Comparison of some physicochemical and pharmacokinetical parameters of Tc-99m-PAH, Tc-99m-MAG(3) and I-131-OIH
Апстракт
The purpose of this study was to compare some physicochemical characteristics as well as pharmacokinetic behavior of Tc-99m-PAH as a novel renal agent, with Tc-99m-MAG(3) and (OIH)-O-131. Tc-99m-PAH was prepared from lyophilized kit by adding (TcO4-)-Tc-99m. Labeled complex was stabile and high radiochemical purity radiopharmaceutical, with a low percentage of protein bound to human albumin and hydrophilic character. In spite of its smaller renal uptake, Tc-99m-PAH gave satisfactory renal images. Tc-99m-PAH showed faster urinary elimination than Tc-99m-MAG(3) and similar to those one for I-131-OIH. The comparison of pharmacokinetic parameters of Tc-99m-PAH, Tc-99m-MAG(3) and I-131-OIH indicated the favorable characteristics of Tc-99m-PAH.
Извор:
Journal of Radioanalytical and Nuclear Chemistry, 2002, 251, 3, 463-466
DOI: 10.1023/A:1014894527982
ISSN: 0236-5731
WoS: 000174851200021
Scopus: 2-s2.0-0036209682
Колекције
Институција/група
VinčaTY - JOUR AU - Janković, Drina AU - Đokić, Divna Đ. AU - Maksin, Tatjana N. AU - Orlić, Milan P. PY - 2002 UR - https://vinar.vin.bg.ac.rs/handle/123456789/2508 AB - The purpose of this study was to compare some physicochemical characteristics as well as pharmacokinetic behavior of Tc-99m-PAH as a novel renal agent, with Tc-99m-MAG(3) and (OIH)-O-131. Tc-99m-PAH was prepared from lyophilized kit by adding (TcO4-)-Tc-99m. Labeled complex was stabile and high radiochemical purity radiopharmaceutical, with a low percentage of protein bound to human albumin and hydrophilic character. In spite of its smaller renal uptake, Tc-99m-PAH gave satisfactory renal images. Tc-99m-PAH showed faster urinary elimination than Tc-99m-MAG(3) and similar to those one for I-131-OIH. The comparison of pharmacokinetic parameters of Tc-99m-PAH, Tc-99m-MAG(3) and I-131-OIH indicated the favorable characteristics of Tc-99m-PAH. T2 - Journal of Radioanalytical and Nuclear Chemistry T1 - Comparison of some physicochemical and pharmacokinetical parameters of Tc-99m-PAH, Tc-99m-MAG(3) and I-131-OIH VL - 251 IS - 3 SP - 463 EP - 466 DO - 10.1023/A:1014894527982 ER -
@article{ author = "Janković, Drina and Đokić, Divna Đ. and Maksin, Tatjana N. and Orlić, Milan P.", year = "2002", abstract = "The purpose of this study was to compare some physicochemical characteristics as well as pharmacokinetic behavior of Tc-99m-PAH as a novel renal agent, with Tc-99m-MAG(3) and (OIH)-O-131. Tc-99m-PAH was prepared from lyophilized kit by adding (TcO4-)-Tc-99m. Labeled complex was stabile and high radiochemical purity radiopharmaceutical, with a low percentage of protein bound to human albumin and hydrophilic character. In spite of its smaller renal uptake, Tc-99m-PAH gave satisfactory renal images. Tc-99m-PAH showed faster urinary elimination than Tc-99m-MAG(3) and similar to those one for I-131-OIH. The comparison of pharmacokinetic parameters of Tc-99m-PAH, Tc-99m-MAG(3) and I-131-OIH indicated the favorable characteristics of Tc-99m-PAH.", journal = "Journal of Radioanalytical and Nuclear Chemistry", title = "Comparison of some physicochemical and pharmacokinetical parameters of Tc-99m-PAH, Tc-99m-MAG(3) and I-131-OIH", volume = "251", number = "3", pages = "463-466", doi = "10.1023/A:1014894527982" }
Janković, D., Đokić, D. Đ., Maksin, T. N.,& Orlić, M. P.. (2002). Comparison of some physicochemical and pharmacokinetical parameters of Tc-99m-PAH, Tc-99m-MAG(3) and I-131-OIH. in Journal of Radioanalytical and Nuclear Chemistry, 251(3), 463-466. https://doi.org/10.1023/A:1014894527982
Janković D, Đokić DĐ, Maksin TN, Orlić MP. Comparison of some physicochemical and pharmacokinetical parameters of Tc-99m-PAH, Tc-99m-MAG(3) and I-131-OIH. in Journal of Radioanalytical and Nuclear Chemistry. 2002;251(3):463-466. doi:10.1023/A:1014894527982 .
Janković, Drina, Đokić, Divna Đ., Maksin, Tatjana N., Orlić, Milan P., "Comparison of some physicochemical and pharmacokinetical parameters of Tc-99m-PAH, Tc-99m-MAG(3) and I-131-OIH" in Journal of Radioanalytical and Nuclear Chemistry, 251, no. 3 (2002):463-466, https://doi.org/10.1023/A:1014894527982 . .