Gas chromatography mass spectrometry determination of isosorbide 5-mononitrate and related impurities in raw materials and dosage formulations
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1997
Authors
Marinković, Valentina D.Milojković, Smiljana S.
Nedeljković, Jovan
Čomor, Jožef J.
Agbaba, Danica
Živanov-Stakić, Dobrila
Article (Published version)
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Show full item recordAbstract
A straightforward quantitative method for gas chromatography-mass spectrometry determination of isosorbide 5-mononitrate (ISSMN) and its related impurities such as isosorbide (IS), isosorbide diacetate (ISDA) and isosorbide 2-acetate-5-nitrate (IS2A5N) in raw materials as well as in dosage formulations is developed. The recovery of these materials was found to be 100.4 +/- 2.4, 99.3 +/- 4.7, 97.8 +/- 5.2 and 100.1 +/- 3.1%, while the detection limits were 27.2, 1.26, 1.02 and 0.78 mu g in dosage formulations for ISSMN, ISDA, IS2A5N, and IS, respectively. The applicability of the method was tested by analysing three different formulations of ISSMN. (C) 1997 Elsevier Science B.V.
Keywords:
isosorbide / isosorbide 5-mononitrate / isosorbide diacetate / isosorbide-2-acetate-5-nitrate / gas chromatography mass spectrometry / quality controlSource:
Journal of Pharmaceutical and Biomedical Analysis, 1997, 16, 3, 425-429Funding / projects:
- Ministry of Science and Technology of the Republic of Serbia
DOI: 10.1016/S0731-7085(97)00079-4
ISSN: 0731-7085
PubMed: 9589400
WoS: A1997YJ69500007
Scopus: 2-s2.0-0030732906
Institution/Community
VinčaTY - JOUR AU - Marinković, Valentina D. AU - Milojković, Smiljana S. AU - Nedeljković, Jovan AU - Čomor, Jožef J. AU - Agbaba, Danica AU - Živanov-Stakić, Dobrila PY - 1997 UR - https://vinar.vin.bg.ac.rs/handle/123456789/2099 AB - A straightforward quantitative method for gas chromatography-mass spectrometry determination of isosorbide 5-mononitrate (ISSMN) and its related impurities such as isosorbide (IS), isosorbide diacetate (ISDA) and isosorbide 2-acetate-5-nitrate (IS2A5N) in raw materials as well as in dosage formulations is developed. The recovery of these materials was found to be 100.4 +/- 2.4, 99.3 +/- 4.7, 97.8 +/- 5.2 and 100.1 +/- 3.1%, while the detection limits were 27.2, 1.26, 1.02 and 0.78 mu g in dosage formulations for ISSMN, ISDA, IS2A5N, and IS, respectively. The applicability of the method was tested by analysing three different formulations of ISSMN. (C) 1997 Elsevier Science B.V. T2 - Journal of Pharmaceutical and Biomedical Analysis T1 - Gas chromatography mass spectrometry determination of isosorbide 5-mononitrate and related impurities in raw materials and dosage formulations VL - 16 IS - 3 SP - 425 EP - 429 DO - 10.1016/S0731-7085(97)00079-4 ER -
@article{ author = "Marinković, Valentina D. and Milojković, Smiljana S. and Nedeljković, Jovan and Čomor, Jožef J. and Agbaba, Danica and Živanov-Stakić, Dobrila", year = "1997", abstract = "A straightforward quantitative method for gas chromatography-mass spectrometry determination of isosorbide 5-mononitrate (ISSMN) and its related impurities such as isosorbide (IS), isosorbide diacetate (ISDA) and isosorbide 2-acetate-5-nitrate (IS2A5N) in raw materials as well as in dosage formulations is developed. The recovery of these materials was found to be 100.4 +/- 2.4, 99.3 +/- 4.7, 97.8 +/- 5.2 and 100.1 +/- 3.1%, while the detection limits were 27.2, 1.26, 1.02 and 0.78 mu g in dosage formulations for ISSMN, ISDA, IS2A5N, and IS, respectively. The applicability of the method was tested by analysing three different formulations of ISSMN. (C) 1997 Elsevier Science B.V.", journal = "Journal of Pharmaceutical and Biomedical Analysis", title = "Gas chromatography mass spectrometry determination of isosorbide 5-mononitrate and related impurities in raw materials and dosage formulations", volume = "16", number = "3", pages = "425-429", doi = "10.1016/S0731-7085(97)00079-4" }
Marinković, V. D., Milojković, S. S., Nedeljković, J., Čomor, J. J., Agbaba, D.,& Živanov-Stakić, D.. (1997). Gas chromatography mass spectrometry determination of isosorbide 5-mononitrate and related impurities in raw materials and dosage formulations. in Journal of Pharmaceutical and Biomedical Analysis, 16(3), 425-429. https://doi.org/10.1016/S0731-7085(97)00079-4
Marinković VD, Milojković SS, Nedeljković J, Čomor JJ, Agbaba D, Živanov-Stakić D. Gas chromatography mass spectrometry determination of isosorbide 5-mononitrate and related impurities in raw materials and dosage formulations. in Journal of Pharmaceutical and Biomedical Analysis. 1997;16(3):425-429. doi:10.1016/S0731-7085(97)00079-4 .
Marinković, Valentina D., Milojković, Smiljana S., Nedeljković, Jovan, Čomor, Jožef J., Agbaba, Danica, Živanov-Stakić, Dobrila, "Gas chromatography mass spectrometry determination of isosorbide 5-mononitrate and related impurities in raw materials and dosage formulations" in Journal of Pharmaceutical and Biomedical Analysis, 16, no. 3 (1997):425-429, https://doi.org/10.1016/S0731-7085(97)00079-4 . .