Use of rodent data for cancer risk assessment of smokeless tobacco in the regulatory context
Само за регистроване кориснике
2017
Информативни прилог (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
To support risk management decisions, information from different fields has been integrated in this presentation to provide a realistic quantitative cancer risk assessment of smokeless tobacco. Smoking among Swedish men is currently below 10%, while about 20% use a special smokeless tobacco (snus) as a substitute for cigarettes. Epidemiological data and molecular biomarkers demonstrate that rodent bioassays with tobacco specific nitrosamines (TSNA) overestimate cancer risk from snus by more than one order of magnitude. The underlying reasons are discussed. DNA damage constitutes a necessary, although not sufficient prerequisite for cancer initiation. Individuals who have not used tobacco exhibit DNA lesions identical with those induced by TSNA. No increase above this adduct background can be shown from snus, and extensive epidemiological studies in Sweden have failed to demonstrate elevated cancer risks even in long term users. A bench mark for acceptable risk of 1/10(6) derived from r...odent data has been suggested when regulating snus. By relating similarly derived estimates for some food contaminants, the implementation even of a limit of 1/10(4) may be unrealistic. The management of smokeless tobacco products has rarely been based on a scientifically sound risk assessment, where attention is given to the outstandingly higher hazards associated with smoking. (C) 2017 Elsevier Inc. All rights reserved.
Кључне речи:
Smokeless tobacco / Snus / Cancer / Epidemiology / TSNA / DNA adducts / Hemoglobin adducts / Risk assessment / Bioassay / RegulationИзвор:
Regulatory Toxicology and Pharmacology, 2017, 88, 338-348Финансирање / пројекти:
- Swedish Match AB
DOI: 10.1016/j.yrtph.2017.06.005
ISSN: 0273-2300; 1096-0295
PubMed: 28625913
WoS: 000407872900035
Scopus: 2-s2.0-85021185815
Колекције
Институција/група
VinčaTY - JOUR AU - Nilsson, Robert PY - 2017 UR - https://vinar.vin.bg.ac.rs/handle/123456789/1687 AB - To support risk management decisions, information from different fields has been integrated in this presentation to provide a realistic quantitative cancer risk assessment of smokeless tobacco. Smoking among Swedish men is currently below 10%, while about 20% use a special smokeless tobacco (snus) as a substitute for cigarettes. Epidemiological data and molecular biomarkers demonstrate that rodent bioassays with tobacco specific nitrosamines (TSNA) overestimate cancer risk from snus by more than one order of magnitude. The underlying reasons are discussed. DNA damage constitutes a necessary, although not sufficient prerequisite for cancer initiation. Individuals who have not used tobacco exhibit DNA lesions identical with those induced by TSNA. No increase above this adduct background can be shown from snus, and extensive epidemiological studies in Sweden have failed to demonstrate elevated cancer risks even in long term users. A bench mark for acceptable risk of 1/10(6) derived from rodent data has been suggested when regulating snus. By relating similarly derived estimates for some food contaminants, the implementation even of a limit of 1/10(4) may be unrealistic. The management of smokeless tobacco products has rarely been based on a scientifically sound risk assessment, where attention is given to the outstandingly higher hazards associated with smoking. (C) 2017 Elsevier Inc. All rights reserved. T2 - Regulatory Toxicology and Pharmacology T1 - Use of rodent data for cancer risk assessment of smokeless tobacco in the regulatory context VL - 88 SP - 338 EP - 348 DO - 10.1016/j.yrtph.2017.06.005 ER -
@article{ author = "Nilsson, Robert", year = "2017", abstract = "To support risk management decisions, information from different fields has been integrated in this presentation to provide a realistic quantitative cancer risk assessment of smokeless tobacco. Smoking among Swedish men is currently below 10%, while about 20% use a special smokeless tobacco (snus) as a substitute for cigarettes. Epidemiological data and molecular biomarkers demonstrate that rodent bioassays with tobacco specific nitrosamines (TSNA) overestimate cancer risk from snus by more than one order of magnitude. The underlying reasons are discussed. DNA damage constitutes a necessary, although not sufficient prerequisite for cancer initiation. Individuals who have not used tobacco exhibit DNA lesions identical with those induced by TSNA. No increase above this adduct background can be shown from snus, and extensive epidemiological studies in Sweden have failed to demonstrate elevated cancer risks even in long term users. A bench mark for acceptable risk of 1/10(6) derived from rodent data has been suggested when regulating snus. By relating similarly derived estimates for some food contaminants, the implementation even of a limit of 1/10(4) may be unrealistic. The management of smokeless tobacco products has rarely been based on a scientifically sound risk assessment, where attention is given to the outstandingly higher hazards associated with smoking. (C) 2017 Elsevier Inc. All rights reserved.", journal = "Regulatory Toxicology and Pharmacology", title = "Use of rodent data for cancer risk assessment of smokeless tobacco in the regulatory context", volume = "88", pages = "338-348", doi = "10.1016/j.yrtph.2017.06.005" }
Nilsson, R.. (2017). Use of rodent data for cancer risk assessment of smokeless tobacco in the regulatory context. in Regulatory Toxicology and Pharmacology, 88, 338-348. https://doi.org/10.1016/j.yrtph.2017.06.005
Nilsson R. Use of rodent data for cancer risk assessment of smokeless tobacco in the regulatory context. in Regulatory Toxicology and Pharmacology. 2017;88:338-348. doi:10.1016/j.yrtph.2017.06.005 .
Nilsson, Robert, "Use of rodent data for cancer risk assessment of smokeless tobacco in the regulatory context" in Regulatory Toxicology and Pharmacology, 88 (2017):338-348, https://doi.org/10.1016/j.yrtph.2017.06.005 . .