Biocompatible and bioadhesive hydrogels based on 2-hydroxyethyl methacrylate, monofunctional poly(alkylene glycol)s and itaconic acid
Апстракт
Novel poly(Bisomer/HEMA/IA) hydrogels were prepared by radical copolymerization of poly(alkylene glycol) (meth)acrylates, i.e. short chains Bisomers, 2-hydroxyethyl methacrylate (HEMA) and itaconic acid (IA) in a mixture of water/ethanol as solvent. These hydrogels were characterized in terms of swelling in conditions similar to the biological fluids (pH range 2.20-7.40 buffer solutions), compression-strain measurements, thermal properties and morphology. The influence of the type of Bisomer and of the itaconic acid on swelling and mechanical properties, as well as on morphology and thermal behavior of the resulting hydrogels, were investigated. The in vitro study of biocompatibility, carried out with the hydrogels containing different types of Bisomers, showed no evidence of cell toxicity nor any considerable hemolytic activity. All hydrogels showed satisfactory bioadhesive properties, so these materials have potential as drug carriers or biological glue and sealants.
Кључне речи:
2-hydroxyethyl methacrylate / itaconic acid / poly(alkylene glycol) (meth)acrylates / hydrogels / physicochemical properties / biological evaluationИзвор:
Polymer Bulletin, 2006, 57, 5, 691-702
DOI: 10.1007/s00289-006-0606-3
ISSN: 0170-0839
WoS: 000240019500009
Scopus: 2-s2.0-33747641583
Колекције
Институција/група
VinčaTY - JOUR AU - Tomić, Simonida Lj. AU - Suljovrujić, Edin H. AU - Filipović, Jovanka M. PY - 2006 UR - https://vinar.vin.bg.ac.rs/handle/123456789/3073 AB - Novel poly(Bisomer/HEMA/IA) hydrogels were prepared by radical copolymerization of poly(alkylene glycol) (meth)acrylates, i.e. short chains Bisomers, 2-hydroxyethyl methacrylate (HEMA) and itaconic acid (IA) in a mixture of water/ethanol as solvent. These hydrogels were characterized in terms of swelling in conditions similar to the biological fluids (pH range 2.20-7.40 buffer solutions), compression-strain measurements, thermal properties and morphology. The influence of the type of Bisomer and of the itaconic acid on swelling and mechanical properties, as well as on morphology and thermal behavior of the resulting hydrogels, were investigated. The in vitro study of biocompatibility, carried out with the hydrogels containing different types of Bisomers, showed no evidence of cell toxicity nor any considerable hemolytic activity. All hydrogels showed satisfactory bioadhesive properties, so these materials have potential as drug carriers or biological glue and sealants. T2 - Polymer Bulletin T1 - Biocompatible and bioadhesive hydrogels based on 2-hydroxyethyl methacrylate, monofunctional poly(alkylene glycol)s and itaconic acid VL - 57 IS - 5 SP - 691 EP - 702 DO - 10.1007/s00289-006-0606-3 ER -
@article{ author = "Tomić, Simonida Lj. and Suljovrujić, Edin H. and Filipović, Jovanka M.", year = "2006", abstract = "Novel poly(Bisomer/HEMA/IA) hydrogels were prepared by radical copolymerization of poly(alkylene glycol) (meth)acrylates, i.e. short chains Bisomers, 2-hydroxyethyl methacrylate (HEMA) and itaconic acid (IA) in a mixture of water/ethanol as solvent. These hydrogels were characterized in terms of swelling in conditions similar to the biological fluids (pH range 2.20-7.40 buffer solutions), compression-strain measurements, thermal properties and morphology. The influence of the type of Bisomer and of the itaconic acid on swelling and mechanical properties, as well as on morphology and thermal behavior of the resulting hydrogels, were investigated. The in vitro study of biocompatibility, carried out with the hydrogels containing different types of Bisomers, showed no evidence of cell toxicity nor any considerable hemolytic activity. All hydrogels showed satisfactory bioadhesive properties, so these materials have potential as drug carriers or biological glue and sealants.", journal = "Polymer Bulletin", title = "Biocompatible and bioadhesive hydrogels based on 2-hydroxyethyl methacrylate, monofunctional poly(alkylene glycol)s and itaconic acid", volume = "57", number = "5", pages = "691-702", doi = "10.1007/s00289-006-0606-3" }
Tomić, S. Lj., Suljovrujić, E. H.,& Filipović, J. M.. (2006). Biocompatible and bioadhesive hydrogels based on 2-hydroxyethyl methacrylate, monofunctional poly(alkylene glycol)s and itaconic acid. in Polymer Bulletin, 57(5), 691-702. https://doi.org/10.1007/s00289-006-0606-3
Tomić SL, Suljovrujić EH, Filipović JM. Biocompatible and bioadhesive hydrogels based on 2-hydroxyethyl methacrylate, monofunctional poly(alkylene glycol)s and itaconic acid. in Polymer Bulletin. 2006;57(5):691-702. doi:10.1007/s00289-006-0606-3 .
Tomić, Simonida Lj., Suljovrujić, Edin H., Filipović, Jovanka M., "Biocompatible and bioadhesive hydrogels based on 2-hydroxyethyl methacrylate, monofunctional poly(alkylene glycol)s and itaconic acid" in Polymer Bulletin, 57, no. 5 (2006):691-702, https://doi.org/10.1007/s00289-006-0606-3 . .