Angiotensin I-converting enzyme gene polymorphism in a Serbian population: a gender-specific association with hypertension
Апстракт
Human essential hypertension has a multifactorial origin and is caused by a delicate interaction between susceptibility genes and environmental factors. Candidate genes are selected from the renin-angiotensin system (RAS) and are physiologically implicated in blood pressure regulation. We investigated the association between insertion/deletion (I/D) polymorphism at the angiotensin-converting enzyme (ACE) locus and hypertension in a case-control study conducted in a population of Caucasians (175 females, 210 males). Case subjects were those with untreated borderline hypertension. A significant, moderate, male, gender-specific independent association between DD genotype and high blood pressure was found. Adjusted odds ratio (OR) was 2.0 (95% Cl, 1.1 to 3.9; p = 0.03) in the whole group and 2.5 (95% CL 1.2 to 5.1; p = 0.01) in the group truncated on the basis of age (less than or equal to 50 years). Our findings support the hypothesis that ACE is a gender-specific candidate gene for hyper...tension.
Кључне речи:
angiotensin / DNA polymorphism / gender / hypertension / populationИзвор:
Scandinavian Journal of Clinical and Laboratory Investigation, 2002, 62, 6, 469-475
DOI: 10.1080/00365510260390028
ISSN: 0036-5513
PubMed: 12469902
WoS: 000179228200008
Scopus: 2-s2.0-0036428807
Колекције
Институција/група
VinčaTY - JOUR AU - Stanković, Aleksandra AU - Živković, Maja AU - Alavantić, Dragan PY - 2002 UR - https://vinar.vin.bg.ac.rs/handle/123456789/2582 AB - Human essential hypertension has a multifactorial origin and is caused by a delicate interaction between susceptibility genes and environmental factors. Candidate genes are selected from the renin-angiotensin system (RAS) and are physiologically implicated in blood pressure regulation. We investigated the association between insertion/deletion (I/D) polymorphism at the angiotensin-converting enzyme (ACE) locus and hypertension in a case-control study conducted in a population of Caucasians (175 females, 210 males). Case subjects were those with untreated borderline hypertension. A significant, moderate, male, gender-specific independent association between DD genotype and high blood pressure was found. Adjusted odds ratio (OR) was 2.0 (95% Cl, 1.1 to 3.9; p = 0.03) in the whole group and 2.5 (95% CL 1.2 to 5.1; p = 0.01) in the group truncated on the basis of age (less than or equal to 50 years). Our findings support the hypothesis that ACE is a gender-specific candidate gene for hypertension. T2 - Scandinavian Journal of Clinical and Laboratory Investigation T1 - Angiotensin I-converting enzyme gene polymorphism in a Serbian population: a gender-specific association with hypertension VL - 62 IS - 6 SP - 469 EP - 475 DO - 10.1080/00365510260390028 ER -
@article{ author = "Stanković, Aleksandra and Živković, Maja and Alavantić, Dragan", year = "2002", abstract = "Human essential hypertension has a multifactorial origin and is caused by a delicate interaction between susceptibility genes and environmental factors. Candidate genes are selected from the renin-angiotensin system (RAS) and are physiologically implicated in blood pressure regulation. We investigated the association between insertion/deletion (I/D) polymorphism at the angiotensin-converting enzyme (ACE) locus and hypertension in a case-control study conducted in a population of Caucasians (175 females, 210 males). Case subjects were those with untreated borderline hypertension. A significant, moderate, male, gender-specific independent association between DD genotype and high blood pressure was found. Adjusted odds ratio (OR) was 2.0 (95% Cl, 1.1 to 3.9; p = 0.03) in the whole group and 2.5 (95% CL 1.2 to 5.1; p = 0.01) in the group truncated on the basis of age (less than or equal to 50 years). Our findings support the hypothesis that ACE is a gender-specific candidate gene for hypertension.", journal = "Scandinavian Journal of Clinical and Laboratory Investigation", title = "Angiotensin I-converting enzyme gene polymorphism in a Serbian population: a gender-specific association with hypertension", volume = "62", number = "6", pages = "469-475", doi = "10.1080/00365510260390028" }
Stanković, A., Živković, M.,& Alavantić, D.. (2002). Angiotensin I-converting enzyme gene polymorphism in a Serbian population: a gender-specific association with hypertension. in Scandinavian Journal of Clinical and Laboratory Investigation, 62(6), 469-475. https://doi.org/10.1080/00365510260390028
Stanković A, Živković M, Alavantić D. Angiotensin I-converting enzyme gene polymorphism in a Serbian population: a gender-specific association with hypertension. in Scandinavian Journal of Clinical and Laboratory Investigation. 2002;62(6):469-475. doi:10.1080/00365510260390028 .
Stanković, Aleksandra, Živković, Maja, Alavantić, Dragan, "Angiotensin I-converting enzyme gene polymorphism in a Serbian population: a gender-specific association with hypertension" in Scandinavian Journal of Clinical and Laboratory Investigation, 62, no. 6 (2002):469-475, https://doi.org/10.1080/00365510260390028 . .