Equilibrium sampling through membrane based on a single hollow fibre for determination of drug-protein binding and free drug concentration in plasma
Апстракт
The determination of drug-protein binding and free drug concentration in plasma applying the equilibrium sampling through membrane (ESTM) technique has been studied using supported liquid membrane extraction in a single hollow fibre without any membrane carrier. In the extraction setup, the donor phase (plasma or buffer) was placed in the vial, into which was immersed the hollow fibre with the acceptor phase situated in the lumen. This proposed technique was applied to study the drug-protein binding of five local anaesthetics and two antidepressants as model substances, and the influence of the total drug concentration on the drug-protein binding was investigated. The brief theoretical background for determination of the drug-protein binding under equilibrium conditions is described. The developed method shows a new, improved and simple procedure for determination of free drug concentration in plasma and extent of drug-protein binding. (c) 2005 Elsevier B.V. All rights reserved.
Кључне речи:
equilibrium sampling through membrane (ESTM) / hollow fibre / drug-protein binding / local anaesthetic / antidepressantИзвор:
Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 2005, 826, 1-2, 169-176
DOI: 10.1016/j.jchromb.2005.08.020
ISSN: 1570-0232
PubMed: 16181816
WoS: 000232872700022
Scopus: 2-s2.0-26844568469
Колекције
Институција/група
VinčaTY - JOUR AU - Trtić-Petrović, Tatjana M. AU - Liu, JF AU - Jonsson, JA PY - 2005 UR - https://vinar.vin.bg.ac.rs/handle/123456789/2940 AB - The determination of drug-protein binding and free drug concentration in plasma applying the equilibrium sampling through membrane (ESTM) technique has been studied using supported liquid membrane extraction in a single hollow fibre without any membrane carrier. In the extraction setup, the donor phase (plasma or buffer) was placed in the vial, into which was immersed the hollow fibre with the acceptor phase situated in the lumen. This proposed technique was applied to study the drug-protein binding of five local anaesthetics and two antidepressants as model substances, and the influence of the total drug concentration on the drug-protein binding was investigated. The brief theoretical background for determination of the drug-protein binding under equilibrium conditions is described. The developed method shows a new, improved and simple procedure for determination of free drug concentration in plasma and extent of drug-protein binding. (c) 2005 Elsevier B.V. All rights reserved. T2 - Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences T1 - Equilibrium sampling through membrane based on a single hollow fibre for determination of drug-protein binding and free drug concentration in plasma VL - 826 IS - 1-2 SP - 169 EP - 176 DO - 10.1016/j.jchromb.2005.08.020 ER -
@article{ author = "Trtić-Petrović, Tatjana M. and Liu, JF and Jonsson, JA", year = "2005", abstract = "The determination of drug-protein binding and free drug concentration in plasma applying the equilibrium sampling through membrane (ESTM) technique has been studied using supported liquid membrane extraction in a single hollow fibre without any membrane carrier. In the extraction setup, the donor phase (plasma or buffer) was placed in the vial, into which was immersed the hollow fibre with the acceptor phase situated in the lumen. This proposed technique was applied to study the drug-protein binding of five local anaesthetics and two antidepressants as model substances, and the influence of the total drug concentration on the drug-protein binding was investigated. The brief theoretical background for determination of the drug-protein binding under equilibrium conditions is described. The developed method shows a new, improved and simple procedure for determination of free drug concentration in plasma and extent of drug-protein binding. (c) 2005 Elsevier B.V. All rights reserved.", journal = "Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences", title = "Equilibrium sampling through membrane based on a single hollow fibre for determination of drug-protein binding and free drug concentration in plasma", volume = "826", number = "1-2", pages = "169-176", doi = "10.1016/j.jchromb.2005.08.020" }
Trtić-Petrović, T. M., Liu, J.,& Jonsson, J.. (2005). Equilibrium sampling through membrane based on a single hollow fibre for determination of drug-protein binding and free drug concentration in plasma. in Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 826(1-2), 169-176. https://doi.org/10.1016/j.jchromb.2005.08.020
Trtić-Petrović TM, Liu J, Jonsson J. Equilibrium sampling through membrane based on a single hollow fibre for determination of drug-protein binding and free drug concentration in plasma. in Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences. 2005;826(1-2):169-176. doi:10.1016/j.jchromb.2005.08.020 .
Trtić-Petrović, Tatjana M., Liu, JF, Jonsson, JA, "Equilibrium sampling through membrane based on a single hollow fibre for determination of drug-protein binding and free drug concentration in plasma" in Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 826, no. 1-2 (2005):169-176, https://doi.org/10.1016/j.jchromb.2005.08.020 . .