Association of apoE polymorphism with serum lipids in Serbian healthy population
Apstrakt
Apolipoprotein E (apoE) genotypes were determined in a subset of 591 subjects by restriction isotyping/MADGE analysis. The characterization of different apoE isoforms (133 subjects) has also been carried out by isoelectric focussing/immunoblotting of plasma. In men, levels of both total and low-density lipoprotein cholesterol among the three apoE genotype groups (E2, E3, E4) differed significantly (p LT 0.05). The E2 allele was associated with the lower both total and low-density lipoprotein cholesterol, where the E4 allele had the opposite effects. In women, no significant effect of apoE polymorphism on serum lipid levels was observed. These data could be taken into consideration in the future evaluation of the risk of cardiovascular and/or neurodegenerative diseases in Serbian population.
Ključne reči:
apo E / restriction isotyping / lipids / genetic epidemiology / Serbian populationIzvor:
Jugoslovenska Medicinska Biohemija, 2000, 19, 2, 115-120Kolekcije
Institucija/grupa
VinčaTY - JOUR AU - Stanković, Sanja AU - Spasojević-Kalimanovska, Vesna AU - Alavantić, Dragan PY - 2000 UR - https://vinar.vin.bg.ac.rs/handle/123456789/2356 AB - Apolipoprotein E (apoE) genotypes were determined in a subset of 591 subjects by restriction isotyping/MADGE analysis. The characterization of different apoE isoforms (133 subjects) has also been carried out by isoelectric focussing/immunoblotting of plasma. In men, levels of both total and low-density lipoprotein cholesterol among the three apoE genotype groups (E2, E3, E4) differed significantly (p LT 0.05). The E2 allele was associated with the lower both total and low-density lipoprotein cholesterol, where the E4 allele had the opposite effects. In women, no significant effect of apoE polymorphism on serum lipid levels was observed. These data could be taken into consideration in the future evaluation of the risk of cardiovascular and/or neurodegenerative diseases in Serbian population. T2 - Jugoslovenska Medicinska Biohemija T1 - Association of apoE polymorphism with serum lipids in Serbian healthy population VL - 19 IS - 2 SP - 115 EP - 120 UR - https://hdl.handle.net/21.15107/rcub_vinar_2356 ER -
@article{ author = "Stanković, Sanja and Spasojević-Kalimanovska, Vesna and Alavantić, Dragan", year = "2000", abstract = "Apolipoprotein E (apoE) genotypes were determined in a subset of 591 subjects by restriction isotyping/MADGE analysis. The characterization of different apoE isoforms (133 subjects) has also been carried out by isoelectric focussing/immunoblotting of plasma. In men, levels of both total and low-density lipoprotein cholesterol among the three apoE genotype groups (E2, E3, E4) differed significantly (p LT 0.05). The E2 allele was associated with the lower both total and low-density lipoprotein cholesterol, where the E4 allele had the opposite effects. In women, no significant effect of apoE polymorphism on serum lipid levels was observed. These data could be taken into consideration in the future evaluation of the risk of cardiovascular and/or neurodegenerative diseases in Serbian population.", journal = "Jugoslovenska Medicinska Biohemija", title = "Association of apoE polymorphism with serum lipids in Serbian healthy population", volume = "19", number = "2", pages = "115-120", url = "https://hdl.handle.net/21.15107/rcub_vinar_2356" }
Stanković, S., Spasojević-Kalimanovska, V.,& Alavantić, D.. (2000). Association of apoE polymorphism with serum lipids in Serbian healthy population. in Jugoslovenska Medicinska Biohemija, 19(2), 115-120. https://hdl.handle.net/21.15107/rcub_vinar_2356
Stanković S, Spasojević-Kalimanovska V, Alavantić D. Association of apoE polymorphism with serum lipids in Serbian healthy population. in Jugoslovenska Medicinska Biohemija. 2000;19(2):115-120. https://hdl.handle.net/21.15107/rcub_vinar_2356 .
Stanković, Sanja, Spasojević-Kalimanovska, Vesna, Alavantić, Dragan, "Association of apoE polymorphism with serum lipids in Serbian healthy population" in Jugoslovenska Medicinska Biohemija, 19, no. 2 (2000):115-120, https://hdl.handle.net/21.15107/rcub_vinar_2356 .