PAH clearance values, however, were significantly lower than those of MAG(3), and could not be used for the estimation of renal plasma flow. Nucl Med Commun 30:76-81 (C) 2009 Wolters Kluwer Health vertical bar Lippincott Williams and Wilkins. T2 - Nuclear Medicine Communications T1 - Clinical investigations of Tc-99m-p-aminohippuric acid as a new renal agent VL - 30 IS - 1 SP - 76 EP - 81 DO - 10.1097/MNM.0b013e328314b8bc ER -
@article{ author = "Jaksic, Emilija and Artiko, Vera and Beatovic, Slobodanka and Đokić, Divna Đ. and Janković, Drina and Saranovic, Dragana Sobic and Han, Ruben and Obradović, Vladimir", year = "2009", abstract = "Objective Tc-99m-p-aminohippuric acid (PAH) is a new radiopharmaceutical rapidly secreted by the kidneys in a manner consistent with tubular secretion. A comparative study of renal scintigraphy and clearance with Tc-99m-PAH, diethylene triamine pentaacetic acid (DTPA) and mercaptoacetyltriglycine (MAG(3)) was performed. Methods (TC)-T-99m-PAH was prepared from a lyophilized kit by addition of sodium pertechnetate in the presence of DTPA. Ten healthy individuals were injected with 110 MBq of Tc-99m-PAH. A dynamic study was repeated with Tc-99m-DTPA and Tc-99m-MAG(3) several days later, after a 1-day interval. Clearance measurements were performed in five individuals. Results The mean values of time-to-peak activity (T-max) and the time from peak to 50% of peak activity (T-1/2) for Tc-99m-PAH (3.6 +/- 0.9 and 6.9 +/- 2.7 min, respectively) and Tc-99m-MAG, (3.5 +/- 0.8 and 6.8 +/- 2.1 respectively) were significantly lower in comparison with those of Tc-99m-DTPA (4.9 +/- 1.7 and 11.7 +/- 1.9 min, respectively). The mean value of Tc-99m-PAH clearance (186.9 +/- 12.2 ml/min) was significantly lower in comparison with MAG(3) clearance (303.9 +/- 19.5 ml/min) and significantly higher than DTPA clearance (85.0 +/- 24.1 ml/min). Conclusion Our preliminary results indicate the potential usefulness of Tc-99m-PAH for routine renal scintigraphy. Owing to its fast kinetics, excretion and high-quality images, it could be a suitable for Tc-99m-DTPA. Tc-99m-PAH clearance values, however, were significantly lower than those of MAG(3), and could not be used for the estimation of renal plasma flow. Nucl Med Commun 30:76-81 (C) 2009 Wolters Kluwer Health vertical bar Lippincott Williams and Wilkins.", journal = "Nuclear Medicine Communications", title = "Clinical investigations of Tc-99m-p-aminohippuric acid as a new renal agent", volume = "30", number = "1", pages = "76-81", doi = "10.1097/MNM.0b013e328314b8bc" }
Jaksic, E., Artiko, V., Beatovic, S., Đokić, D. Đ., Janković, D., Saranovic, D. S., Han, R.,& Obradović, V.. (2009). Clinical investigations of Tc-99m-p-aminohippuric acid as a new renal agent. in Nuclear Medicine Communications, 30(1), 76-81. https://doi.org/10.1097/MNM.0b013e328314b8bc
Jaksic E, Artiko V, Beatovic S, Đokić DĐ, Janković D, Saranovic DS, Han R, Obradović V. Clinical investigations of Tc-99m-p-aminohippuric acid as a new renal agent. in Nuclear Medicine Communications. 2009;30(1):76-81. doi:10.1097/MNM.0b013e328314b8bc .
Jaksic, Emilija, Artiko, Vera, Beatovic, Slobodanka, Đokić, Divna Đ., Janković, Drina, Saranovic, Dragana Sobic, Han, Ruben, Obradović, Vladimir, "Clinical investigations of Tc-99m-p-aminohippuric acid as a new renal agent" in Nuclear Medicine Communications, 30, no. 1 (2009):76-81, https://doi.org/10.1097/MNM.0b013e328314b8bc . .