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Case with triple-negative breast cancer shows overexpression of both cFOS and TGF-beta 1 in node-positive tissue
dc.creator | Ivanović, Vesna | |
dc.creator | Dedović-Tanić, Nasta | |
dc.creator | Milovanović, Zorka M. | |
dc.creator | Lukić, Silvana | |
dc.creator | Nikolić, Srđan | |
dc.creator | Baltić, Vladimir | |
dc.creator | Stojiljković, Bratislav | |
dc.creator | Demajo, Miroslav | |
dc.creator | Mandušić, Vesna | |
dc.creator | Dimitrijević, Bogomir B. | |
dc.date.accessioned | 2018-03-01T17:15:55Z | |
dc.date.available | 2018-03-01T17:15:55Z | |
dc.date.issued | 2016 | |
dc.identifier.issn | 1741-0541 | |
dc.identifier.issn | 1744-828X | |
dc.identifier.uri | https://vinar.vin.bg.ac.rs/handle/123456789/1327 | |
dc.description.abstract | We present herein a case report style article on a rare advanced triple-negative breast cancer (TNBC) patient with 6-month disease-free interval, and 10-month overall survival. Our results demonstrate that the poor clinical outcome of this patient was associated with pronounced, more than fivefold higher, overexpression of both cFOS and TGF-beta 1 proteins in its metastatic nodal tissue extracts, when compared with the values of the two non-TNBC controls (with zero disease-free interval and overall survival). This original observation suggests, for the first time, that both the cFOS and TGF-beta 1 may be considered as a pair of biomarkers for an early assessment of poor prognosis for TNBC patients. The possible clinical implication of this observation is discussed. | en |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173049/RS// | |
dc.rights | restrictedAccess | en |
dc.source | Personalized Medicine | en |
dc.subject | cFOS | en |
dc.subject | metastatic axillary lymph nodes | en |
dc.subject | TGF-beta 1 | en |
dc.subject | triple-negative breast cancer | en |
dc.title | Case with triple-negative breast cancer shows overexpression of both cFOS and TGF-beta 1 in node-positive tissue | en |
dc.type | article | en |
dcterms.abstract | Николиц, Срдјан; Мандушић Весна; Миловановиц, Зорка; Димитријевић Богомир Б.; Лукиц, Силвана; Ивановиц, Весна; Стојиљковиц, Братислав; Балтиц, Владимир; Дедовиц-Таниц, Наста; Демајо, Мирослав; | |
dc.citation.volume | 13 | |
dc.citation.issue | 6 | |
dc.citation.spage | 523 | |
dc.citation.epage | 530 | |
dc.identifier.wos | 000389179500001 | |
dc.identifier.doi | 10.2217/pme-2016-0032 | |
dc.citation.rank | M23 | |
dc.type.version | publishedVersion | |
dc.identifier.scopus | 2-s2.0-84994558857 |
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