Tc-99(m)-p-aminohippuric acid as a new renal agent
Апстракт
Tc-99(m)-p-aminohippuric acid (Tc-99(m)-PAH) is a new renal radiopharmaceutical prepared from a lyophilized kit by the addition of sodium pertechnetate ((NaTcO4)-Tc-99-O-m. Each vial contains PAH, the calcium trisodium salt of diethylenetriamine pentaacetic acid (CaNa(3)DTPA) and stannous chloride (SnCl2. 2H(2)O) in an inert atmosphere. It is a stable radiopharmaceutical with high radiochemical purity ( GT 95%). Its protein binding is very similar to that of I-131-OIH, but it is hydrophilic in character. Animal studies using Tc-99(m)-PAH have indicated that it provides renal images of satisfactory quality with no external background. Despite its almost identical radiochemical purity and HPLC analysis results to Tc-99(m)-DTPA, Tc-99(m)-PAH is rapidly secreted by the kidneys in a manner consistent with tubular secretion, as confirmed by rat probenecid studies, whereas Tc-99(m)-DTPA is excreted by glomerular filtration. The pharmacokinetic parameters of Tc-99(m)-PAH (t(1/2(alpha))) = 2.5 ...min, t(1/2(beta)) = 41.7 min, Cl = 5.22 ml . min(-1), K-el 5.1 x 10(-4) min(-1)) differ from those of Tc-99(m)-DTPA. Evaluation of Tc-99(m)-PAH in two human volunteers confirmed its good renal characteristics: rapid disappearance from the vascular system, high uptake in kidneys followed by its very fast elimination, and low residual activity 20 min after its intravenous administration. (C) 1999 Lippincott Williams and Wilkins).
Извор:
Nuclear Medicine Communications, 1999, 20, 12, 1133-1140
DOI: 10.1097/00006231-199912000-00005
ISSN: 0143-3636
PubMed: 10664994
WoS: 000084668000005
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Институција/група
VinčaTY - JOUR AU - Đokić, Divna Đ. AU - Janković, Drina AU - Maksin, Tatjana N. AU - Jaksic, E AU - Beatovic, S AU - Han, R PY - 1999 UR - https://vinar.vin.bg.ac.rs/handle/123456789/2311 AB - Tc-99(m)-p-aminohippuric acid (Tc-99(m)-PAH) is a new renal radiopharmaceutical prepared from a lyophilized kit by the addition of sodium pertechnetate ((NaTcO4)-Tc-99-O-m. Each vial contains PAH, the calcium trisodium salt of diethylenetriamine pentaacetic acid (CaNa(3)DTPA) and stannous chloride (SnCl2. 2H(2)O) in an inert atmosphere. It is a stable radiopharmaceutical with high radiochemical purity ( GT 95%). Its protein binding is very similar to that of I-131-OIH, but it is hydrophilic in character. Animal studies using Tc-99(m)-PAH have indicated that it provides renal images of satisfactory quality with no external background. Despite its almost identical radiochemical purity and HPLC analysis results to Tc-99(m)-DTPA, Tc-99(m)-PAH is rapidly secreted by the kidneys in a manner consistent with tubular secretion, as confirmed by rat probenecid studies, whereas Tc-99(m)-DTPA is excreted by glomerular filtration. The pharmacokinetic parameters of Tc-99(m)-PAH (t(1/2(alpha))) = 2.5 min, t(1/2(beta)) = 41.7 min, Cl = 5.22 ml . min(-1), K-el 5.1 x 10(-4) min(-1)) differ from those of Tc-99(m)-DTPA. Evaluation of Tc-99(m)-PAH in two human volunteers confirmed its good renal characteristics: rapid disappearance from the vascular system, high uptake in kidneys followed by its very fast elimination, and low residual activity 20 min after its intravenous administration. (C) 1999 Lippincott Williams and Wilkins). T2 - Nuclear Medicine Communications T1 - Tc-99(m)-p-aminohippuric acid as a new renal agent VL - 20 IS - 12 SP - 1133 EP - 1140 DO - 10.1097/00006231-199912000-00005 ER -
@article{ author = "Đokić, Divna Đ. and Janković, Drina and Maksin, Tatjana N. and Jaksic, E and Beatovic, S and Han, R", year = "1999", abstract = "Tc-99(m)-p-aminohippuric acid (Tc-99(m)-PAH) is a new renal radiopharmaceutical prepared from a lyophilized kit by the addition of sodium pertechnetate ((NaTcO4)-Tc-99-O-m. Each vial contains PAH, the calcium trisodium salt of diethylenetriamine pentaacetic acid (CaNa(3)DTPA) and stannous chloride (SnCl2. 2H(2)O) in an inert atmosphere. It is a stable radiopharmaceutical with high radiochemical purity ( GT 95%). Its protein binding is very similar to that of I-131-OIH, but it is hydrophilic in character. Animal studies using Tc-99(m)-PAH have indicated that it provides renal images of satisfactory quality with no external background. Despite its almost identical radiochemical purity and HPLC analysis results to Tc-99(m)-DTPA, Tc-99(m)-PAH is rapidly secreted by the kidneys in a manner consistent with tubular secretion, as confirmed by rat probenecid studies, whereas Tc-99(m)-DTPA is excreted by glomerular filtration. The pharmacokinetic parameters of Tc-99(m)-PAH (t(1/2(alpha))) = 2.5 min, t(1/2(beta)) = 41.7 min, Cl = 5.22 ml . min(-1), K-el 5.1 x 10(-4) min(-1)) differ from those of Tc-99(m)-DTPA. Evaluation of Tc-99(m)-PAH in two human volunteers confirmed its good renal characteristics: rapid disappearance from the vascular system, high uptake in kidneys followed by its very fast elimination, and low residual activity 20 min after its intravenous administration. (C) 1999 Lippincott Williams and Wilkins).", journal = "Nuclear Medicine Communications", title = "Tc-99(m)-p-aminohippuric acid as a new renal agent", volume = "20", number = "12", pages = "1133-1140", doi = "10.1097/00006231-199912000-00005" }
Đokić, D. Đ., Janković, D., Maksin, T. N., Jaksic, E., Beatovic, S.,& Han, R.. (1999). Tc-99(m)-p-aminohippuric acid as a new renal agent. in Nuclear Medicine Communications, 20(12), 1133-1140. https://doi.org/10.1097/00006231-199912000-00005
Đokić DĐ, Janković D, Maksin TN, Jaksic E, Beatovic S, Han R. Tc-99(m)-p-aminohippuric acid as a new renal agent. in Nuclear Medicine Communications. 1999;20(12):1133-1140. doi:10.1097/00006231-199912000-00005 .
Đokić, Divna Đ., Janković, Drina, Maksin, Tatjana N., Jaksic, E, Beatovic, S, Han, R, "Tc-99(m)-p-aminohippuric acid as a new renal agent" in Nuclear Medicine Communications, 20, no. 12 (1999):1133-1140, https://doi.org/10.1097/00006231-199912000-00005 . .