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Regulation of the inducible nitric oxide synthase and sodium pump in type 1 diabetes
dc.creator | Žakula, Zorica | |
dc.creator | Korićanac, Goran | |
dc.creator | Putniković, Biljana | |
dc.creator | Markovic, Ljiljana | |
dc.creator | Isenović, Esma R. | |
dc.date.accessioned | 2018-03-01T20:05:02Z | |
dc.date.available | 2018-03-01T20:05:02Z | |
dc.date.issued | 2007 | |
dc.identifier.issn | 0306-9877 | |
dc.identifier.uri | https://vinar.vin.bg.ac.rs/handle/123456789/3205 | |
dc.description.abstract | Insulin-like growth factor-1 (IGF-1) is a hormone and growth factor closely related to insulin. The autocrine/paracrine actions of IGF-1 involve activation of inducible nitric oxide synthase (iNOS) and the Na(+), K(+)-ATPase sodium pump in cardiovascular tissues. Data from literature indicate that iNOS is expressed in vascular smooth muscle cells (VSMC) and that IGF- 1 -induced release of NO is both rapid and delayed. We hypothesize that impaired IGF-1 -induced sodium pump activity/ expression in rats with type 1 diabetes is related to activation of phosphatidytinositol 3 kinase (PI3K)/cytosolic phospholipase 2 (cPLA(2))/protein kinase B (Akt) signaling, and that IGF-1 prevents acute and chronic dysfunction of iNOS and sodium pump activity in a chemically induced model of type 1 diabetes, the streptozotocin -treated rat heart (STZ). Understanding how iNOS and sodium pump activity are regulated by IGF-1 activation of the PI3K/cPLA(2)/Akt cascade should provide novel and fundamental knowledge regarding the regulatory actions of IGF-1 in promoting vasodilation. Since insulin resistance is currently a major focus of research, the use of IGF-1 to improve insulin resistance and glucose metabolism has opened a new arena for treatment of comorbid conditions. Future investigations should now focus on mechanisms of action of IGF-1 and its clinical applicability. (c) 2007 Elsevier Ltd. All rights reserved. | en |
dc.rights | restrictedAccess | en |
dc.source | Medical Hypotheses | en |
dc.title | Regulation of the inducible nitric oxide synthase and sodium pump in type 1 diabetes | en |
dc.type | article | en |
dcterms.abstract | Закула, Зорица; Путниковиц, Биљана; Марковиц, Љиљана; Корићанац Горан; Исеновић Есма; | |
dc.citation.volume | 69 | |
dc.citation.issue | 2 | |
dc.citation.spage | 302 | |
dc.citation.epage | 306 | |
dc.identifier.wos | 000247683800012 | |
dc.identifier.doi | 10.1016/j.mehy.2006.11.045 | |
dc.citation.rank | M23 | |
dc.identifier.pmid | 17289286 | |
dc.identifier.scopus | 2-s2.0-34249730961 |
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