Acid-base equilibria of 2,4-diiodo-6-methylphenylearbamoylmethyl iminodiacetic acid and its labeling with technetium-99m
Apstrakt
The acid-base equilibria of a novel hepatobiliary imaging agent, 2,4-diiodo-6-methylphenylcarbamoylmethyl iminodiacetic acid (DIIODIDA) were studied. The potentiometrically determined acidity constants of the second carboxylic group, amino and amide groups were pK(2) = 2.52 +/- 0.02; pK(3) = 5.86 +/- 0.06 and pK(4) = 10.9 +/- 0.1. The determinations were performed at 25 degrees C and an ionic strength of 0.1 mol/dm(3) (NaCl). The acidity constants (pK(1) = 1.3 +/- 0.4) corresponding to the first carboxylic group was determined indirectly, on the basis of equilibrium constants obtained in a heterogeneous system, at 25 degrees C and an ionic strength 1 mol/dm(3) (HCl, NaCl). DIIODIDA was labeled with teclinctiurn-99m, and the influence of pH on the yield of labeling was investigated. It was found that labeling within the pH range from 5.5 to 6.5 provided a radiopharmaceutical of high radiochemical purity ( GT 98%).
Ključne reči:
iminodiacetic acid analogues / acidity constants / hepatobiliary agent / technetium-99mIzvor:
Journal of the Serbian Chemical Society, 2006, 71, 1, 55-65
DOI: 10.2298/JSC0601055B
ISSN: 0352-5139
WoS: 000235562500006
Scopus: 2-s2.0-33644966489
Kolekcije
Institucija/grupa
VinčaTY - JOUR AU - Brborić, Jasmina AU - Jovanović, Moma S. AU - Popovic, G AU - Kapetanovic, V AU - Vladimirov, Sote PY - 2006 UR - https://vinar.vin.bg.ac.rs/handle/123456789/2981 AB - The acid-base equilibria of a novel hepatobiliary imaging agent, 2,4-diiodo-6-methylphenylcarbamoylmethyl iminodiacetic acid (DIIODIDA) were studied. The potentiometrically determined acidity constants of the second carboxylic group, amino and amide groups were pK(2) = 2.52 +/- 0.02; pK(3) = 5.86 +/- 0.06 and pK(4) = 10.9 +/- 0.1. The determinations were performed at 25 degrees C and an ionic strength of 0.1 mol/dm(3) (NaCl). The acidity constants (pK(1) = 1.3 +/- 0.4) corresponding to the first carboxylic group was determined indirectly, on the basis of equilibrium constants obtained in a heterogeneous system, at 25 degrees C and an ionic strength 1 mol/dm(3) (HCl, NaCl). DIIODIDA was labeled with teclinctiurn-99m, and the influence of pH on the yield of labeling was investigated. It was found that labeling within the pH range from 5.5 to 6.5 provided a radiopharmaceutical of high radiochemical purity ( GT 98%). T2 - Journal of the Serbian Chemical Society T1 - Acid-base equilibria of 2,4-diiodo-6-methylphenylearbamoylmethyl iminodiacetic acid and its labeling with technetium-99m VL - 71 IS - 1 SP - 55 EP - 65 DO - 10.2298/JSC0601055B ER -
@article{ author = "Brborić, Jasmina and Jovanović, Moma S. and Popovic, G and Kapetanovic, V and Vladimirov, Sote", year = "2006", abstract = "The acid-base equilibria of a novel hepatobiliary imaging agent, 2,4-diiodo-6-methylphenylcarbamoylmethyl iminodiacetic acid (DIIODIDA) were studied. The potentiometrically determined acidity constants of the second carboxylic group, amino and amide groups were pK(2) = 2.52 +/- 0.02; pK(3) = 5.86 +/- 0.06 and pK(4) = 10.9 +/- 0.1. The determinations were performed at 25 degrees C and an ionic strength of 0.1 mol/dm(3) (NaCl). The acidity constants (pK(1) = 1.3 +/- 0.4) corresponding to the first carboxylic group was determined indirectly, on the basis of equilibrium constants obtained in a heterogeneous system, at 25 degrees C and an ionic strength 1 mol/dm(3) (HCl, NaCl). DIIODIDA was labeled with teclinctiurn-99m, and the influence of pH on the yield of labeling was investigated. It was found that labeling within the pH range from 5.5 to 6.5 provided a radiopharmaceutical of high radiochemical purity ( GT 98%).", journal = "Journal of the Serbian Chemical Society", title = "Acid-base equilibria of 2,4-diiodo-6-methylphenylearbamoylmethyl iminodiacetic acid and its labeling with technetium-99m", volume = "71", number = "1", pages = "55-65", doi = "10.2298/JSC0601055B" }
Brborić, J., Jovanović, M. S., Popovic, G., Kapetanovic, V.,& Vladimirov, S.. (2006). Acid-base equilibria of 2,4-diiodo-6-methylphenylearbamoylmethyl iminodiacetic acid and its labeling with technetium-99m. in Journal of the Serbian Chemical Society, 71(1), 55-65. https://doi.org/10.2298/JSC0601055B
Brborić J, Jovanović MS, Popovic G, Kapetanovic V, Vladimirov S. Acid-base equilibria of 2,4-diiodo-6-methylphenylearbamoylmethyl iminodiacetic acid and its labeling with technetium-99m. in Journal of the Serbian Chemical Society. 2006;71(1):55-65. doi:10.2298/JSC0601055B .
Brborić, Jasmina, Jovanović, Moma S., Popovic, G, Kapetanovic, V, Vladimirov, Sote, "Acid-base equilibria of 2,4-diiodo-6-methylphenylearbamoylmethyl iminodiacetic acid and its labeling with technetium-99m" in Journal of the Serbian Chemical Society, 71, no. 1 (2006):55-65, https://doi.org/10.2298/JSC0601055B . .