Shelf-life of Tc-99m(Sn)-pyrophosphate
Abstract
The effect of the preparation conditions on the in vitro stability of Tc-99m(Sn)-pyrophosphate kit solution has been examined. To extend the shelf-life of the preparation, different methods of protection were tested. Nitrogen purging stabilizes the kit for at least 6 h after labeling when the content of (99)mTc-pertechnetate raises to about 5%. However, this method is ineffective in the presence of hydrogen peroxide. The protecting ability of two chemicals was also determined. Gentisic acid gave good results. In the presence of 50 mu g of gentisic acid per mi of the kit the content of pertechnetate was 1-2% throughout the examined time interval. To eliminate the influence of hydrogen peroxide (6 mu g per ml of the kit) about 100 mu g of gentisic acid is needed. N,N-diphenyl-p-phenylenediamine (DPPD) performs some protecting effect only when used in the samples protected by nitrogen purging. However its protecting ability is lower that in the case of gentisic acid.
Source:
Journal of Radioanalytical and Nuclear Chemistry - Letters, 1996, 214, 1, 29-39
DOI: 10.1007/BF02165056
ISSN: 0236-5731
WoS: A1996XQ09500004
Scopus: 2-s2.0-0029848778
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VinčaTY - JOUR AU - Vučina, Jurij L. PY - 1996 UR - https://vinar.vin.bg.ac.rs/handle/123456789/2044 AB - The effect of the preparation conditions on the in vitro stability of Tc-99m(Sn)-pyrophosphate kit solution has been examined. To extend the shelf-life of the preparation, different methods of protection were tested. Nitrogen purging stabilizes the kit for at least 6 h after labeling when the content of (99)mTc-pertechnetate raises to about 5%. However, this method is ineffective in the presence of hydrogen peroxide. The protecting ability of two chemicals was also determined. Gentisic acid gave good results. In the presence of 50 mu g of gentisic acid per mi of the kit the content of pertechnetate was 1-2% throughout the examined time interval. To eliminate the influence of hydrogen peroxide (6 mu g per ml of the kit) about 100 mu g of gentisic acid is needed. N,N-diphenyl-p-phenylenediamine (DPPD) performs some protecting effect only when used in the samples protected by nitrogen purging. However its protecting ability is lower that in the case of gentisic acid. T2 - Journal of Radioanalytical and Nuclear Chemistry - Letters T1 - Shelf-life of Tc-99m(Sn)-pyrophosphate VL - 214 IS - 1 SP - 29 EP - 39 DO - 10.1007/BF02165056 ER -
@article{ author = "Vučina, Jurij L.", year = "1996", abstract = "The effect of the preparation conditions on the in vitro stability of Tc-99m(Sn)-pyrophosphate kit solution has been examined. To extend the shelf-life of the preparation, different methods of protection were tested. Nitrogen purging stabilizes the kit for at least 6 h after labeling when the content of (99)mTc-pertechnetate raises to about 5%. However, this method is ineffective in the presence of hydrogen peroxide. The protecting ability of two chemicals was also determined. Gentisic acid gave good results. In the presence of 50 mu g of gentisic acid per mi of the kit the content of pertechnetate was 1-2% throughout the examined time interval. To eliminate the influence of hydrogen peroxide (6 mu g per ml of the kit) about 100 mu g of gentisic acid is needed. N,N-diphenyl-p-phenylenediamine (DPPD) performs some protecting effect only when used in the samples protected by nitrogen purging. However its protecting ability is lower that in the case of gentisic acid.", journal = "Journal of Radioanalytical and Nuclear Chemistry - Letters", title = "Shelf-life of Tc-99m(Sn)-pyrophosphate", volume = "214", number = "1", pages = "29-39", doi = "10.1007/BF02165056" }
Vučina, J. L.. (1996). Shelf-life of Tc-99m(Sn)-pyrophosphate. in Journal of Radioanalytical and Nuclear Chemistry - Letters, 214(1), 29-39. https://doi.org/10.1007/BF02165056
Vučina JL. Shelf-life of Tc-99m(Sn)-pyrophosphate. in Journal of Radioanalytical and Nuclear Chemistry - Letters. 1996;214(1):29-39. doi:10.1007/BF02165056 .
Vučina, Jurij L., "Shelf-life of Tc-99m(Sn)-pyrophosphate" in Journal of Radioanalytical and Nuclear Chemistry - Letters, 214, no. 1 (1996):29-39, https://doi.org/10.1007/BF02165056 . .